Antibody Response to Trivalent Influenza Vaccine in the Northern and the Southern Hemisphere in Elite Athletes

2018 ◽  
pp. 49-54
Author(s):  
Jarosław Krzywański ◽  
Aneta Nitsch-Osuch ◽  
Tomasz Mikulski ◽  
Hubert Krysztofiak ◽  
Andrzej Pokrywka ◽  
...  
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Southern Hemisphere ◽  
Elite Athletes ◽  
Trivalent Influenza Vaccine

scholarly journals Trivalent influenza vaccine-induced antibody response to circulating influenza a (H3N2) viruses in 2010/11 and 2011/12 seasons

2015 ◽  
Vol 11 (2) ◽  
pp. 386-390 ◽  
Author(s):  
Satoshi Hiroi ◽  
Saeko Morikawa ◽  
Keiko Nakata ◽  
Akiko Maeda ◽  
Tsuneji Kanno ◽  
...  
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Trivalent Influenza Vaccine

scholarly journals Immunoglobulin G, A and M response to influenza vaccination in different age groups: effects of priming and boosting

1986 ◽  
Vol 96 (3) ◽  
pp. 513-522 ◽  
Author(s):  
Walter E. P. Beyer ◽  
Jos T. M. Van Der Logt ◽  
Ruud van Beek ◽  
Nic Masurel
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Influenza A ◽  
Influenza Infection ◽  
Age Groups ◽  
Antibody Responses ◽  
Trivalent Influenza Vaccine ◽  
Antibody Capture ◽  
The Mean ◽  
Original Antigenic Sin

SUMMARYFifty volunteers, treated with an inactivated trivalent influenza vaccine containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 virus, were subdivided according to the estimated first exposure to influenza in their lifetime (priming) and the presence of antibodies against the vaccine components in the pre-vaccination sera. The isotypic antibody response (IgG, IgA, IgM) was determined by means of an antibody capture haemadsorption immunosorbent technique. For all three vaccine components, previously seropositive subjects produced antibodies of the IgG- and IgA-class more frequently than previously seronegative persons. Subjects primed to one of the influenza A subtypes showed more IgG and IgA responses in comparison with those unprimed (prime-effect). In contrast, IgM antibodies occurred in only 19 and 11% of primed, but in 59 and 54% of unprimed subjects, for A (H3N2) and A (HlNl), respectively. The incidence of IgM titre rises was not influenced by the prevaccination state. However, the mean magnitude of anti-A(H1N1)-IgM titre rises was greater in those previously seronegative. The concepts of primary and reinfection and of ‘original antigenic sin’ are discussed, and it is suggested that age and, if possible, serological state prior to antigen-exposure should be taken into account when studying isotypic antibody responses after influenza infection or vaccination.

scholarly journals Potential Antigenic Mismatch of the H3N2 Component of the 2019 Southern Hemisphere Influenza Vaccine

2019 ◽  
Vol 70 (11) ◽  
pp. 2432-2434 ◽  
Author(s):  
Sigrid Gouma ◽  
Madison Weirick ◽  
Scott E Hensley
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Southern Hemisphere ◽  
Antigenic Site

Abstract Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic as most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.

scholarly journals Role of viral RNA and lipid in the adverse events associated with the 2010 Southern Hemisphere trivalent influenza vaccine

Vaccine ◽  
2014 ◽  
Vol 32 (30) ◽  
pp. 3869-3876 ◽  
Author(s):  
Steve Rockman ◽  
Dorit Becher ◽  
Allison Dyson ◽  
Sandra Koernig ◽  
Adriana Baz Morelli ◽  
...  
Keyword(s):  
Adverse Events ◽  
Influenza Vaccine ◽  
Southern Hemisphere ◽  
Viral Rna ◽  
Trivalent Influenza Vaccine

scholarly journals Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine

2019 ◽  
Author(s):  
Sigrid Gouma ◽  
Madison Weirick ◽  
Scott E. Hensley
Keyword(s):  
Antibody Response ◽  
Influenza Vaccine ◽  
Southern Hemisphere ◽  
Antigenic Site

AbstractHere, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.

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