Intranuclear Aggregation of Nonexpanded Ataxin-3 in Marinesco Bodies of the Nonhuman Primate Substantia Nigra

2002 ◽  
Vol 176 (1) ◽  
pp. 117-121 ◽  
Author(s):  
Mattias Kettner ◽  
Dirk Willwohl ◽  
Gene B. Hubbard ◽  
U. Rüb ◽  
Edward J. Dick ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Nonhuman Primate ◽  
Marinesco Bodies

Parallel enlargement of Marinesco bodies and nuclei and progressive deposition of p62 in pigmented neurons of the substantia nigra

2020 ◽  
Vol 40 (4) ◽  
pp. 328-335
Author(s):  
Ryota Amano ◽  
Shuta Toru ◽  
Michio Yamane ◽  
Masanobu Kitagawa ◽  
Katsuiku Hirokawa ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Marinesco Bodies

Distribution of Marinesco Bodies in Human Substantia Nigra Neurons

2016 ◽  
Vol 46 (7) ◽  
pp. 839-842
Author(s):  
I. P. Grigor’ev ◽  
V. V. Gusel’nikova ◽  
E. G. Sukhorukova ◽  
D. E. Korzhevskii
Keyword(s):  
Substantia Nigra ◽  
Marinesco Bodies ◽  
Human Substantia Nigra

scholarly journals The Antiparkinsonian and Antidyskinetic Mechanisms ofMucuna pruriensin the MPTP-Treated Nonhuman Primate

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Christopher A. Lieu ◽  
Kala Venkiteswaran ◽  
Timothy P. Gilmour ◽  
Anand N. Rao ◽  
Andrew C. Petticoffer ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Substantia Nigra ◽  
Nonhuman Primate ◽  
Chronic Treatment ◽  
Water Extract ◽  
Neuronal Firing ◽  
Mucuna Pruriens ◽  
Drug Induced ◽  
Substantia Nigra Reticulata ◽  
Firing Properties

Chronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias.Mucuna pruriensendocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias. We evaluated the effects ofMucuna pruriensto determine if its underlying mechanistic actions are exclusively due to LD. We first compared MPEP with and without carbidopa (CD), and LD+CD in hemiparkinsonian (HP) monkeys. Each treatment ameliorated parkinsonism. We then compared the neuronal firing properties of the substantia nigra reticulata (SNR) and subthalamic nucleus (STN) in HP monkeys with MPEP+CD and LD+CD to evaluate basal ganglia circuitry alterations. Both treatments decreased SNR firing rate compared to HP state. However, LD+CD treatments significantly increased SNR bursting firing patterns that were not seen with MPEP+CD treatments. No significant changes were seen in STN firing properties. We then evaluated the effects of a water extract of MPEP. Oral MPWE ameliorated parkinsonism without causing drug-induced dyskinesias. The distinctive neurophysiological findings in the basal ganglia and the ability to ameliorate parkinsonism without causing dyskinesias strongly suggest thatMucuna pruriensacts through a novel mechanism that is different from that of LD.

scholarly journals Embryonic Substantia Nigra Grafts Show Directional Outgrowth to Cografted Striatal Grafts and Potential for Pathway Reconstruction in Nonhuman Primate

2008 ◽  
Vol 17 (4) ◽  
pp. 427-444 ◽  
Author(s):  
J. R. Sladek ◽  
K. B. Bjugstad ◽  
T. J. Collier ◽  
E. A. Bundock ◽  
B. C. Blanchard ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Nonhuman Primate ◽  
Pathway Reconstruction ◽  
Striatal Grafts

scholarly journals The Spatial Organization of the Intranuclear Structures of Human Brain Dopaminergic Neurons

Acta Naturae ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 81-88 ◽  
Author(s):  
D. E. Korzhevskii ◽  
V. V. Gusel’nikova ◽  
O. V. Kirik ◽  
E. G. Sukhorukova ◽  
I. P. Grigorev
Keyword(s):  
Substantia Nigra ◽  
Dopaminergic Neurons ◽  
Spatial Organization ◽  
Molecular Mechanisms ◽  
Three Dimensional ◽  
Selective Vulnerability ◽  
Confocal Laser ◽  
Double Labeling ◽  
Dimensional Reconstruction ◽  
Marinesco Bodies

We studied the intranuclear localization of protein nucleophosmin (B23) and ubiquitin in the dopaminergic neurons of human substantia nigra (n = 6, age of 25-87 years) using immunohistochemistry and confocal laser microscopy. Intranuclear ubiquitin-immunopositive bodies that morphologically correspond to Marinesco bodies were found to be present in substantia nigra dopaminergic (tyrosine hydroxylase-immunopositive) neurons but absent in non-dopaminergic neurons. The number of bodies varied from 0 to 6 per cell nucleus. Nucleophosmin (B23) was found in the neuronal nucleolus, with the nucleolus size being constant in the nigral neurons of each individual brain. All the observed neurons had only one large nucleolus with intense nucleophosmin immunoreactivity and a lightly stained region (1-2 m in diameter) that apparently represents the giant fibrillar center (GFC). An intensely immunostained nucleophosmin-containing granule was often observed at the GFC periphery. Double labeling demonstrated that nucleophosmin-immunoreactive nucleolus and ubiquitin-immunoreactive Marinesco bodies can occur both closely to and remotely from each other. Three-dimensional reconstruction indicates that rounded Marinesco bodies are polymorphic and often have a complex shape, with some flattening and concavities, which may be associated with contact not only with the nucleolus, but also, presumably, with other intranuclear structures free of ubiquitin or nucleophosmin. Ubiquitin-immunoreactive structures with a relatively small size (up to 1 m in length) and various clastosome-like shapes (Lafarga et al., 2002) often occur near Marinesco bodies. There were no cases of detection of ubiquitin in the nucleoli of dopaminergic neurons and nucleophosmin/B23 in typical Marinesco bodies. The obtained information may be helpful in unraveling the molecular mechanisms of the selective vulnerability of substantia nigra dopaminergic neurons to damaging factors.

scholarly journals Substantia Nigra Marinesco Bodies Are Associated with Decreased Striatal Expression of Dopaminergic Markers

2004 ◽  
Vol 63 (4) ◽  
pp. 329-337 ◽  
Author(s):  
Thomas G. Beach ◽  
Douglas G. Walker ◽  
Lucia I. Sue ◽  
Amanda Newell ◽  
Charles C. Adler ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Marinesco Bodies

scholarly journals Marinesco bodies and substantia nigra neuron density in Parkinson's disease

2017 ◽  
Vol 43 (7) ◽  
pp. 621-630 ◽  
Author(s):  
R. D. Abbott ◽  
J. S. Nelson ◽  
G.W. Ross ◽  
J. H. Uyehara-Lock ◽  
C. M. Tanner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Neuron Density ◽  
Substantia Nigra Neuron ◽  
Marinesco Bodies
Sign in / Sign up

Export Citation Format

Share Document