Multistep Continuous-Flow Processes for the Preparation of Heterocyclic Active Pharmaceutical Ingredients

2018 ◽  
pp. 1-102
Author(s):  
Romaric Gérardy ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Flow Processes

scholarly journals Continuous one-flow multi-step synthesis of active pharmaceutical ingredients

2020 ◽  
Vol 5 (7) ◽  
pp. 1186-1197 ◽  
Author(s):  
Victor R. L. J. Bloemendal ◽  
Mathilde A. C. H. Janssen ◽  
Jan C. M. van Hest ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Flow Processes ◽  
Selection Of

This review highlights a selection of multistep continuous flow (one-flow) processes leading to the synthesis of active pharmaceutical ingredients (APIs).

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

2022 ◽  
Author(s):  
Cloudius Sagandira ◽  
Sinazo Nqeketo ◽  
Kanysile Mhlana ◽  
Thembela Sonti ◽  
Paul Watts ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Industrial Revolution ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
New Paradigm ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...

Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals

2020 ◽  
Vol 5 (9) ◽  
pp. 1527-1555 ◽  
Author(s):  
Zsolt Fülöp ◽  
Péter Szemesi ◽  
Péter Bana ◽  
János Éles ◽  
István Greiner
Keyword(s):  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Design Strategies ◽  
Flow Synthesis ◽  
Pharmaceutical Ingredients ◽  
Continuous Preparation

This review focuses on the flow-oriented design (FOD) in the multi-step continuous-flow synthesis of active pharmaceutical ingredients.

Continuous flow upgrading of glycerol toward oxiranes and active pharmaceutical ingredients thereof

2019 ◽  
Vol 21 (16) ◽  
pp. 4422-4433 ◽  
Author(s):  
Romain Morodo ◽  
Romaric Gérardy ◽  
Guillaume Petit ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Amino Alcohol ◽  
Continuous Flow ◽  
Value Added ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients

A robust continuous flow procedure for the transformation of bio-based glycerol into high value-added β-amino alcohol active pharmaceutical ingredients.

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

2019 ◽  
Vol 17 (6) ◽  
pp. 1552-1557 ◽  
Author(s):  
Renata M. Aguiar ◽  
Raquel A. C. Leão ◽  
Alejandro Mata ◽  
David Cantillo ◽  
C. Oliver Kappe ◽  
...  
Keyword(s):  
Amino Acids ◽  
Continuous Flow ◽  
Building Blocks ◽  
Active Pharmaceutical Ingredients ◽  
Enantiomerically Pure ◽  
Pharmaceutical Ingredients ◽  
Chiral Intermediates

Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs), being α-amino acids and their derivatives widely applied as building blocks.

Selectivity engineering of the diazotization reaction in a continuous flow reactor

2016 ◽  
Vol 1 (4) ◽  
pp. 387-396 ◽  
Author(s):  
C. A. Shukla ◽  
A. A. Kulkarni ◽  
V. V. Ranade
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Diazonium Salts ◽  
Fine Chemicals ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Reactor

In situ generated diazonium salts are useful intermediates for the synthesis of fine chemicals and active pharmaceutical ingredients. This paper presents a methodology for selectivity engineering of the diazotization reaction in continuous reactors.

scholarly journals Advanced Continuous-Flow Microfluidic Device for Parallel Screening of Crystal Polymorphs, Morphology and Kinetics at Controlled Supersaturation

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Paria Coliaie ◽  
Manish S Kelkar ◽  
Marianne Langston ◽  
Chengxiang Liu ◽  
Neda Nazemifard ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Continuous Flow ◽  
Active Pharmaceutical Ingredients ◽  
Combinatorial Screening ◽  
Crystalline Materials ◽  
Pharmaceutical Ingredients ◽  
Parallel Screening

A flow-controlled microfluidic device for parallel and combinatorial screening of crystalline materials can profoundly impact the discovery and development of active pharmaceutical ingredients and other crystalline materials. While the existing...

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