Characterization of cDNAs Species Encoding the Tat Protein of Caprine Arthritis Encephalitis Virus

Virology ◽  
1994 ◽  
Vol 204 (2) ◽  
pp. 828-834 ◽  
Author(s):  
Hagar Kalinski ◽  
Pnina Mashiah ◽  
Dagan Rotem ◽  
Yael Orzech ◽  
Levana Sherman ◽  
...  
Keyword(s):  
Encephalitis Virus ◽  
Tat Protein ◽  
Caprine Arthritis Encephalitis Virus

Characterization of caprine arthritis-encephalitis virus: A retrovirus of goats

1981 ◽  
Vol 67 (1) ◽  
pp. 111-117 ◽  
Author(s):  
W. P. Cheevers ◽  
S. Roberson ◽  
P. Klevjer-Anderson ◽  
T. B. Crawford
Keyword(s):  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus

Molecular characterization of the gag gene of caprine arthritis encephalitis virus from goats in the Philippines

2015 ◽  
Vol 160 (4) ◽  
pp. 969-978 ◽  
Author(s):  
Ryan Bismark C. Padiernos ◽  
Michelle M. Balbin ◽  
Arman M. Parayao ◽  
Claro N. Mingala
Keyword(s):  
Molecular Characterization ◽  
The Philippines ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus

scholarly journals Maedi-Visna Virus and Caprine Arthritis Encephalitis Virus Genomes Encode a Vpr-Like but No Tat Protein

2003 ◽  
Vol 77 (17) ◽  
pp. 9632-9638 ◽  
Author(s):  
Stéphanie Villet ◽  
Baya Amel Bouzar ◽  
Thierry Morin ◽  
Gérard Verdier ◽  
Catherine Legras ◽  
...  
Keyword(s):  
Protein Structures ◽  
Activation Function ◽  
Encephalitis Virus ◽  
Accessory Protein ◽  
Tat Protein ◽  
Caprine Arthritis Encephalitis Virus ◽  
Transfected Cells ◽  
Visna Virus ◽  
Maedi Visna Virus ◽  
Hiv 1

ABSTRACT A small open reading frame (ORF) in maedi-visna virus (MVV) and caprine arthritis encephalitis virus (CAEV) was initially named “tat” by analogy with a similarly placed ORF in the primate lentiviruses. The encoded “Tat” protein was ascribed the function of up regulation of the viral transcription from the long terminal repeat (LTR) promoter, but we have recently reported that MVV and CAEV Tat proteins lack trans-activation function activity under physiological conditions (S. Villet, C. Faure, B. Bouzar, G. Verdien, Y. Chebloune, and C. Legras, Virology 307:317-327, 2003). In the present work, we show that MVV Tat localizes to the nucleus of transfected cells, probably through the action of a nuclear localization signal in its C-terminal portion. We also show that, unlike the human immunodeficiency virus (HIV) Tat protein, MVV Tat was not secreted into the medium by transfected human or caprine cells in the absence of cell lysis but that, like the primate accessory protein Vpr, MVV and CAEV Tat proteins were incorporated into viral particles. In addition, analysis of the primary protein structures showed that small-ruminant lentivirus (SRLV) Tat proteins are more similar to the HIV type 1 (HIV-1) Vpr protein than to HIV-1 Tat. We also demonstrate a functional similarity between the SRLV Tat proteins and the HIV-1 Vpr product in the induction of a specific G2 arrest of the cell cycle in MVV Tat-transfected cells, which increases the G2/G1 ratio 2.8-fold. Together, these data strongly suggest that the tat ORF in the SRLV genomes does not code for a regulatory transactivator of the LTR but, rather, for a Vpr-like accessory protein.

scholarly journals Characterization of a new 5' splice site within the caprine arthritis encephalitis virus genome: evidence for a novel auxiliary protein

Retrovirology ◽  
2008 ◽  
Vol 5 (1) ◽  
pp. 22 ◽  
Author(s):  
Stephen Valas ◽  
Morgane Rolland ◽  
Cécile Perrin ◽  
Gérard Perrin ◽  
Robert Z Mamoun
Keyword(s):  
Splice Site ◽  
Virus Genome ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus ◽  
Auxiliary Protein
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