Leukocytes Infiltrating the Submandibular Glands of NOD Mice Express E-cadherin

2000 ◽  
Vol 15 (4) ◽  
pp. 387-393 ◽  
Author(s):  
Thomas R Esch ◽  
Malin V Jonsson ◽  
Valerie A Levanos ◽  
Jennifer D Poveromo ◽  
Barbara C Sorkin
Keyword(s):  
Nod Mice ◽  
Submandibular Glands ◽  
E Cadherin

scholarly journals CD4/CD8 Antibodies Reduce Histopathological Damage in Salivary Glands of Spontaneously Diabetic Mice

2019 ◽  
Vol 26 (2) ◽  
pp. 149-157
Author(s):  
Raphael Oliveira Ramos Franco Netto ◽  
Eliézer Guimarães Moura ◽  
Luan Oenning Col ◽  
Magda Jaciara Barros ◽  
Juliana de Almeida Rodrigues Franco Netto ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Nod Mice ◽  
Insulin Receptors ◽  
Nonparametric Test ◽  
Diabetic Mice ◽  
Parotid Glands ◽  
Submandibular Glands ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Abstract Background and aims: Diabetes affects the metabolism promoting damage in different tissues, including salivary glands. Current treatments, such as insulin, are ineffective to recovery of these tissues. In this aspect, the immunotherapy has been tested, but it can be inefficient as an agent for the control of damage caused by diabetes. The aim of this study to evaluate the association in anti-CD4 and anti-CD8 monoclonal antibody in the recovery of salivary glands of diabetic NOD mice. Material and methods: Fifteen spontaneously diabetic mice (NOD) were divided into three groups with 5 animals each: group I (Balb/C control mice), group II (untreated NOD mice), group III (NOD mice treated with CD4 and CD8 antibodies). The CD4 and CD8 antibodies (IMUNY, Rheabiotech Ltda, Brazil) were administered by intravenously injections (25 ug/days: 0, 7, 14, and 21). After treatment salivary glands samples were analyzed by immunofluorescence, microscopy, light microscopy and stereology. (ethical approval process: 304/11), Analysis of variance (ANOVA) and Kruskal-Wallis nonparametric test were used. Results: Elevated levels of glucose (mg/dl) were observed in untreated animals (group II) (605.25 ± 31.23, p≤0.05), whereas in treated animals (group III), were noted a decrease in these levels (464.77 ± 39.66, p≤0.05). Tissue restructure, characterized by cell volume recovery, also was observed in group III (nuclear volume of parotid glands: (109.91 ± 02.03, p≤0.05) and submandibular glands: (107.52 ± 02, p≤0.05) (cytoplasmic volume of parotid glands: (356.14 ± 26.34, p≤0.05) and submandibular glands: (331.22 ± 32.11, p≤0.05). Intense signaling (+++) of insulin receptors was observed in animals of group I. On the other hand, in group II was noted a reduction of these receptors (+). In treated animals (group III) were observed a recovery of the insulin receptors (+++). Conclusions: This treatment was effective in the recovery of salivary acinar cells, contributed also to homeostasis of body metabolism. Thus, this immunomodulation promoted a beneficial effect on the recovery of these tissues.

scholarly journals Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy

2007 ◽  
Vol 56 (8) ◽  
pp. 2566-2574 ◽  
Author(s):  
Muhammad S. Soyfoo ◽  
Carine De Vriese ◽  
Huguette Debaix ◽  
Maria D. Martin-Martinez ◽  
Chantal Mathieu ◽  
...  
Keyword(s):  
Nod Mice ◽  
Aquaporin 5 ◽  
Submandibular Glands ◽  
Autoimmune Exocrinopathy

622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-170
Author(s):  
Maxine G. Tran ◽  
Miguel A. Esteban ◽  
Peter D. Hill ◽  
Ashish Chandra ◽  
Tim S. O'Brien ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Von Hippel Lindau ◽  
E Cadherin ◽  
Cell Cell

614: Polymorphisms in the E-Cadherin (CDH1) Gene Promoter and the Risk of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 198-198
Author(s):  
Lambertus A. Kiemeney ◽  
Kjeld P. Van Houwelingen ◽  
Manon Bogaerts ◽  
J. Alfred Witjes ◽  
Dorine W. Swinkels ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Gene Promoter ◽  
Cdh1 Gene ◽  
E Cadherin

743: Methylation of the E-Cadherin and the TIMP-3 Genes are Positive Prognostic Markers for Patients with Non-Muscle Invasive Bladder Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 197-197
Author(s):  
Martin G. Friedrich ◽  
Gangning Liang ◽  
Marieta I. Toma ◽  
Daniel J. Weisenberger ◽  
Jonathan C. Cheng ◽  
...  
Keyword(s):  
Bladder Carcinoma ◽  
Prognostic Markers ◽  
Muscle Invasive ◽  
E Cadherin

733: The Prognostic Value of E-Cadherin, Alpha-, and Beta-Catenin in Invasive Bladder Cancer Patients: Long Term Follow-Up Study

2004 ◽  
Vol 171 (4S) ◽  
pp. 194-195
Author(s):  
Kyoichi Tomita ◽  
Haruki Kume ◽  
Keishi Kashibuchi ◽  
Satoru Muto ◽  
Shigeo Horie ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Invasive Bladder Cancer ◽  
Beta Catenin ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
E Cadherin

1412: Assessment of a Cleaved Product of E-Cadherin as a Serum Biomarker with Predictive Value for Prostate Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 383-383
Author(s):  
Rainer Kuefer ◽  
Matthias D. Hofer ◽  
Christoph Zorn ◽  
Bjoern G. Volkmer ◽  
Juergen E. Gschwend ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Predictive Value ◽  
Serum Biomarker ◽  
E Cadherin

410: Cleavage of E-Cadherin and the Role of an 80KDa Fragment in the Metastatic Progression of Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 108-108
Author(s):  
Rainer Kuefer ◽  
Kathleen Day ◽  
Jonathan Rios-Doria ◽  
Matthias Hofer ◽  
Arul Chinnaiyan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Metastatic Progression ◽  
E Cadherin
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