scholarly journals Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair

Stem Cells ◽  
2016 ◽  
Vol 35 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Ben Mead ◽  
Ann Logan ◽  
Martin Berry ◽  
Wendy Leadbeater ◽  
Ben A. Scheven
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Therapy ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Concise Review ◽  
Central Nervous System Repair

Central nervous system repair and stem cells

2007 ◽  
Vol 1302 ◽  
pp. 154-163 ◽  
Author(s):  
Rahul Jandial ◽  
Ilyas Singec ◽  
Vincent J. Duenas ◽  
Allen L. Ho ◽  
Michael L. Levy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Repair

scholarly journals Dental Pulp Stem Cells: An Attractive Alternative for Cell Therapy in Ischemic Stroke

2019 ◽  
Vol 10 ◽  
Author(s):  
Xiaoyan Lan ◽  
Zhengwu Sun ◽  
Chengyan Chu ◽  
Johannes Boltze ◽  
Shen Li
Keyword(s):  
Stem Cells ◽  
Ischemic Stroke ◽  
Cell Therapy ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Attractive Alternative

Harnessing Endogenous Stem Cells for Central Nervous System Repair

2005 ◽  
pp. 387-xvi
Author(s):  
D. Chichung Lie ◽  
Sophia A. Colamarino ◽  
Hongjun Song ◽  
Fred H. Gage
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Repair

scholarly journals Human Immature Dental Pulp Stem Cells (hIDPSCs), Their Application to Cell Therapy and Bioengineering: An Analysis by Systematic Revision of the Last Decade of Literature

2013 ◽  
Vol 296 (12) ◽  
pp. 1923-1928 ◽  
Author(s):  
Priscilla Vianna De Souza ◽  
Fabiana Bucholdz Teixeira Alves ◽  
Cristina Lucia Sant'Ana Costa Ayub ◽  
Maria Albertina De Miranda Soares ◽  
Jose Rosa Gomes
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Systematic Revision

scholarly journals Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Lihua Luo ◽  
Yan He ◽  
Xiaoyan Wang ◽  
Brian Key ◽  
Bae Hoon Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nervous System ◽  
Neuronal Differentiation ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Neural Regeneration ◽  
Differentiation Potential ◽  
Neural Repair ◽  
Nervous Systems ◽  
Potential Applications

This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regeneration. Dental pulp stem cells (DPSCs) derive from a cranial neural crest lineage, retain a remarkable potential for neuronal differentiation, and additionally express multiple factors that are suitable for neuronal and axonal regeneration. DPSCs can also express immunomodulatory factors that stimulate formation of blood vessels and enhance regeneration and repair of injured nerve. These unique properties together with their ready accessibility make DPSCs an attractive cell source for tissue engineering in injured and diseased nervous systems. In this review, we interrogate the neuronal differentiation potential as well as the neuroprotective, neurotrophic, angiogenic, and immunomodulatory properties of DPSCs and its application in the injured nervous system. Taken together, DPSCs are an ideal stem cell resource for therapeutic approaches to neural repair and regeneration in nerve diseases.

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