scholarly journals Genetic Characterization of Two Phenotypically Distinct North American Ovine Lentiviruses and Their Possible Origin from Caprine Arthritis-Encephalitis Virus

Virology ◽  
1996 ◽  
Vol 225 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Bradley M. Karr ◽  
Yahia Chebloune ◽  
Kevin Leung ◽  
Opendra Narayan
Keyword(s):  
North American ◽  
Genetic Characterization ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus

scholarly journals Host Range of Small-Ruminant Lentivirus Cytopathic Variants Determined with a Selectable Caprine Arthritis- Encephalitis Virus Pseudotype System

2001 ◽  
Vol 75 (16) ◽  
pp. 7384-7391 ◽  
Author(s):  
Isidro Hötzel ◽  
William P. Cheevers
Keyword(s):  
Host Range ◽  
Species Distribution ◽  
North American ◽  
Common Property ◽  
Small Ruminant ◽  
Human Cells ◽  
Encephalitis Virus ◽  
Envelope Glycoproteins ◽  
Pseudotyped Virus ◽  
Caprine Arthritis Encephalitis Virus

ABSTRACT The small-ruminant lentiviruses ovine maedi-visna virus (MVV) and caprine arthritis-encephalitis virus (CAEV) cause encephalitis, progressive pneumonia, arthritis, and mastitis in sheep and goats. Icelandic MVV strains, which are lytic in tissue culture, have a wide species distribution of functional receptors, which includes human cells. In contrast, functional receptors for the nonlytic CAEV CO are absent from human cells. To determine if the wide species distribution of functional receptors is a common property of MVV strains or related to cytopathic phenotype, we tested the infectivity of viruses pseudotyped with the envelope glycoproteins of MVV K1514, CAEV CO, and lytic and nonlytic North American MVV strains to cells of different species. Replication-defective CAEV proviral constructs lacking the env, tat, andvif genes and carrying the neomycin phosphotransferase gene in the vif-tat region were developed for the infectivity assays. Cotransfection of human 293T cells with these proviral constructs and plasmids expressing CAEV, MVV, or vesicular stomatitis virus envelope glycoproteins produced infectious pseudotyped virus which induced resistance of infected cells to G418. Using these pseudotypes, we confirmed the wide species distribution of Icelandic MVV receptors and the narrow host range of CAEV. However, functional receptors for the two North American MVV strains tested, unlike the Icelandic MVV and similar to CAEV, were limited to cells of ruminant species, regardless of cytopathic phenotype. The results indicate a differential receptor recognition by MVV strains which is unrelated to cytopathic phenotype.

scholarly journals Genetic Characterization of North American Populations of the Wheat Curl Mite and Dry Bulb Mite

2012 ◽  
Vol 105 (5) ◽  
pp. 1801-1808 ◽  
Author(s):  
Gary L. Hein ◽  
Roy French ◽  
Benjawan Siriwetwiwat ◽  
James W. Amrine
Keyword(s):  
North American ◽  
Genetic Characterization ◽  
Wheat Curl Mite ◽  
Bulb Mite

Characterization of caprine arthritis-encephalitis virus: A retrovirus of goats

1981 ◽  
Vol 67 (1) ◽  
pp. 111-117 ◽  
Author(s):  
W. P. Cheevers ◽  
S. Roberson ◽  
P. Klevjer-Anderson ◽  
T. B. Crawford
Keyword(s):  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus

Molecular characterization of the gag gene of caprine arthritis encephalitis virus from goats in the Philippines

2015 ◽  
Vol 160 (4) ◽  
pp. 969-978 ◽  
Author(s):  
Ryan Bismark C. Padiernos ◽  
Michelle M. Balbin ◽  
Arman M. Parayao ◽  
Claro N. Mingala
Keyword(s):  
Molecular Characterization ◽  
The Philippines ◽  
Encephalitis Virus ◽  
Caprine Arthritis Encephalitis Virus
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