Embryonic Precursor Cells That Express Trk Receptors: Induction of Different Cell Fates by NGF, BDNF, NT-3, and CNTF

1997 ◽  
Vol 144 (2) ◽  
pp. 350-360 ◽  
Author(s):  
Mahesh B. Lachyankar ◽  
Peter J. Condon ◽  
Peter J. Quesenberry ◽  
N.Scott Litofsky ◽  
Lawrence D. Recht ◽  
...  
Keyword(s):  
Precursor Cells ◽  
Trk Receptors ◽  
Cell Fates

scholarly journals Cell fate patterning during C. elegans vulval development

Development ◽  
1993 ◽  
Vol 119 (Supplement) ◽  
pp. 9-18 ◽  
Author(s):  
Russell J. Hill ◽  
Paul W. Sternberg
Keyword(s):  
Cell Fate ◽  
Short Range ◽  
Precursor Cells ◽  
Cell Fates ◽  
Vulval Development ◽  
C Elegans ◽  
Vulval Precursor Cells ◽  
Combined Action ◽  
Anchor Cell ◽  
Inductive Signal

Precursor cells of the vulva of the C. elegans hermaphrodite choose between two vulval cell fates (1° and 2°) and a non-vulval epidermal fate (3°) in response to three intercellular signals. An inductive signal produced by the anchor cell induces the vulval precursors to assume the 1° and 2° vulval fates. This inductive signal is an EGF-like growth factor encoded by the gene lin-3. An inhibitory signal mediated by lin-15, and which may originate from the surrounding epidermis, prevents the vulval precursors from assuming vulval fates in the absence of the inductive signal. A short range lateral signal, which acts through the gene lin-12, regulates the pattern of 1° and 2° fates assumed by the induced vulval precursors. The combined action of the three signals precisely directs the six vulval precursors to adopt a 3° 3° 2° 1° 2 ° 3° pattern of fates. The amount of inductive signal produced by the anchor cell appears to determine the number or vulval precursors that assume vulval fates. The three induced vulval precursors most proximal to the anchor cell are proposed to adopt the 2° 1° 2° pattern of fates in response to a gradient of the inductive signal and also in response to lateral signalling that inhibits adjacent vulval precursor cells from both assuming the 1° fate.

scholarly journals Two nested gonadal inductions of the vulva in nematodes

Development ◽  
1997 ◽  
Vol 124 (1) ◽  
pp. 253-259 ◽  
Author(s):  
M.A. Felix ◽  
P.W. Sternberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Nematode Species ◽  
Precursor Cells ◽  
Evolutionary Change ◽  
Cell Interactions ◽  
Cell Fates ◽  
Anchor Cell

How do intercellular signals that pattern cell fates vary in evolution? During nematode vulva development, precursor cells acquire one of three fates in a pattern centered around the gonadal anchor cell. Non-vulval fates are at the periphery, outer and inner vulval fates are towards the center. In Caenorhabditis elegans, the three fates are specified around the same time by an induction by the anchor cell and lateral signaling between the vulva precursor cells. We find that, in three other nematode species (Panagrolaimus, Oscheius and Rhabditella spp.) spanning two families, the centered pattern is obtained by two temporally distinct gonadal inductions. The first induction specifies vulval fates; the second induction specifies the inner vulval fates in a subset of the precursors' daughters. This evolutionary change in the spatiotemporal connectivity of cell interactions allows centering of the pattern between two precursors in Panagrolaimus.

Timing and pattern of cell fate restrictions in the neural crest lineage

Development ◽  
1997 ◽  
Vol 124 (21) ◽  
pp. 4351-4359 ◽  
Author(s):  
P.D. Henion ◽  
J.A. Weston
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Neural Tube ◽  
Neural Crest Cell ◽  
Precursor Cells ◽  
Cell Fates ◽  
Distinct Cell ◽  
Ventral Pathway ◽  
Neural Crest Cell Migration

The trunk neural crest of vertebrate embryos is a transient collection of precursor cells present along the dorsal aspect of the neural tube. These cells migrate on two distinct pathways and give rise to specific derivatives in precise embryonic locations. One group of crest cells migrates early on a ventral pathway and generates neurons and glial cells. A later-dispersing group migrates laterally and gives rise to melanocytes in the skin. These observations raise the possibility that the appearance of distinct derivatives in different embryonic locations is a consequence of lineage restrictions specified before or soon after the onset of neural crest cell migration. To test this notion, we have assessed when and in what order distinct cell fates are specified during neural crest development. We determined the proportions of different types of precursor cells in cultured neural crest populations immediately after emergence from the neural tube and at intervals as development proceeds. We found that the initial neural crest population was a heterogeneous mixture of precursors almost half of which generated single-phenotype clones. Distinct neurogenic and melanogenic sublineages were also present in the outgrowth population almost immediately, but melanogenic precursors dispersed from the neural tube only after many neurogenic precursors had already done so. A discrete fate-restricted neuronal precursor population was distinguished before entirely separate fate-restricted melanocyte and glial precursor populations were present, and well before initial neuronal differentiation. Taken together, our results demonstrate that lineage-restricted subpopulations constitute a major portion of the initial neural crest population and that neural crest diversification occurs well before overt differentiation by the asynchronous restriction of distinct cell fates. Thus, the different morphogenetic and differentiative behavior of neural crest subsets in vivo may result from earlier cell fate-specification events that generate developmentally distinct subpopulations that respond differentially to environmental cues.

Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells

Development ◽  
1999 ◽  
Vol 126 (9) ◽  
pp. 1947-1956 ◽  
Author(s):  
V. Ambros
Keyword(s):  
Cell Cycle ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Precursor Cells ◽  
S Phase ◽  
Cycle Phase ◽  
Cell Fates ◽  
Cell Fate Decisions ◽  
Cycle Arrest ◽  
Cycle Dependent

In Caenorhabditis elegans, the fates of the six multipotent vulva precursor cells (VPCs) are specified by extracellular signals. One VPC expresses the primary (1 degrees) fate in response to a Ras-mediated inductive signal from the gonad. The two VPCs flanking the 1 degrees cell each express secondary (2 degrees) fates in response to lin-12-mediated lateral signaling. The remaining three VPCs each adopt the non-vulval tertiary (3 degrees) fate. Here I describe experiments examining how the selection of these vulval fates is affected by cell cycle arrest and cell cycle-restricted lin-12 activity. The results suggest that lin-12 participates in two developmental decisions separable by cell cycle phase: lin-12 must act prior to the end of VPC S phase to influence a 1 degrees versus 2 degrees cell fate choice, but must act after VPC S phase to influence a 3 degrees versus 2 degrees cell fate choice. Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells.

orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila

Development ◽  
1992 ◽  
Vol 115 (3) ◽  
pp. 801-811 ◽  
Author(s):  
E. Wieschaus ◽  
N. Perrimon ◽  
R. Finkelstein
Keyword(s):  
Pattern Formation ◽  
Gene Product ◽  
Nuclear Protein ◽  
Clonal Analysis ◽  
Precursor Cells ◽  
Cell Fates ◽  
Medial Region ◽  
Genital Discs ◽  
Lateral Structures ◽  
Embryonic Head

Lethal alleles of orthodenticle (= otd) cause abnormalities in the embryonic head that reflect an early role in anterior pattern formation. In addition, otd activity is required for the development of the larval and adult epidermis. Clonal analysis of both viable and lethal alleles shows that the adult requirement for otd is restricted to medial regions of certain discs. When otd activity is reduced or removed, some medial precursor cells produce bristles and cuticle characteristic of more lateral structures. Similar medial defects are observed in the larval epidermis of embryos homozygous for lethal otd alleles. Antibodies to otd recognize a nuclear protein found at high levels in the medial region of the eye antennal discs, the leg discs, the genital discs and along the ventral midline of the ventral epidermis of the embryo. These results suggest that the otd gene product is required to specify medial cell fates in both the larval and adult epidermis.

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

2009 ◽  
Vol 138 (3) ◽  
pp. 562-575
Author(s):  
Dan Han ◽  
Alana G. Lerner ◽  
Lieselotte Vande Walle ◽  
John-Paul Upton ◽  
Weihong Xu ◽  
...  
Keyword(s):  
Cell Fates ◽  
Kinase Activation
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