Granulin Precursor Gene: A Sex Steroid-Inducible Gene Involved in Sexual Differentiation of the Rat Brain

2002 ◽  
Vol 75 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Masatoshi Suzuki ◽  
Masugi Nishiahara
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation ◽  
Sex Steroid ◽  
Inducible Gene

EFFECTS OF OESTRADIOL-17β, OESTRADIOL BENZOATE AND THE SYNTHETIC OESTROGEN RU 2858 ON SEXUAL DIFFERENTIATION IN THE NEONATAL FEMALE RAT

1975 ◽  
Vol 67 (3) ◽  
pp. 419-424 ◽  
Author(s):  
CYNTHIA DOUGHTY ◽  
JANET E. BOOTH ◽  
P. G. McDONALD ◽  
R. F. PARROTT
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation ◽  
Neonatal Rat ◽  
Female Rats ◽  
Sexual Receptivity ◽  
Female Rat ◽  
Neonatal Rats ◽  
Oestradiol Benzoate ◽  
Ovarian Cyclicity ◽  
Neonatal Rat Brain

SUMMARY Groups of neonatal female rats were treated for the first 5 days of life with oestradiol-17β, oestradiol benzoate or a synthetic oestrogen, 11β-methoxy-17-ethynyl-1,3,5(10)-oestratriene-3,17β-diol (RU 2858), in daily doses ranging from 0·5 to 1000 ng. Oestradiol-17β had no effect on adult ovarian cyclicity or sexual receptivity after ovariectomy and oestrogen + progesterone treatment. Ovarian cyclicity was prevented by 100 ng or more oestradiol benzoate/day, and by all doses of RU 2858. Only rats receiving 50 ng oestradiol benzoate/ day or 0·5 ng RU 2858/day showed normal receptivity. The defeminizing action of RU 2858 was at least 100 times greater than that of oestradiol benzoate; it is suggested that this greater potency is due to the low affinity of RU 2858 for the oestradiol-binding protein in the plasma of neonatal rats. These results indicate that defeminization of the neonatal rat brain can be induced by physiological amounts of oestrogen, and are discussed with reference to the action of testosterone.

Evidence for Sexual Differentiation of Glia in Rat Brain

1996 ◽  
Vol 30 (4) ◽  
pp. 553-562 ◽  
Author(s):  
Jessica A. Mong ◽  
Rachel L. Kurzweil ◽  
Aline M. Davis ◽  
Meredith S. Rocca ◽  
Margaret M. Mccarthy
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation

Effects of a prenatal androgen peak on rat brain sexual differentiation

1986 ◽  
Vol 108 (2) ◽  
pp. 281-285 ◽  
Author(s):  
A. Perakis ◽  
F. Stylianopoulou
Keyword(s):  
Rat Brain ◽  
Sexual Differentiation ◽  
Cyproterone Acetate ◽  
Male Rat ◽  
Testosterone Levels ◽  
Naturally Occurring ◽  
Female Brain ◽  
Brain Sexual Differentiation ◽  
Prenatal Androgen ◽  
The Brain

ABSTRACT Exposure of the developing female brain to a 5α-dihydrotestosterone surge on day 18 of gestation resulted in defeminization and slight masculinization of the brain. In contrast, abolition of the androgenic effects of the testosterone peak naturally occurring in male fetuses on day 18 of gestation by exposure of the developing male brain to cyproterone acetate, at that time, resulted in demasculinization while feminization was not affected. On the basis of these results, we suggest that both the prenatal testosterone peak and the high testosterone levels occurring in males neonatally are necessary for aromatization sufficient to effect complete male rat brain sexual differentiation. J. Endocr. (1986) 108, 281–285

Protooncogene c-fos Involvement in the Molecular Mechanism of Rat Brain Sexual Differentiation

2001 ◽  
Vol 73 (6) ◽  
pp. 387-396 ◽  
Author(s):  
Margaret Giannakopoulou ◽  
Evangelos Bozas ◽  
Helen Philippidis ◽  
Fotini Stylianopoulou
Keyword(s):  
Rat Brain ◽  
Molecular Mechanism ◽  
Sexual Differentiation ◽  
Brain Sexual Differentiation

scholarly journals Sex Steroid Receptors in the Perinatal Rat Brain

1978 ◽  
Vol 18 (3) ◽  
pp. 539-544 ◽  
Author(s):  
IVAN LIEBERBURG ◽  
NEIL J. MACLUSKY ◽  
EDWARD J. ROY ◽  
BRUCE S. MCEWEN
Keyword(s):  
Rat Brain ◽  
Steroid Receptors ◽  
Sex Steroid ◽  
Sex Steroid Receptors

Sexual differentiation of estrogen receptor concentrations in the rat brain: effects of neonatal testosterone exposure

1995 ◽  
Vol 691 (1-2) ◽  
pp. 229-234 ◽  
Author(s):  
Sylvia Kühnemann ◽  
Theodore J. Brown ◽  
Richard B. Hochberg ◽  
Neil J. MacLusky
Keyword(s):  
Estrogen Receptor ◽  
Rat Brain ◽  
Sexual Differentiation
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