Effects of Great Lakes Fish Consumption on the Immune System of Sprague–Dawley Rats Investigated during a Two-Generation Reproductive Study

1998 ◽  
Vol 27 (1) ◽  
pp. S40-S54 ◽  
Author(s):  
H. Tryphonas ◽  
M. Fournier ◽  
F. Lacroix ◽  
P. McGuire ◽  
S. Hayward ◽  
...  
Keyword(s):  
Immune System ◽  
Great Lakes ◽  
Fish Consumption ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Reproductive Study

scholarly journals Evidences Suggesting that Distinct Immunological and Cellular Responses to Light Damage Distinguishes Juvenile and Adult Rat Retinas

2019 ◽  
Vol 20 (11) ◽  
pp. 2744
Author(s):  
Anna Polosa ◽  
Shasha Lv ◽  
Wassila Ait Igrine ◽  
Laura-Alexie Chevrolat ◽  
Hyba Bessaklia ◽  
...  
Keyword(s):  
Immune System ◽  
Light Exposure ◽  
Age Related Macular Degeneration ◽  
Light Damage ◽  
Sprague Dawley ◽  
Adult Rat ◽  
Age Related ◽  
Degenerative Disorders ◽  
Sprague Dawley Rats ◽  
Dose Dependent

To unravel the mechanisms behind the higher resistance to light damage of juvenile (JR) versus adult (AR) rats, Sprague Dawley rats were exposed to a bright luminous environment of 10, 000 lux. The light-induced retinopathy (LIR) was assessed with histology, electroretinography and immunohistochemistry (IHC). In JR, 2 days of exposure induced the typical LIR, while >3 days added little LIR. IHC revealed a subtle migration of microglia (Iba1 marker) from the inner to the outer retina after 3 days of exposure in JR contrasting with the stronger reaction seen after 1 day in AR. Similarly, in JR, the Müller cells expressed less intense GFAP, CNTF and FGF2 staining compared to AR. Our results suggest that in JR the degree of retinal damage is not proportional to the duration of light exposure (i.e., dose-independent retinopathy), contrasting with the dose-dependent LIR reported in AR. The immature immune system in JR may explain the delayed and/or weaker inflammatory response compared to AR, a finding that would also point to the devastating contribution of the immune system in generating the LIR phenotype, a claim also advanced to explain the pathophysiology of other retinal degenerative disorders such as Age-related Macular Degeneration, Diabetic Retinopathy and Retinitis Pigmentosa.

scholarly journals The Influence of Pre- and Post-natal Exposure to Methoxychlor on the Immune System and Renal Function of Sprague-Dawley Rats

2005 ◽  
Vol 18 (2) ◽  
pp. 89-98
Author(s):  
Yukiko Takeuchi ◽  
Naofumi Takahashi ◽  
Tadashi Kosaka ◽  
Koichi Hayashi ◽  
Yuko Chiba ◽  
...  
Keyword(s):  
Renal Function ◽  
Immune System ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study

2000 ◽  
Vol 14 (6) ◽  
pp. 513-532 ◽  
Author(s):  
Tetsuji Nagao ◽  
Ryo Ohta ◽  
Hideki Marumo ◽  
Tomoko Shindo ◽  
Shinsuke Yoshimura ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Butyl Benzyl Phthalate ◽  
Sprague Dawley Rats ◽  
Reproductive Study

scholarly journals Effects of Fumonisin B1 on the Immune System of Sprague-Dawley Rats Following a 14-Day Oral (Gavage) Exposure

1997 ◽  
Vol 39 (1) ◽  
pp. 53-59
Author(s):  
H. Tryphonas ◽  
G. Bondy ◽  
J. D. Miller ◽  
F. Lacroix ◽  
M. Hodgen ◽  
...  
Keyword(s):  
Immune System ◽  
Fumonisin B1 ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Sprague Dawley Rats

scholarly journals Effect of different sweeteners on the oral microbiota and immune system of Sprague Dawley rats

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xi Cheng ◽  
Xiurong Guo ◽  
Feihong Huang ◽  
Hui Lei ◽  
Quan Zhou ◽  
...  
Keyword(s):  
Immune System ◽  
High Throughput Sequencing ◽  
Pure Water ◽  
Structure And Function ◽  
Oral Microbiome ◽  
Oral Microbiota ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
And Function

AbstractSucrose, xylose, and saccharin are commonly used beverage additives and long-term consumption of these compounds inevitably affects the oral immune system and the composition of oral microbiomes. In this study, we used 24 Sprague Dawley rats divided into four groups, i.e., sucrose, saccharin, xylose, or pure water treated over an eight week period to evaluate any changes in the composition, community structure, and function of the oral microbiomes. At the end of the treatment period, we collected oral microbiome samples from each animal and subjected them to high-throughput sequencing. We also used ELISA to determine the concentration of salivary immunoglobulin in these rats to reveal the effect of sweetener on the oral immune system. Sequencing results demonstrated that Firmicutes and Proteobacteria, remained the predominant phyla, but we found that the oral microbial diversity of rats drinking sucrose water was significantly higher than that of the other groups. Our results indicate that drinking water supplemented with sweeteners may influence oral immunity as well as the composition, metabolic function, and diversity of the oral microbiota, thereby disrupting the oral microbiome.

scholarly journals The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Zanelle Bekker ◽  
Andrew Walubo ◽  
Jan B. du Plessis
Keyword(s):  
Immune System ◽  
Liver Injury ◽  
Rat Model ◽  
Chronic Phase ◽  
Therapeutic Strategies ◽  
Cell Swelling ◽  
Sprague Dawley ◽  
Immune Parameters ◽  
Sprague Dawley Rats

In this study, the role of the immune system in nevirapine- (NVP-) induced subclinical liver injury was investigated by observing for changes of some immune parameters during the initial stages of NVP-induced hepatotoxicity in a rat model. In the acute phase, two test-groups of 10 Sprague-Dawley rats each were administered with bacterial lipopolysaccharide (LPS) or saline (S) intraperitoneally, followed by oral NVP, after which 5 rats from each group were sacrificed at 6 and 24 hours. For the chronic phase, two groups of 15 rats each received daily NVP, and on days 7, 14, and 21, five rats from each group were administered with either LPS or S, followed by that day’s NVP dose, and were sacrificed 24 hours later. NVP caused liver injury up to seven days and progressively increased IL-2 and IFN-γ levels and lymphocyte count over the 21 days. NVP-induced liver injury was characterized by apoptosis and degeneration changes, while, for LPS, it was cell swelling, leukostasis, and portal inflammation. Coadministration of NVP and LPS attenuated NVP-induced liver injury. In conclusion, the immune system is involved in NVP toxicity, and the LPS effects may lay the clue to development of therapeutic strategies against NVP-induced hepatotoxicity.

scholarly journals REPRODUCTIVE STUDY II : PRENATAL AND POSTNATAL DEVELOPMENT STUDY WITH CANDOXATRIL IN SPRAGUE-DAWLEY RATS

1998 ◽  
Vol 23 (SupplementV) ◽  
pp. 671-679
Author(s):  
Masao HORIMOTO ◽  
Rieko ITO ◽  
Yuji ISOBE ◽  
Masanori SAKIMURA ◽  
Masakatsu TACHIBANA
Keyword(s):  
Postnatal Development ◽  
Sprague Dawley ◽  
Development Study ◽  
Sprague Dawley Rats ◽  
Prenatal And Postnatal Development ◽  
Reproductive Study

Fish Consumption and Other Characteristics of Reproductive-Aged Michigan Anglers—a Potential Population for Studying the Effects of Consumption of Great Lakes Fish On Reproductive Health

1996 ◽  
Vol 12 (3-4) ◽  
pp. 347-359 ◽  
Author(s):  
Jeanne M. Courval ◽  
Jane V. Dehoog ◽  
Claudia B. Holzman ◽  
Eugene M. Tay ◽  
Lawrence Fischer ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Great Lakes ◽  
Fish Consumption ◽  
Reproductive Age ◽  
Human Reproduction ◽  
Potential Population ◽  
Low Levels ◽  
The Impact ◽  
Reproductive Study ◽  
Screening Survey

There has been considerable interest in the benefits and risks of eating Great Lakes fish, particularly with regard to reproductive health. We report the results of a survey conducted from 1993-1995 among Michigan anglers. The survey was designed to identify a reproductive-aged cohort of persons who consume high or low levels of Great Lakes fish in order to study the impact of polyhalogenated biphenyl (PHB) compounds and other toxins on human reproduction outcomes. Using fishing license data obtained from the Michigan Department of Natural Resources, we identified anglers of early reproductive age (18-34 years) in ten Michigan counties. The screening survey ascertained demographic, behavioral, fish consumption, and reproductive history information on anglers and their partners. Over 4,000 angler households were contacted. One thousand nine hundred fifty questionnaires were returned from 1,168 households. The median age of respondents was 30 years; 58% were male and 64% reported being married. Slightly more than one-half the respondents had attended or graduated from college, and less than 10% had not completed high school. In the past year, most respondents (46%) reported having eaten sport-caught fish 1-12 times, while 20% reported having eaten no sport-caught fish; 20% had consumed 13-24 meals. More sport-caught fish was consumed in the spring and summer than in the fall and winter, and males reported eating more fish than females. About 43% of our respondents reported that they intend to have one or more children in the next five years. Of these respondents, 287 couples had no identified impairments to reproduction and therefore would be eligible to participate in the future reproductive study.

Sign in / Sign up

Export Citation Format

Share Document