Effect of Superoxide Dismutase Mimics on Radical Adduct Formation during the Reaction between Peroxynitrite and Thiols—An ESR-Spin Trapping Study

1996 ◽  
Vol 330 (1) ◽  
pp. 115-124 ◽  
Author(s):  
Hakim Karoui ◽  
Neil Hogg ◽  
Joy Joseph ◽  
B. Kalyanaraman
Keyword(s):  
Superoxide Dismutase ◽  
Spin Trapping ◽  
Adduct Formation ◽  
Esr Spin Trapping ◽  
Radical Adduct ◽  
Superoxide Dismutase Mimics

scholarly journals Superoxide dismutase(SOD) activity measured by ESR-spin trapping method in canine vocal cords.

1991 ◽  
Vol 94 (5) ◽  
pp. 712-715
Author(s):  
TADASHI FUJIOKA ◽  
HIROKI ITOH ◽  
OHRU TSUZUKI ◽  
YASUO TANAKA
Keyword(s):  
Superoxide Dismutase ◽  
Spin Trapping ◽  
Vocal Cords ◽  
Sod Activity ◽  
Esr Spin Trapping ◽  
Trapping Method

scholarly journals Formation of peroxide- and globin-derived radicals from the reaction of methaemoglobin and metmyoglobin with t-butyl hydroperoxide: an ESR spin-trapping investigation

1997 ◽  
Vol 322 (2) ◽  
pp. 633-639 ◽  
Author(s):  
Jolanda Van der ZEE
Keyword(s):  
Spin Trap ◽  
Hydrogen Abstraction ◽  
Spin Trapping ◽  
Tyrosyl Radical ◽  
Alkoxyl Radical ◽  
Butyl Hydroperoxide ◽  
Heterolytic Cleavage ◽  
Esr Spin Trapping ◽  
Radical Adduct ◽  
Protein Radicals

The reaction of human methaemoglobin and horse metmyoglobin with t-butyl hydroperoxide (t-BuOOH) was investigated with the ESR spin-trapping technique. With the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) the formation of peroxyl, alkoxyl and methyl radicals derived from t-BuOOH could be detected. The relative contributions of these radicals were determined at various DMPO concentrations by computer simulation. From these data it could be concluded that the alkoxyl radical was the initial radical produced, which indicates that the hydroperoxide is cleaved homolytically. Further investigations, with the nitroso spin trap 2-methyl-2-nitrosopropane (MNP), showed the formation of globin-centred radicals. Non-specific proteolysis of the MNP adducts revealed isotropic three-line spectra, which means that the radical adducts were centred on a tertiary carbon with no bonds to a hydrogen or nitrogen. Comparison with MNP adducts of several amino acids indicated that in methaemoglobin the radical adduct was most probably located on a valine residue. With metmyoglobin the same adduct was obtained, whereas an additional adduct could be assigned to a tyrosyl radical. These protein radicals most probably resulted from hydrogen abstraction by the metal–oxo species, formed by heterolytic cleavage of the hydroperoxide. These results therefore show that homolytic cleavage of the hydroperoxide leads to the formation of peroxide-derived radicals, whereas concurrent heterolytic cleavage results in protein-derived radicals.

Modification of inflammatory response to implanted biomedical materialsin vivo by surface bound superoxide dismutase mimics

2000 ◽  
Vol 51 (4) ◽  
pp. 549-560 ◽  
Author(s):  
Kishore Udipi ◽  
Richard L. Ornberg ◽  
K. Bruce Thurmond ◽  
Steven L. Settle ◽  
Denis Forster ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Inflammatory Response ◽  
Superoxide Dismutase Mimics

scholarly journals Synthesis of Polymeric Reconstituted Hemoglobins as Superoxide Dismutase Mimics Designed for Long-term Circulation Maintenance

2005 ◽  
Vol 54 (7) ◽  
pp. 413-418 ◽  
Author(s):  
Makoto YUASA ◽  
Kenichi OYAIZU ◽  
Takamitsu HAYASHI ◽  
Aritomo YAMAGUCHI
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase Mimics

scholarly journals Superoxide dismutase mimics improves semen quality during chilled preservation of rabbit spermatozoa

2019 ◽  
Vol 221 ◽  
pp. 70-76
Author(s):  
Osama Galal Sakr ◽  
Ahmed Gad ◽  
María Rodríguez ◽  
Pilar García Rebollar ◽  
Pilar Millán
Keyword(s):  
Superoxide Dismutase ◽  
Semen Quality ◽  
Superoxide Dismutase Mimics ◽  
Rabbit Spermatozoa

ChemInform Abstract: PHOTOCATALYTIC SYSTEMS. XXXIII. PHOTOREACTIONS OF OCTACYANOMOLYBDATE(V) IN NONAQUEOUS SOLUTION STUDIED BY ESR SPIN TRAPPING

1980 ◽  
Vol 11 (6) ◽  
Author(s):  
D. REHOREK ◽  
J. SALVETTER ◽  
A. HANTSCHMANN ◽  
H. HENNIG ◽  
Z. STASICKA ◽  
...  
Keyword(s):  
Spin Trapping ◽  
Nonaqueous Solution ◽  
Esr Spin Trapping
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