CyDEPMPOs: A class of stable cyclic DEPMPO derivatives with improved properties as mechanistic markers of stereoselective hydroxyl radical adduct formation in biological systems

2011 ◽  
Vol 19 (7) ◽  
pp. 2218-2230 ◽  
Author(s):  
Gaëlle Gosset ◽  
Jean-Louis Clément ◽  
Marcel Culcasi ◽  
Antal Rockenbauer ◽  
Sylvia Pietri
Keyword(s):  
Hydroxyl Radical ◽  
Biological Systems ◽  
Adduct Formation ◽  
Radical Adduct

Phenyl N-Tert-Butyl Nitrone Forms Nitric Oxide as a Result of Its Fe(Iii)-Catalyzed Hydrolysis Or Hydroxyl Radical Adduct Formation

1995 ◽  
Vol 23 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Walee Chamulitrat ◽  
Carol E. Parker ◽  
Kenneth B. Tomer ◽  
Ronald P. Mason
Keyword(s):  
Nitric Oxide ◽  
Hydroxyl Radical ◽  
Adduct Formation ◽  
Tert Butyl ◽  
Radical Adduct

Hydroxyl Radical Reaction with trans-Resveratrol: Initial Carbon Radical Adduct Formation Followed by Rearrangement to Phenoxyl Radical

2012 ◽  
Vol 116 (24) ◽  
pp. 7154-7161 ◽  
Author(s):  
Dan-Dan Li ◽  
Rui-Min Han ◽  
Ran Liang ◽  
Chang-Hui Chen ◽  
Wenzhen Lai ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Radical Reaction ◽  
Phenoxyl Radical ◽  
Adduct Formation ◽  
Initial Carbon ◽  
Radical Adduct

scholarly journals Comparative Analysis of Radical Adduct Formation (RAF) Products and Antioxidant Pathways between Myricetin-3-O-Galactoside and Myricetin Aglycone

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2769 ◽  
Author(s):  
Xican Li ◽  
Xiaojian Ouyang ◽  
Minshi Liang ◽  
Dongfeng Chen
Keyword(s):  
Antioxidative Activity ◽  
Biological Process ◽  
Ultra Performance Liquid Chromatography ◽  
Adduct Formation ◽  
Chain Reaction ◽  
Radical Adduct ◽  
Ic50 Values ◽  
The Difference ◽  
A Chain ◽  
Inhibition Analysis

The biological process, 3-O-galactosylation, is important in plant cells. To understand the mechanism of the reduction of flavonol antioxidative activity by 3-O-galactosylation, myricetin-3-O-galactoside (M3OGa) and myricetin aglycone were each incubated with 2 mol α,α-diphenyl-β-picrylhydrazyl radical (DPPH•) and subsequently comparatively analyzed for radical adduct formation (RAF) products using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS) technology. The analyses revealed that M3OGa afforded an M3OGa–DPPH adduct (m/z 873.1573) and an M3OGa–M3OGa dimer (m/z 958.1620). Similarly, myricetin yielded a myricetin–DPPH adduct (m/z 711.1039) and a myricetin–myricetin dimer (m/z 634.0544). Subsequently, M3OGa and myricetin were compared using three redox-dependent antioxidant analyses, including DPPH•-trapping analysis, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•)-trapping analysis, and •O2 inhibition analysis. In the three analyses, M3OGa always possessed higher IC50 values than those of myricetin. Conclusively, M3OGa and its myricetin aglycone could trap the free radical via a chain reaction comprising of a propagation step and a termination step. At the propagation step, both M3OGa and myricetin could trap radicals through redox-dependent antioxidant pathways. The 3-O-galactosylation process, however, could limit these pathways; thus, M3OGa is an inferior antioxidant compared to its myricetin aglycone. Nevertheless, 3-O-galactosylation has a negligible effect on the termination step. This 3-O-galactosylation effect has provided novel evidence that the difference in the antioxidative activities of phytophenols exists at the propagation step rather than the termination step.

Fast repair of dAMP hydroxyl radical adduct by verbascoside via electron transfer

1999 ◽  
Vol 42 (6) ◽  
pp. 621-627 ◽  
Author(s):  
Yimin Shi ◽  
Wenfeng Wang ◽  
Yanping Shi ◽  
Zhongjian Jia ◽  
Side Yao ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Hydroxyl Radical ◽  
Radical Adduct ◽  
Fast Repair

Synthesis of creatol, a hydroxyl radical adduct of creatinine and its increase by puromycin aminonucleoside in isolated rat hepatocytes

1998 ◽  
Vol 29 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Kazumasa Aoyagi ◽  
Kayo Akiyama ◽  
Yutaka Kuzure ◽  
Katsumi Takemura ◽  
Sohji Nagase ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Rat Hepatocytes ◽  
Puromycin Aminonucleoside ◽  
Isolated Rat Hepatocytes ◽  
Radical Adduct ◽  
Isolated Rat
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