scholarly journals P17.07: What is marker that will be used for first trimester screening of open spina bifida?

2012 ◽  
Vol 40 (S1) ◽  
pp. 237-238
Author(s):  
S. Buyukkurt ◽  
U. Kucukgoz ◽  
Gulec ◽  
R. Melekoglu ◽  
C. Evruke ◽  
...  
Keyword(s):  
Spina Bifida ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Open Spina Bifida

scholarly journals A Case of Enlarged Intracranial Translucency in a Fetus with Blake’s Pouch Cyst

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Ambra Iuculano ◽  
Maria Angelica Zoppi ◽  
Rosa Maria Ibba ◽  
Giovanni Monni
Keyword(s):  
Spina Bifida ◽  
First Trimester ◽  
First Trimester Screening ◽  
Intracranial Translucency ◽  
Trimester Screening ◽  
Open Spina Bifida

The intracranial translucency (IT) is a recently introduced marker of open spina bifida (OSB). In this study, we describe a case of a fetus affected by Blake’s pouch cyst which showed alterations of BS/BSOB ratio at the first trimester screening.

Detection of Spina Bifida by First Trimester Screening – Results of the Prospective Multicenter Berlin IT-Study

2015 ◽  
Vol 38 (02) ◽  
pp. 151-157 ◽  
Author(s):  
Frank Chen ◽  
Janine Gerhardt ◽  
Michael Entezami ◽  
Rabih Chaoui ◽  
Wolfgang Henrich
Keyword(s):  
Spina Bifida ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening

Screening for Open Spina Bifida in a Routine Clinical Setting at the First-Trimester Scan: A Prospective Multicentre Cohort Study

2021 ◽  
pp. 1-7
Author(s):  
Johanna Tiechl ◽  
Samira Abdel Azim ◽  
Katharina Leitner ◽  
Astrid Berger ◽  
Irene Mutz-Dehbalaie ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Sensitivity And Specificity ◽  
First Trimester ◽  
Outcome Data ◽  
Prospective Multicentre Study ◽  
Multicentre Cohort Study ◽  
Routine Clinical Setting ◽  
Trimester Screening ◽  
Open Spina Bifida ◽  
Multicentre Cohort

<b><i>Objective:</i></b> The aim of this study was to investigate the performance of screening for open spina bifida (OSB) integrated into the routine first-trimester screening. <b><i>Method:</i></b> This is a prospective multicentre study of 4,755 women undergoing first-trimester ultrasound scans over a 4-year period. Measurements of the brainstem (BS) diameter and brainstem-to-occipital-bone (BSOB) distance were performed. The cisterna magna (CM) was measured in the tilted axial view. <b><i>Results:</i></b> Pregnancy outcome data were available for 4,658 fetuses included in this study. There were 5 fetuses with OSB, and in all of them, the BS/BSOB ratio and the CM measurements were abnormal. The sensitivity and specificity of a BS/BSOB ratio &#x3e;1 were 100%. The sensitivity of a CM width &#x3c;5th centile was 100%, and the specificity was 95.1%. In 4.6% of cases, the BS/BSOB ratio was between the 95th percentile and 1. In 87.1% of these cases, the CM was normal, and 12.9% had a CM below the 5th percentile. <b><i>Conclusion:</i></b> Screening for OSB is feasible in routine first-trimester scans. The BS/BSOB ratio shows a very good sensitivity and specificity. In cases with near-normal values for the BS/BSOB ratio, the CM width might be helpful for further assessment.

Trends in early prenatal screening for chromosomal abnormalities and congenital malformations in Russia in 2018

2020 ◽  
pp. 76-78
Author(s):  
Е.А. Калашникова ◽  
Е.Н. Андреева ◽  
П.А. Голошубов ◽  
Н.О. Одегова ◽  
Е.В. Юдина ◽  
...  
Keyword(s):  
Reference Values ◽  
Congenital Malformations ◽  
Prenatal Screening ◽  
Chromosomal Abnormalities ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Overall Effectiveness ◽  
Regions Of Russia

В ходе анализа результатов раннего пренатального скрининга (РПС) в России за 2018 г. (Аудит-2019) дана оценка качества мероприятий, общей эффективности и тенденций развития системы РПС в субъектах РФ посредством сравнения рассчитанных основных организационных, методологических и интегральных показателей с международными референтными значениями. In the course of analyzing the results of early prenatal combined first-trimester screening (FTS) in Russia for 2018 (Audit-2019) the assessment of the quality of measures, the overall effectiveness and trends in the development of the FTS system in the regions of Russia. They are presented by comparing the calculated main organizational, methodological and integral indicators with international reference values.

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