Evidence for Sexual Differentiation of Glia in Rat Brain

1996 ◽  
Vol 30 (4) ◽  
pp. 553-562 ◽  
Author(s):  
Jessica A. Mong ◽  
Rachel L. Kurzweil ◽  
Aline M. Davis ◽  
Meredith S. Rocca ◽  
Margaret M. Mccarthy
1975 ◽  
Vol 67 (3) ◽  
pp. 419-424 ◽  
Author(s):  
CYNTHIA DOUGHTY ◽  
JANET E. BOOTH ◽  
P. G. McDONALD ◽  
R. F. PARROTT

SUMMARY Groups of neonatal female rats were treated for the first 5 days of life with oestradiol-17β, oestradiol benzoate or a synthetic oestrogen, 11β-methoxy-17-ethynyl-1,3,5(10)-oestratriene-3,17β-diol (RU 2858), in daily doses ranging from 0·5 to 1000 ng. Oestradiol-17β had no effect on adult ovarian cyclicity or sexual receptivity after ovariectomy and oestrogen + progesterone treatment. Ovarian cyclicity was prevented by 100 ng or more oestradiol benzoate/day, and by all doses of RU 2858. Only rats receiving 50 ng oestradiol benzoate/ day or 0·5 ng RU 2858/day showed normal receptivity. The defeminizing action of RU 2858 was at least 100 times greater than that of oestradiol benzoate; it is suggested that this greater potency is due to the low affinity of RU 2858 for the oestradiol-binding protein in the plasma of neonatal rats. These results indicate that defeminization of the neonatal rat brain can be induced by physiological amounts of oestrogen, and are discussed with reference to the action of testosterone.


1986 ◽  
Vol 108 (2) ◽  
pp. 281-285 ◽  
Author(s):  
A. Perakis ◽  
F. Stylianopoulou

ABSTRACT Exposure of the developing female brain to a 5α-dihydrotestosterone surge on day 18 of gestation resulted in defeminization and slight masculinization of the brain. In contrast, abolition of the androgenic effects of the testosterone peak naturally occurring in male fetuses on day 18 of gestation by exposure of the developing male brain to cyproterone acetate, at that time, resulted in demasculinization while feminization was not affected. On the basis of these results, we suggest that both the prenatal testosterone peak and the high testosterone levels occurring in males neonatally are necessary for aromatization sufficient to effect complete male rat brain sexual differentiation. J. Endocr. (1986) 108, 281–285


2001 ◽  
Vol 73 (6) ◽  
pp. 387-396 ◽  
Author(s):  
Margaret Giannakopoulou ◽  
Evangelos Bozas ◽  
Helen Philippidis ◽  
Fotini Stylianopoulou

1995 ◽  
Vol 691 (1-2) ◽  
pp. 229-234 ◽  
Author(s):  
Sylvia Kühnemann ◽  
Theodore J. Brown ◽  
Richard B. Hochberg ◽  
Neil J. MacLusky

2000 ◽  
Vol 114 (5) ◽  
pp. 923-933 ◽  
Author(s):  
Aline M. Davis ◽  
David R. Grattan ◽  
Margaret M. McCarthy

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