Sex hormone receptors in the hypothalamus and their role in sexual differentiation of the male rat brain

1986 ◽  
Vol 101 (4) ◽  
pp. 525-528
Author(s):  
I. V. Shishkina ◽  
V. N. Babichev ◽  
L. Yu. Ozol'
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation ◽  
Hormone Receptors ◽  
Sex Hormone ◽  
Male Rat

Effects of a prenatal androgen peak on rat brain sexual differentiation

1986 ◽  
Vol 108 (2) ◽  
pp. 281-285 ◽  
Author(s):  
A. Perakis ◽  
F. Stylianopoulou
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation ◽  
Cyproterone Acetate ◽  
Male Rat ◽  
Testosterone Levels ◽  
Naturally Occurring ◽  
Female Brain ◽  
Brain Sexual Differentiation ◽  
Prenatal Androgen ◽  
The Brain

ABSTRACT Exposure of the developing female brain to a 5α-dihydrotestosterone surge on day 18 of gestation resulted in defeminization and slight masculinization of the brain. In contrast, abolition of the androgenic effects of the testosterone peak naturally occurring in male fetuses on day 18 of gestation by exposure of the developing male brain to cyproterone acetate, at that time, resulted in demasculinization while feminization was not affected. On the basis of these results, we suggest that both the prenatal testosterone peak and the high testosterone levels occurring in males neonatally are necessary for aromatization sufficient to effect complete male rat brain sexual differentiation. J. Endocr. (1986) 108, 281–285

scholarly journals Influence of LHRH on sex hormone receptors in the amygdala of the male rat

2004 ◽  
Vol 54 (5-6) ◽  
pp. 347-356 ◽  
Author(s):  
Drekic Dmitar ◽  
Mrvic-Jovicic Verica ◽  
Zoric Zoran ◽  
Djelic Dijana ◽  
Blagojevic Zdenka ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Sex Hormone ◽  
Male Rat

scholarly journals Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1169
Author(s):  
Hiroki Ide ◽  
Hiroshi Miyamoto
Keyword(s):  
Bladder Cancer ◽  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Surgical Therapy ◽  
Urothelial Cancer ◽  
Hormone Receptors ◽  
Estrogen Receptor Α ◽  
Vital Role ◽  
Sex Hormone ◽  
Sex Steroid Hormone

There have been critical problems in the non-surgical treatment for bladder cancer, especially residence to intravesical pharmacotherapy, including BCG immunotherapy, cisplatin-based chemotherapy, and radiotherapy. Recent preclinical and clinical evidence has suggested a vital role of sex steroid hormone-mediated signaling in the progression of urothelial cancer. Moreover, activation of the androgen receptor and estrogen receptor pathways has been implicated in modulating sensitivity to conventional non-surgical therapy for bladder cancer. This may indicate the possibility of anti-androgenic and anti-estrogenic drugs, apart from their direct anti-tumor activity, to function as sensitizers of such conventional treatment. This article summarizes available data suggesting the involvement of sex hormone receptors, such as androgen receptor, estrogen receptor-α, and estrogen receptor-β, in the progression of urothelial cancer, focusing on their modulation for the efficacy of conventional therapy, and discusses their potential of overcoming therapeutic resistance.

scholarly journals Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors.

2004 ◽  
Vol 112 (5) ◽  
pp. 516-523 ◽  
Author(s):  
Kelly J Gauger ◽  
Yoshihisa Kato ◽  
Koichi Haraguchi ◽  
Hans-Joachim Lehmler ◽  
Larry W Robertson ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Polychlorinated Biphenyls ◽  
Rat Brain ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Fetal Rat ◽  
Fetal Rat Brain

Immunocytochemical Localization of Thyroid Hormone Receptors in the Adult Rat Brain

Thyroid ◽  
1991 ◽  
Vol 1 (2) ◽  
pp. 173-184 ◽  
Author(s):  
J. PUYMIRAT ◽  
M. MIEHE ◽  
R. MARCHAND ◽  
L. SARLIEVE ◽  
J.H. DUSSAULT
Keyword(s):  
Thyroid Hormone ◽  
Rat Brain ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Immunocytochemical Localization ◽  
Adult Rat ◽  
Adult Rat Brain
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