Dental pulp stem cells and their potential roles in central nervous system regeneration and repair

2013 ◽  
Vol 91 (11) ◽  
pp. 1383-1393 ◽  
Author(s):  
Fraser Young ◽  
Alastair Sloan ◽  
Bing Song
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells

scholarly journals Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Stem Cells ◽  
2016 ◽  
Vol 35 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Ben Mead ◽  
Ann Logan ◽  
Martin Berry ◽  
Wendy Leadbeater ◽  
Ben A. Scheven
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Concise Review ◽  
Central Nervous System Repair

scholarly journals Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Lihua Luo ◽  
Yan He ◽  
Xiaoyan Wang ◽  
Brian Key ◽  
Bae Hoon Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Neuronal Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Neural Regeneration ◽  
Differentiation Potential ◽  
Neural Repair ◽  
Nervous Systems ◽  
Potential Applications

This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regeneration. Dental pulp stem cells (DPSCs) derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors that are suitable for neuronal and axonal regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured nerve. These unique properties together with their ready accessibility make DPSCs an attractive cell source for tissue engineering in injured and diseased nervous systems. In this review, we interrogate the neuronal differentiation potential as well as the neuroprotective, neurotrophic, angiogenic, and immunomodulatory properties of DPSCs and its application in the injured nervous system. Taken together, DPSCs are an ideal stem cell resource for therapeutic approaches to neural repair and regeneration in nerve diseases.

scholarly journals Dental pulp stem cells as a therapy for congenital entero-neuropathy

2021 ◽  
Author(s):  
Koichiro Yoshimaru ◽  
Takayoshi Yamaza ◽  
Shunichi Kajioka ◽  
Soichiro Sonoda ◽  
Yusuke Yanagi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Neural Crest ◽  
Enteric Nervous System ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Enteric Neurons ◽  
Deciduous Teeth ◽  
Pacemaker Cells ◽  
Distal Intestine

Abstract Hirschsprung’s disease is a congenital entero-neuropathy that causes chronic constipation and intestinal obstruction. New treatments for entero-neuropathy are needed because current surgical strategies have limitations5. Entero-neuropathy results from enteric nervous system dysfunction due to incomplete colonization of the distal intestine by neural crest-derived cells. Impaired cooperation between the enteric nervous system and intestinal pacemaker cells may also contribute to entero-neuropathy. Stem cell therapy to repair these multiple defects represents a novel treatment approach. Dental pulp stem cells derived from deciduous teeth (dDPSCs) are multipotent cranial neural crest-derived cells, but it remains unknown whether dDPSCs have potential as a new therapy for entero-neuropathy. Here we show that intravenous transplantation of dDPSCs into the Japanese Fancy-1 mouse, an established model of hypoganglionosis and entero-neuropathy, improves large intestinal structure and function and prolongs survival. Intravenously injected dDPSCs migrate to affected regions of the intestine through interactions between stromal cell-derived factor-1α and C-X-C chemokine receptor type-4. Transplanted dDPSCs differentiate into both pacemaker cells and enteric neurons in the proximal colon to improve electrical and peristaltic activity. Our findings indicate that transplanted dDPSCs can differentiate into different cell types to correct entero-neuropathy-associated defects.

scholarly journals Ethanol and Stem Cells

2017 ◽  
Vol 3 ◽  
pp. 58
Author(s):  
Afsaneh Farokhi ◽  
Fatemeh Koohpeima ◽  
Mohammad Javad Mokhtari
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
High Risk ◽  
Dental Pulp ◽  
Embryonic Stem ◽  
Ethanol Exposure ◽  
Tooth Decay ◽  
The Central Nervous System

Many studies have showed disadvantageous effect of ethanol exposure on stem cells. Ethanol exposure during development leads injury to various types of stem cells including neural stem cells (NSCs), dental pulp stem cells, mesenchymal stem cells, embryonic stem cells and etc. Because NSCs play a basic role in the development and maturation of the central nervous system, it is vital to understand the effect of ethanol on NSCs differentiation. Additionally, alcohol misusage appears lead to periodontal disease, tooth decay and mouth wounds that are potentially precancerous. Individuals who abuse alcohol are at high risk of having seriously destroyed teeth, gums and compromised oral health in general. Some of these adverse situations maybe are because of ethanol effects on stem cells. Therefore, here, ethanol effects on the various types of stem cells were reviewed.

Neural Stem Cells to Glial Cells an Important Factor for Brain Injury

2020 ◽  
Author(s):  
Prithiv K R Kumar
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Neural Stem Cells ◽  
Glial Cells ◽  
Brain Injuries ◽  
The Body ◽  
The Central Nervous System ◽  
Near Future

Stem cells have the capacity to differentiate into any type of cell or organ. Stems cell originate from any part of the body, including the brain. Brain cells or rather neural stem cells have the capacitive advantage of differentiating into the central nervous system leading to the formation of neurons and glial cells. Neural stem cells should have a source by editing DNA, or by mixings chemical enzymes of iPSCs. By this method, a limitless number of neuron stem cells can be obtained. Increase in supply of NSCs help in repairing glial cells which in-turn heal the central nervous system. Generally, brain injuries cause motor and sensory deficits leading to stroke. With all trials from novel therapeutic methods to enhanced rehabilitation time, the economy and quality of life is suppressed. Only PSCs have proven effective for grafting cells into NSCs. Neurons derived from stem cells is the only challenge that limits in-vitro usage in the near future.

Tranylcypromine Attenuates Senescence in Dental Pulp Stem Cells

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Junjun Liu ◽  
Zhi Liu ◽  
Chunyan Wang ◽  
Fang Yu ◽  
Wenping Cai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells
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