Differential Expression of Members of the N-Formylpeptide Receptor Gene Cluster in Human Phagocytes

1994 ◽  
Vol 201 (1) ◽  
pp. 174-179 ◽  
Author(s):  
M. Durstin ◽  
J.L. Gao ◽  
H.L. Tiffany ◽  
D. Mcdermott ◽  
P.M. Murphy
Keyword(s):  
Differential Expression ◽  
Gene Cluster ◽  
Receptor Gene ◽  
Formylpeptide Receptor

Differential Expansion of the N-Formylpeptide Receptor Gene Cluster in Human and Mouse

Genomics ◽  
1998 ◽  
Vol 51 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Ji-Liang Gao ◽  
Hubert Chen ◽  
Jane D. Filie ◽  
Christine A. Kozak ◽  
Philip M. Murphy
Keyword(s):  
Gene Cluster ◽  
Receptor Gene ◽  
Differential Expansion ◽  
Human And Mouse ◽  
Formylpeptide Receptor

Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness

2002 ◽  
Vol 11 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Imran M. Khan ◽  
Erin Singletary ◽  
Adamu Alemayehu ◽  
Shanaka Stanislaus ◽  
Morton P. Printz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Gene Cluster ◽  
Nicotinic Receptor ◽  
Receptor Gene ◽  
Repeated Administration ◽  
Chromosome 8 ◽  
Brown Norway ◽  
Spontaneously Hypertensive ◽  
Nicotinic Agonists ◽  
Nociceptive Responses

Spontaneously hypertensive rats (SHR) exhibit enhanced pressor, heart rate, and nociceptive responses to spinal nicotinic agonists. This accompanies a paradoxical decrease in spinal nicotinic receptor number in SHR compared with normotensive rats. The congenic strain, SHR-Lx, with an introgressed chromosome 8 segment from the normotensive Brown-Norway-Lx strain (BN-Lx) exhibits reduced blood pressure. This segment contains a gene cluster for three nicotinic receptor subunits expressed in the nervous system. We examined the implication of this gene cluster in the enhanced responsiveness of the SHR. Pressor and nociceptive responses to spinal cytisine, a nicotinic agonist, were diminished in SHR-Lx. Moreover, with repeated administration, these responses desensitized faster in SHR-Lx and progenitor BN-Lx than in progenitor SHR/Ola. This implicates the gene cluster in both cardiovascular and nociceptive responses to spinal nicotinic agonists. Since diminished responsiveness to agonist stimulation is greater than the basal blood pressure differences between the strains and the introgressed rat chromosome maps to a quantitative trait locus in human hypertension, polymorphisms in the three nicotinic receptor genes become candidates for altered central control of blood pressure.

scholarly journals Gene cluster lock after pheromone receptor gene choice

2007 ◽  
Vol 26 (14) ◽  
pp. 3423-3430 ◽  
Author(s):  
Daniele Roppolo ◽  
Sarah Vollery ◽  
Chen-Da Kan ◽  
Christian Lüscher ◽  
Marie-Christine Broillet ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Receptor Gene ◽  
Pheromone Receptor

scholarly journals Repellency Mechanism of Natural Guar Gum-Based Film Incorporated with Citral against Brown Planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae)

2022 ◽  
Vol 23 (2) ◽  
pp. 758
Author(s):  
Xiubing Gao ◽  
Xianfeng Hu ◽  
Feixu Mo ◽  
Yi Ding ◽  
Ming Li ◽  
...  
Keyword(s):  
Differential Expression ◽  
Guar Gum ◽  
Defense Mechanism ◽  
Insect Pests ◽  
Odorant Receptor ◽  
Receptor Gene ◽  
Insect Pest ◽  
Brown Planthopper ◽  
Sequencing Analysis ◽  
Or Gene

Using of plant essential oil that coevolved as a defense mechanism against agriculture insects is an alternative means of controlling many insect pests. In order to repel brown planthoppers (BPHs), the most notorious rice insect pest, a new film based on guar gum incorporated with citral (GC film) was formulated, which was effective while being environmentally friendly. In this paper, the effect and mechanism of GC film repellency against BPHs were determined. Repellent activity test and olfactory reaction analysis showed that GC film had repellency effect against BPHs, with repellency of 60.00% and 73.93%, respectively. The result of olfactory reaction indicated that GC film repellency against BPHs relied on smell. EPG analysis showed the proportion and mean duration of np waveform were significantly higher than in CK and increased following the treatment concentration, which indicated that GC film affected the recognition of BPHs to rice. Further analysis by RNA sequencing analysis showed a total of 679 genes were significantly upregulated and 284 genes were significantly downregulated in the BPHs fed on the rice sprayed with GC film compared to control. Odorant-binding protein (OBP) gene 797 and gustatory receptor gene (GR)/odorant receptor (OR) gene 13110 showed a significant decrease in differential expression and significant increase in differential expression, respectively. There were 0.66 and 2.55 differential expression multiples between treated BPHs and control, respectively. According to the results described above, we reasoned that GC film repellency against BPHs due to smell, by release of citral, caused the recognition difficulties for BPHs to rice, and OBP gene 797 and GR/OR gene 13110 appeared to be the crucial candidate genes for GC film repellency against BPHs. The present study depicted a clear and consistent repellency effect for GC film against BPHs and preliminarily clarified the mechanism of GC film as a repellent against BPHs, which might offer an alternative approach for control of BPHs in the near future. Our results could also help in the development and improvement of GC films.

scholarly journals Seminal Plasma Triggers the Differential Expression of the Glucocorticoid Receptor (NR3C1/GR) in the Rabbit Reproductive Tract

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2158
Author(s):  
Mateo Ruiz-Conca ◽  
Jaume Gardela ◽  
Amaia Jauregi-Miguel ◽  
Cristina A. Martinez ◽  
Heriberto Rodríguez-Martinez ◽  
...  
Keyword(s):  
Differential Expression ◽  
Seminal Plasma ◽  
Time Course ◽  
Reproductive Tract ◽  
Receptor Gene ◽  
Early Embryo ◽  
Female Reproductive Tract ◽  
Relevant Role ◽  
Morula Stage ◽  
Embryo Transport

Rabbits are interesting as research animal models for reproduction, due to their condition of species of induced ovulation, with the release of endogenous gonadotropin-releasing hormone (GnRH) due to coitus. Glucocorticoid (GC) signaling, crucial for physiological homeostasis, is mediated through a yet unclear mechanism, by the GC receptor (NR3C1/GR). After mating, the female reproductive tract undergoes dynamic modifications, triggered by gene transcription, a pre-amble for fertilization and pregnancy. This study tested the hypothesis that when ovulation is induced, the expression of NR3C1 is influenced by sperm-free seminal plasma (SP), similarly to after mating (whole semen), along the different segments of the internal reproductive tract of female rabbits. Semen (mating) was compared to vaginal infusion of sperm-free SP (Experiment 1), and changes over time were also evaluated, i.e., 10, 24, 36, 68, and 72 h post-mating, corresponding to specific stages, i.e., ovulation, fertilization, and the interval of early embryo development up to the morula stage (Experiment 2). All does were treated with GnRH to induce ovulation. Samples were retrieved from seven segments of the reproductive tract (from the cervix to infundibulum), at 20 h post-mating or sperm-free SP infusion (Experiment 1) or at 10, 24, 36, 68, and 72 h post-mating (Experiment 2). Gene expression of NR3C1 was analyzed by qPCR. Results showed an increase in NR3C1 expression in the infundibulum compared to the other anatomical regions in the absence of spermatozoa when sperm-free SP infusion was performed (Experiment 1). Moreover, during the embryo transport through the oviduct, the distal isthmus was time-course upregulated, especially at 72 h, when morulae are retained in this anatomical region, while it was downregulated in the distal uterus at 68 h (Experiment 2). The overall results suggest that NR3C1, the GC receptor gene, assessed in the reproductive tract of does for the first time, shows differential expression changes during the interval of oviductal and uterine embryo transport that may imply a relevant role of the GC action, not only close to the site of ovulation and fertilization, but also in the endometrium.

scholarly journals Evolutionary Story of the Low/Medium-Affinity IgG Fc Receptor Gene Cluster

2019 ◽  
Vol 10 ◽  
Author(s):  
Julien Lejeune ◽  
Guillaume Brachet ◽  
Hervé Watier
Keyword(s):  
Gene Cluster ◽  
Receptor Gene ◽  
Fc Receptor ◽  
Evolutionary Story
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