RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells

2013 ◽  
Vol 114 (9) ◽  
pp. 2007-2015 ◽  
Author(s):  
Yousra S. Malik ◽  
Muhammad A. Sheikh ◽  
Mingming Lai ◽  
Rangjuan Cao ◽  
Xiaojuan Zhu
Keyword(s):  
Cell Cycle ◽  
Retinoic Acid ◽  
Neuronal Differentiation ◽  
Ring Finger ◽  
Carcinoma Cells ◽  
Cell Cycle Exit ◽  
Ring Finger Protein ◽  
Embryonic Carcinoma ◽  
Finger Protein ◽  
Embryonic Carcinoma Cells

scholarly journals Sox6 overexpression causes cellular aggregation and the neuronal differentiation of P19 embryonic carcinoma cells in the absence of retinoic acid

FEBS Letters ◽  
2004 ◽  
Vol 560 (1-3) ◽  
pp. 192-198 ◽  
Author(s):  
Michiko Hamada-Kanazawa ◽  
Kyoko Ishikawa ◽  
Kaori Nomoto ◽  
Takako Uozumi ◽  
Yuichi Kawai ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neuronal Differentiation ◽  
Carcinoma Cells ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells ◽  
Cellular Aggregation

scholarly journals Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2

2019 ◽  
Vol 20 (9) ◽  
pp. 2071 ◽  
Author(s):  
Mengying Yu ◽  
Lei Zhang ◽  
Yingxiang Liu ◽  
Defu Liu ◽  
Zekun Guo
Keyword(s):  
Retinoic Acid ◽  
Cell Differentiation ◽  
Carcinoma Cell ◽  
Carcinoma Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Embryonic Carcinoma ◽  
Extracellular Signal ◽  
Embryonic Carcinoma Cells ◽  
Embryonic Carcinoma Cell ◽  
Mediate Cell

Retinoic acid (RA) plays a key role in pluripotent cell differentiation. In F9 embryonic carcinoma cells, RA can induce differentiation towards somatic lineages via the Ras-extracellular signal-regulated kinase (Ras/Erk) pathway, but the mechanism through which it induces the Erk1/2 phosphorylation is unclear. Here, we show that miR-485 is a positive regulator that targets α/β-hydrolase domain-containing protein 2 (Abhd2), which can result in Erk1/2 phosphorylation and triggers differentiation. RA up-regulates miR-485 and concurrently down-regulates Abhd2. We verified that Abhd2 is targeted by miR-485 and they both can influence the phosphorylation of Erk1/2. In summary, RA can mediate cell differentiation by phosphorylating Erk1/2 via miR-485 and Abhd2.

scholarly journals MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation

2002 ◽  
Vol 7 (8) ◽  
pp. 835-850 ◽  
Author(s):  
Takeshi Akasaka ◽  
Naomi Takahashi ◽  
Maki Suzuki ◽  
Haruhiko Koseki ◽  
Rolf Bodmer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ring Finger ◽  
Gene Products ◽  
Ring Finger Protein ◽  
Finger Protein ◽  
Cycle Dependent

scholarly journals E2F1 Mediates the Retinoic Acid-Induced Transcription of Tshz1 during Neuronal Differentiation in a Cell Division-Dependent Manner

2018 ◽  
Vol 38 (21) ◽  
Author(s):  
Jo Hae Park ◽  
Kunsoo Rhee
Keyword(s):  
Retinoic Acid ◽  
Cell Division ◽  
Neuronal Differentiation ◽  
Cellular Differentiation ◽  
Specific Region ◽  
Carcinoma Cells ◽  
Dependent Manner ◽  
Embryonic Carcinoma Cells ◽  
A Cell ◽  
Series Of Experiments

ABSTRACT The involvement of cell division in cellular differentiation has long been accepted. Cell division may be required not only for the expansion of a differentiated cell population but also for the execution of differentiation processes. Nonetheless, knowledge regarding how specific differentiation processes are controlled in a cell division-dependent manner is far from complete. Here, we determined the involvement of cell division in neuronal differentiation. We initially confirmed that cell division is an essential event for the neuronal differentiation of P19 embryonic carcinoma cells. We investigated the induction mechanisms of Tshz1, whose expression is induced by retinoic acid (RA) in a cell division-dependent manner. Promoter analysis of Tshz1 revealed a specific region required for RA-dependent transcription. A series of experiments was used to identify E2F1 as the induction factor for the RA-dependent transcription of Tshz1. We propose that E2F1 mediates neuronal differentiation in a cell division-dependent manner.

Bilobalide Induces Neuronal Differentiation of P19 Embryonic Carcinoma Cells via Activating Wnt/β-Catenin Pathway

2014 ◽  
Vol 34 (6) ◽  
pp. 913-923 ◽  
Author(s):  
Mei Liu ◽  
Jingjing Guo ◽  
Juan Wang ◽  
Luyong Zhang ◽  
Tao Pang ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Carcinoma Cells ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells

scholarly journals Disassociation of MAPK Activation and c-Fos Expression in F9 Embryonic Carcinoma Cells following Retinoic Acid-induced Endoderm Differentiation

2001 ◽  
Vol 276 (34) ◽  
pp. 32094-32100 ◽  
Author(s):  
Elizabeth R. Smith ◽  
Jennifer L. Smedberg ◽  
Malgorzata E. Rula ◽  
Thomas C. Hamilton ◽  
Xiang-Xi Xu
Keyword(s):  
Retinoic Acid ◽  
Carcinoma Cells ◽  
Mapk Activation ◽  
Endoderm Differentiation ◽  
Embryonic Carcinoma ◽  
Embryonic Carcinoma Cells ◽  
Fos Expression
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