Development of FGF-Dependency in Human Embryonic Carcinoma Cells after Retinoic Acid-Induced Differentiation

1994 ◽  
Vol 161 (1) ◽  
pp. 141-153 ◽  
Author(s):  
Tuomo Alanko ◽  
Jukka Tienari ◽  
Eero Lehtonen ◽  
Olli Saksela
Keyword(s):  
Retinoic Acid ◽  
Carcinoma Cells ◽  
Induced Differentiation ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells

scholarly journals Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2

2019 ◽  
Vol 20 (9) ◽  
pp. 2071 ◽  
Author(s):  
Mengying Yu ◽  
Lei Zhang ◽  
Yingxiang Liu ◽  
Defu Liu ◽  
Zekun Guo
Keyword(s):  
Retinoic Acid ◽  
Cell Differentiation ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Embryonic Carcinoma ◽  
Extracellular Signal ◽  
Embryonic Carcinoma Cells ◽  
Embryonic Carcinoma Cell ◽  
Mediate Cell

Retinoic acid (RA) plays a key role in pluripotent cell differentiation. In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear. Here, we show that miR-485 is a positive regulator that targets α/β-hydrolase domain-containing protein 2 (Abhd2), which can result in Erk1/2 phosphorylation and triggers differentiation. RA up-regulates miR-485 and concurrently down-regulates Abhd2. We verified that Abhd2 is targeted by miR-485 and they both can influence the phosphorylation of Erk1/2. In summary, RA can mediate cell differentiation by phosphorylating Erk1/2 via miR-485 and Abhd2.

scholarly journals Disassociation of MAPK Activation and c-Fos Expression in F9 Embryonic Carcinoma Cells following Retinoic Acid-induced Endoderm Differentiation

2001 ◽  
Vol 276 (34) ◽  
pp. 32094-32100 ◽  
Author(s):  
Elizabeth R. Smith ◽  
Jennifer L. Smedberg ◽  
Malgorzata E. Rula ◽  
Thomas C. Hamilton ◽  
Xiang-Xi Xu
Keyword(s):  
Retinoic Acid ◽  
Carcinoma Cells ◽  
Mapk Activation ◽  
Endoderm Differentiation ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells ◽  
Fos Expression

scholarly journals SC1 inhibits the differentiation of F9 embryonic carcinoma cells induced by retinoic acid

2018 ◽  
Vol 50 (8) ◽  
pp. 793-799
Author(s):  
Yingxiang Liu ◽  
Xuexue Ren ◽  
Jie Ke ◽  
Yan Zhang ◽  
Qing Wei ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Carcinoma Cells ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells
Sign in / Sign up

Export Citation Format

Share Document