Intracytoplasmic inclusion bodies of the thalamus and the substantia nigra, and Marinesco bodies in myotonic dystrophy: a quantitative morphological study

1989 ◽  
Vol 77 (4) ◽  
pp. 350-356 ◽  
Author(s):  
S. Ono ◽  
K. Inoue ◽  
T. Mannen ◽  
S. Mitake ◽  
T. Shirai ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Myotonic Dystrophy ◽  
Inclusion Bodies ◽  
Morphological Study ◽  
Intracytoplasmic Inclusion ◽  
Intracytoplasmic Inclusion Bodies ◽  
Marinesco Bodies

Intracytoplasmic inclusion bodies of the substantia nigra in myotonic dystrophy

1997 ◽  
Vol 148 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Seiitsu Ono ◽  
Keiichi Takahashi ◽  
Yoshihiro Fukuoka ◽  
Kenji Jinnai ◽  
Fumio Kanda ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Myotonic Dystrophy ◽  
Inclusion Bodies ◽  
Intracytoplasmic Inclusion ◽  
Intracytoplasmic Inclusion Bodies

Immunohistochemical study of intracytoplasmic inclusion bodies of the thalamus in myotonic dystrophy

1996 ◽  
Vol 140 (1-2) ◽  
pp. 96-100 ◽  
Author(s):  
Seiitsu Ono ◽  
Keiichi Takahashi ◽  
Fumio Kanda ◽  
Yoshihiro Fukuoka ◽  
Kenji Jinnai ◽  
...  
Keyword(s):  
Myotonic Dystrophy ◽  
Inclusion Bodies ◽  
Immunohistochemical Study ◽  
Intracytoplasmic Inclusion ◽  
Intracytoplasmic Inclusion Bodies

Intracytoplasmic inclusion bodies in the chondrocytes of type I lethal achondrogenesis

1976 ◽  
Vol 7 (6) ◽  
pp. 667-673 ◽  
Author(s):  
Sheng-S. Yang ◽  
Kathleen P. Heidelberger ◽  
Jay Bernstein
Keyword(s):  
Inclusion Bodies ◽  
Type I ◽  
Intracytoplasmic Inclusion ◽  
Intracytoplasmic Inclusion Bodies

Naturally Occurring Infectious Fibroma in the Domestic Rabbit

1973 ◽  
Vol 10 (6) ◽  
pp. 509-519 ◽  
Author(s):  
L. T. Pulley ◽  
J. N. Shively
Keyword(s):  
Tumor Cells ◽  
Inclusion Bodies ◽  
Inflammatory Cells ◽  
Naturally Occurring ◽  
Intracytoplasmic Inclusion ◽  
Domestic Rabbit ◽  
Cutaneous Tumor ◽  
Intracytoplasmic Inclusion Bodies ◽  
Vascular Channels ◽  
Domestic Rabbits

Infectious fibromas developed in eight domestic rabbits that were all kept in outside cages. Each rabbit had a single cutaneous tumor. Six of these tumors, which were studied by light microscopy, consisted of tumor cells resembling fibroblasts and large areas of inflammation. The overlying epidermis was hyperplastic and contained easily recognizable intracytoplasmic inclusion bodies. Inclusion bodies were also in subepithelial fibroma cells. Electron microscopy of three of these tumors revealed typical pox-virus inclusions, sites of viral replication, maturation, and mature particles in epithelial cells of the epidermis and in subepithelial tumor cells. Virus was not seen in inflammatory cells or leukocytes within vascular channels.

scholarly journals A Patient with Proximal Myotonic Myopathy and Parkinsonism

2002 ◽  
Vol 29 (2) ◽  
pp. 188-190 ◽  
Author(s):  
Kon Chu ◽  
Jin-Whan Cho ◽  
Eun-Chol Song ◽  
Beom S. Jeon
Keyword(s):  
Case Report ◽  
Myotonic Dystrophy ◽  
Inclusion Bodies ◽  
Neurodegenerative Disorder ◽  
Case Reports ◽  
Proximal Myotonic Myopathy ◽  
Intracytoplasmic Inclusion Bodies ◽  
Gene Study ◽  
Stooped Posture

Abstract:Introduction:There are two case reports of patients who had proximal myotonic myopathy (PROMM) / myotonic dystrophy (DM) Type 1 and parkinsonism. The combination of myotonic myopathy and parkinsonism is so rare that it may appear to be just a coincidence. However, previous neuropathological examinations of patients who had myotonic dystrophy showed that there were intracytoplasmic inclusion bodies in the nigra and striatum, which raises the possibility that myotonic myopathy may be associated with parkinsonism. In this report we describe a patient with PROMM and a clinically definite parkinsonism to highlight this possibility.Case Report:A 65-year-old man developed proximal muscle weakness, myotonia and atrophy around the age of 55 and was diagnosed as having PROMM at the age of 62. Needle electromyography and muscle biopsy supported the diagnosis. A gene study of the DM Type 1 showed a normal CTG repeat length. At age 63, he developed rest tremor, bradykinesia, hypomimia, stooped posture, and gait disturbance. The postural instability worsened rapidly. The tremor and rigidity were much worse in his right side, where myotonia was more severe. Levodopa therapy was only partially effective.Conclusion:This is a case report of a patient with PROMM that shows an association with a rapidly progressive form of parkinsonism. We suggest that this may be a novel form of a neurodegenerative disorder, which we name ‘Parkinsonism- Myotonic Myopathy-Complex’.

scholarly journals A Case of Contagious Ecthyma (Orf Virus) in a Nonmanipulated Laboratory Dorset Sheep (Ovis aries)

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Gwynne E. Kinley ◽  
Connie W. Schmitt ◽  
Julie Stephens-Devalle
Keyword(s):  
Inclusion Bodies ◽  
Clinical Case ◽  
Ovis Aries ◽  
Orf Virus ◽  
Contagious Ecthyma ◽  
Medial Canthus ◽  
Presumptive Diagnosis ◽  
Intracytoplasmic Inclusion ◽  
Histopathological Evaluation ◽  
Intracytoplasmic Inclusion Bodies

An approximately 5-month-old laboratory wether, originating from a local vendor with a closed flock and maintained on a preventative medicine plan, presented with a continuum of lesions from hemorrhagic papules, vesicles, and pustules, to multifocal necrotic scabs at the commissure of the lips, medial canthus of the left eye, and distal prepuce. A presumptive diagnosis of Orf virus (ORFV) was made and the sheep was euthanized. A full necropsy was performed, and histopathological evaluation of affected tissues revealed multifocal-to-coalescing necrotizing and proliferative cheilitis and dermatitis with eosinophilic intracytoplasmic inclusion bodies. Electron microscopy findings revealed degenerate keratinocytes containing numerous typical 200–300 nm wide cytoplasmic parapoxvirus virions, confirming the diagnosis of ORFV. We believe that this animal developed a clinical case of ORFV either due to an adverse reaction to an ORFV vaccine, or this animal had a case of preexisting ORFV which manifested after arrival at our facility.

ULTRASTRUCTURE OF INTRACYTOPLASMIC INCLUSION BODIES IN HEPATOCYTES OF GRISEOFULVIN-TREATED MICE

1982 ◽  
Vol 32 (6) ◽  
pp. 1067-1074 ◽  
Author(s):  
Kazunori Matsumoto ◽  
Shinichi Ohta ◽  
Satoru Murao ◽  
Junji Shiga
Keyword(s):  
Inclusion Bodies ◽  
Intracytoplasmic Inclusion ◽  
Intracytoplasmic Inclusion Bodies

scholarly journals Morbilliviral Epizootic in Bottlenose Dolphins of the Gulf of Mexico

1996 ◽  
Vol 8 (3) ◽  
pp. 283-290 ◽  
Author(s):  
Thomas P. Lipscomb ◽  
Seamus Kennedy ◽  
Deborah Moffett ◽  
Amy Krafft ◽  
Brenda A. Klaunberg ◽  
...  
Keyword(s):  
Gulf Of Mexico ◽  
Inclusion Bodies ◽  
Bottlenose Dolphins ◽  
Rt Pcr ◽  
Intranuclear Inclusion ◽  
Intracytoplasmic Inclusion ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Intracytoplasmic Inclusion Bodies ◽  
Formalin Fixed

Morbillivirus infection was diagnosed in 35/67 bottlenose dolphins (Tursiops truncatus) from the Gulf of Mexico that stranded from October 1993 through April 1994 in Alabama, Mississippi, and Texas (USA) during periods of increased dolphin standings in each of the 3 states. Diagnosis was based on histologic lesions, immunohistochemical demonstration of morbilliviral antigen, and detection of morbilliviral RNA by a reverse transcriptase polymerase chain reaction (RT-PCR) test performed on formalin-fixed, paraffin-embedded tissue (5 dolphins), on histologic lesions and detection of morbilliviral RNA by RT-PCR performed on formalin-fixed, paraffin-embedded tissue (1 dolphin), and on detection of morbilliviral RNA by RT-PCR performed on unfixed lung samples collected from carcasses with advanced postmortem autolysis (29 dolphins). Histologic lesions included proliferative interstitial pneumonia with syncytial cells and eosinophilic intranuclear and intracytoplasmic inclusion bodies, lymphoid depletion and syncytial cells with eosinophilic intranuclear inclusion bodies in lymph nodes, eosinophilic intracytoplasmic inclusion bodies in transitional epithelium of urinary bladder, and a syncytial cell with eosinophilic intranuclear inclusion bodies in epidermis. Concomitant pulmonary aspergillosis was diagnosed histologically in 4 dolphins. This is the 5th reported morbilliviral epizootic of aquatic mammals and the 2nd involving bottlenose dolphins in the United States.

Terminal osseous dysplasia presenting with intracytoplasmic inclusion bodies in digital fibromas

2018 ◽  
Vol 35 (6) ◽  
pp. e353-e356 ◽  
Author(s):  
Joao R. V. Gontijo ◽  
Wandilza F. dos Santos ◽  
Bernardo Gontijo ◽  
Rudolf Happle
Keyword(s):  
Inclusion Bodies ◽  
Intracytoplasmic Inclusion ◽  
Osseous Dysplasia ◽  
Intracytoplasmic Inclusion Bodies
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