scholarly journals Regulation of the Expression of Heme Oxygenase-1: Signal Transduction, Gene Promoter Activation, and Beyond

2020 ◽  
Vol 32 (14) ◽  
pp. 1033-1044 ◽  
Author(s):  
María Victoria Medina ◽  
Daiana Sapochnik ◽  
Martín Garcia Solá ◽  
Omar Coso
Keyword(s):  
Signal Transduction ◽  
Heme Oxygenase ◽  
Gene Promoter ◽  
Heme Oxygenase 1 ◽  
Promoter Activation

scholarly journals Microsatellite polymorphism in the heme oxygenase-1 gene promoter is not associated with alcoholic liver disease severity

Hepatology ◽  
2013 ◽  
Vol 59 (1) ◽  
pp. 352-353 ◽  
Author(s):  
Anne Lemaire ◽  
Eric Trépo ◽  
Romy Ouziel ◽  
Thierry Gustot ◽  
Christophe Moreno ◽  
...  
Keyword(s):  
Liver Disease ◽  
Disease Severity ◽  
Heme Oxygenase ◽  
Alcoholic Liver Disease ◽  
Gene Promoter ◽  
Microsatellite Polymorphism ◽  
Heme Oxygenase 1

scholarly journals Regulation of human heme oxygenase-1 gene expression under thermal stress

Blood ◽  
1996 ◽  
Vol 87 (12) ◽  
pp. 5074-5084 ◽  
Author(s):  
S Okinaga ◽  
K Takahashi ◽  
K Takeda ◽  
M Yoshizawa ◽  
H Fujita ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thermal Stress ◽  
Heat Shock ◽  
Transient Expression ◽  
Reporter Gene ◽  
Heme Oxygenase ◽  
Gene Promoter ◽  
Heme Oxygenase 1 ◽  
Heat Shock Element ◽  
Hsp70 Mrna

Heme oxygenase-1 is an essential enzyme in heme catabolism, and its human gene promoter contains a putative heat shock element (HHO-HSE). This study was designed to analyze the regulation of human heme oxygenase-1 gene expression under thermal stress. The amounts of heme oxygenase-1 protein were not increased by heat shock (incubation at 42 degrees C) in human alveolar macrophages and in a human erythroblastic cell line, YN-1–0-A, whereas heat shock protein 70 (HSP70) was noticeably induced. However, heat shock factor does bind in vitro to HHO-HSE and the synthetic HHO-HSE by itself is sufficient to confer the increase in the transient expression of a reporter gene upon heat shock. The deletion of the sequence, located downstream from HHO-HSE, resulted in the activation of a reporter gene by heat shock. These results suggest that HHO-HSE is potentially functional but is repressed in vivo. Interestingly, heat shock abolished the remarkable increase in the levels of heme oxygenase-1 mRNA in YN-1–0-A cells treated with hemin or cadmium, in which HSP70 mRNA was noticeably induced. Furthermore, transient expression assays showed that heat shock inhibits the cadmium-mediated activation of the heme oxygenase-1 promoter, whereas the HSP70 gene promoter was activated upon heat shock. Such regulation of heme oxygenase-1 under thermal stress may be of physiologic significance in erythroid cells.

Association of heme oxygenase-1 gene promoter polymorphism and blood pressure in an Iranian population

2014 ◽  
Vol 44 (9) ◽  
pp. 931-932 ◽  
Author(s):  
F. Haghdoost ◽  
S. H. Javanmard ◽  
K. Keyhanian ◽  
A. A. Samety ◽  
P. Loghmani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heme Oxygenase ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Iranian Population ◽  
Heme Oxygenase 1 ◽  
Gene Promoter Polymorphism

scholarly journals Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter

2015 ◽  
pp. 6379 ◽  
Author(s):  
Jia-Qiang Zhang ◽  
Jian-Qing Zhang ◽  
Li-Zhou Fang ◽  
Ling Liu ◽  
Wei-Ping Fu ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Gene Promoter ◽  
Microsatellite Polymorphism ◽  
Heme Oxygenase 1 ◽  
Copd Patients

Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism is Associated with Restenosis after Percutaneous Transluminal Angioplasty

2001 ◽  
Vol 8 (5) ◽  
pp. 433-440 ◽  
Author(s):  
Markus Exner ◽  
Martin Schillinger ◽  
Erich Minar ◽  
Wolfgang Mlekusch ◽  
Gerald Schlerka ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Percutaneous Transluminal Angioplasty ◽  
Protective Factor ◽  
Ankle Brachial Index ◽  
Balloon Dilation ◽  
Gene Promoter ◽  
Transluminal Angioplasty ◽  
Heme Oxygenase 1 ◽  
Dinucleotide Repeats ◽  
Percutaneous Transluminal

Purpose: To determine if an association exists between postdilation restenosis and heme oxygenase-1 (HO-1), which is induced by balloon injury and inhibits neointimal formation through the action of endogenous carbon monoxide. A dinucleotide repeat in the promoter region of the HO-1 gene shows a length polymorphism that modulates the level of gene transcription. Methods: This cohort study included 96 consecutive patients (64 men; median age 69 years, interquartile range 60–75) who underwent successful balloon dilation in the femoropopliteal segment. Six-month patency was evaluated using oscillography, ankle-brachial index, and duplex sonography. The association of patency and the length of (GT) repeats in the HO-1 gene promoter was assessed in univariate and multivariate analyses. Results: Restenosis was found in 23 (24%) patients within the first 6 months. Patients with short (<25 GT) dinucleotide repeats in the HO-1 gene promoter on either allele had restenosis significantly less often than patients with longer (≥25 GT) dinucleotide repeats (p = 0.01). Multivariate analysis revealed a significantly reduced risk for restenosis in these patients compared to patients without the short allele (odds ratio 0.2, 95% CI 0.06 to 0.70, p = 0.007). Conclusions: Genetic risk factors for restenosis after percutaneous transluminal angioplasty have not been investigated. In this patient population, short repeat alleles of the heme oxygenase-1 gene promoter polymorphism were associated with reduced postdilation restenosis at 6 months. Upregulation of HO-1 may be an important protective factor after balloon angioplasty by inhibition of vascular smooth muscle cell proliferation.

scholarly journals Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients

2010 ◽  
Vol 17 (1) ◽  
pp. 12 ◽  
Author(s):  
Chyi-Huey Bai ◽  
Jiunn-Rong Chen ◽  
Hou-Chang Chiu ◽  
Chia-Chi Chou ◽  
Lee-Young Chau ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Protective Effect ◽  
Heme Oxygenase ◽  
Gene Promoter ◽  
Heme Oxygenase 1 ◽  
Repeat Polymorphism
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