REST4-Mediated Modulation of REST/NRSF-Silencing Function during BDNF Gene Promoter Activation

2002 ◽  
Vol 290 (1) ◽  
pp. 415-420 ◽  
Author(s):  
Akiko Tabuchi ◽  
Tomoko Yamada ◽  
Shoko Sasagawa ◽  
Yoshihisa Naruse ◽  
Nozomu Mori ◽  
...  
Keyword(s):  
Gene Promoter ◽  
Bdnf Gene ◽  
Promoter Activation

scholarly journals Regulation of the Expression of Heme Oxygenase-1: Signal Transduction, Gene Promoter Activation, and Beyond

2020 ◽  
Vol 32 (14) ◽  
pp. 1033-1044 ◽  
Author(s):  
María Victoria Medina ◽  
Daiana Sapochnik ◽  
Martín Garcia Solá ◽  
Omar Coso
Keyword(s):  
Signal Transduction ◽  
Heme Oxygenase ◽  
Gene Promoter ◽  
Heme Oxygenase 1 ◽  
Promoter Activation

scholarly journals Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69115 ◽  
Author(s):  
Ilse M. Beck ◽  
Zuzanna J. Drebert ◽  
Ruben Hoya-Arias ◽  
Ali A. Bahar ◽  
Michael Devos ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Glucocorticoid Receptor ◽  
Gene Promoter ◽  
Hsp70 Gene ◽  
Promoter Activation ◽  
Compound A ◽  
Receptor Modulator ◽  
Heat Shock Protein Hsp70

Interleukin-15 induces IL-12 receptor β1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling

Blood ◽  
2005 ◽  
Vol 105 (2) ◽  
pp. 711-720 ◽  
Author(s):  
Tipayaratn Musikacharoen ◽  
Asako Oguma ◽  
Yasunobu Yoshikai ◽  
Norika Chiba ◽  
Akio Masuda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chromatin Remodeling ◽  
Transcriptional Activation ◽  
Transcriptional Start Site ◽  
Regulatory Region ◽  
Gene Promoter ◽  
Interferon Γ ◽  
Interleukin 12 ◽  
Promoter Activation ◽  
Ifn Γ

AbstractInterleukin-12 receptor β1 (IL12RB1) is expressed on a variety of immune cells, including T and natural killer (NK) cells and macrophages, and is involved in innate and adaptive immune responses. Levels of IL12RB1 mRNA are dynamically regulated by various cytokines, including interferon-γ (IFN-γ) and IL-15. To reveal the regulatory mechanisms governing IL12RB1 gene expression, we analyzed the transcriptional regulatory region of the mouse IL12RB1 gene. Promoter analyses in a mouse macrophage cell line, RAW264.7, revealed that the 2508-bp region upstream of the transcriptional start site is sufficient for the full transcriptional activation of the IL12RB1 gene by IFN-γ or IL-15. Analyses of the deletion mutants revealed critical roles of IRE/ISRE and ETS/PU.1 elements, to which IRF3 and PU.1, respectively, bound. Notably, chromatin immunoprecipitation (ChIP) assays revealed IL-15 rapidly induced histone H3 acetylation at the IL12RB1 promoter. Consistently, IL-15, as a histone deacetylase inhibitor, synergistically enhanced IL12RB1 gene expression and promoter activation by IFN-γ through increased protein binding to ETS/PU.1 and IRE/ISRE sites. Additionally, IL12RB1 promoter activation by IFN-γ was enhanced by the coexpression of a coactivator protein, CBP. Thus, IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-γ through the recruitment of PU.1 and IRF3.

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