Distribution, metabolism, and fetal uptake of pentavalent arsenic in pregnant mice following oral or intraperitoneal administration

Teratology ◽  
1987 ◽  
Vol 35 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Ronald D. Hood ◽  
Ginger C. Vedel-Macrander ◽  
Michael J. Zaworotko ◽  
Fred M. Tatum ◽  
Robert G. Meeks
Keyword(s):  
Intraperitoneal Administration ◽  
Pentavalent Arsenic ◽  
Pregnant Mice ◽  
Fetal Uptake

scholarly journals Whole-body retention and fetal uptake of 65Zn in pregnant mice fed a Zn-deficient diet.

1995 ◽  
Vol 36 (3) ◽  
pp. 196-202 ◽  
Author(s):  
NAONORI MATSUSAKA ◽  
HIDEKI SAKAMOTO ◽  
ITARU SATO ◽  
KUNIHIRO SHINAGAWA ◽  
HARUO KOBAYASHI ◽  
...  
Keyword(s):  
Whole Body ◽  
Deficient Diet ◽  
Body Retention ◽  
Pregnant Mice ◽  
Fetal Uptake

RELATIONSHIP BETWEEN OESTROGEN, PROSTAGLANDIN F2α AND HISTAMINE IN DELAYED IMPLANTATION IN THE MOUSE

1976 ◽  
Vol 81 (4) ◽  
pp. 801-807 ◽  
Author(s):  
S. K. Saksena ◽  
I. F. Lau ◽  
M. C. Chang
Keyword(s):  
Single Injection ◽  
Intraperitoneal Administration ◽  
Cell Formation ◽  
Prostaglandin F2α ◽  
Decidual Cell ◽  
Mouse Uterus ◽  
Subcutaneous Injections ◽  
Ovariectomized Mice ◽  
Complete Reversal ◽  
Pregnant Mice

ABSTRACT Treatment of pregnant mice ovaricctomized on day 3 (23.00-2330 h) with progesterone (1 mg/day/mouse, from day 4 through 11 post coitum (p.c.)) and oestrogen (single injection of 0.05 αg on day 8 p. c.) induced implantation in all the animals. Implantation was inhibited in animals following three subcutaneous injections of indomethacin given on the morning and afternoon of day 8 and the morning of day 9 p. c. A single injection of histamine on day 8 p. c. partially compensated the effect of indomethacin. A complete reversal of the antifertility effect of indomethacin was achieved following intraperitoneal administration of histamine (2 αg at noon of day 8 p. c.) and PGF2α (20 μg on the morning and afternoon of day 8 p. c.). This study suggests that in the mouse uterus indomethacin impairs the physiological changes which are required for the decidual cell formation and implantation. It is likely that an injection of oestradiol in the progesterone treated ovariectomized mice triggers the release of PGF2α and histamine and that these compounds are involved in the chain of events leading to implantation of the blastocysts.

Clinical and Scintigraphic Findings in Radiation Myositis Complicating the Intraperitoneal Administration of 198Au

1965 ◽  
Vol 05 (02) ◽  
pp. 188-196
Author(s):  
J. Němec ◽  
J. Kubalt ◽  
S. Vohnout ◽  
J. Schubert ◽  
J. Sudek ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Ascitic Fluid ◽  
Saline Solution ◽  
Intraperitoneal Administration ◽  
Clinical Findings ◽  
Safety Measures ◽  
Muscle Necrosis

SummaryPraeperitoneal administration of colloidal 198Au complicating the treatment of anascitic ovarian cancer is reported. Typical scintiscans and various clinical findings of muscle necrosis and radiation myositis are described. Administration of larger amount of saline solution preceding the radiogold instillation controlled by simultaneous scintiscanning are suggested as safety measures in patients when no ascitic fluid is present.

Experimental Intraperitoneal Administration of Cisplatin-activated Carbon for Rat Ovarian Adenocarcinomas.

1996 ◽  
Vol 43 (1) ◽  
pp. 33-39
Author(s):  
TORU SUGIYAMA ◽  
TAKASHI NISHIDA ◽  
SEISUKE KUMAGAI ◽  
KIMIO USHIJIMA ◽  
ATSUHIKO SHINAGAWA ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Intraperitoneal Administration ◽  
Ovarian Adenocarcinomas

TERATOGENIK EKSTRAK ETANOL UWI BANGGAI UNGU (Dioscorea alata L.) PADA MENCIT BETINA (Mus musculus)

2020 ◽  
Vol 5 (2) ◽  
pp. 309-318
Author(s):  
Ihwan Ihwan ◽  
◽  
Rahmatia Rahmatia ◽  
Khildah Khaerati ◽  
Keyword(s):  
Treatment Group ◽  
Embryo Development ◽  
Mus Musculus ◽  
Birth Defect ◽  
Abnormal Development ◽  
Dioscorea Alata ◽  
Treatment Groups ◽  
Study Results ◽  
Pregnant Mice ◽  
Ethanol Extracts

Teratogenic is an abnormal development on embryo and is the cause of congenital defect or birth defect. This study aims to determine the effect of the addition of Dioscorea alata L. ethanol extracts to the embryo development on pregnant mice whose given orally to 24 mice which divided to 4 treatment groups, they are the normal group (NG) with NaCMC 0.5%; 28 mg/KgBB treatment group; 35 mg/KgBB; 42 mg/Kg BB. The addition of Dioscorea alata L ethanol extracts was done on the sixth day until the 15th day of pregnancy. On the 18th day of pregnancy, Laparaktomi was done to the pregnant mice and the embryo was taken out of the uterus. The observation was done to the fetus numbers, weight weighing of the fetus's body, dan length measurement of the fetus's body. Another observation is the observation of the external organ defect of the embryo. The study results that the addition of Dioscorea alata L ethanol extracts with various doses have no significant effect (P>0.5) to the mice external fetus development. On the examination of the fetus, we can conclude that Dioscorea alata L ethanol extracts don’t give any effect that may cause the defect of the fetus’ external organ.

ACUTE TOXICITY OF CERIUM DIOXIDE NANOPARTICLES

2019 ◽  
pp. 56-62
Author(s):  
N. V. Khodykina ◽  
L. P. Tochilkina ◽  
O. N. Novikova ◽  
M. S. Sroslov ◽  
A. Ya. Pocheptsov ◽  
...  
Keyword(s):  
Toxic Effect ◽  
Cerium Dioxide ◽  
Intraperitoneal Administration ◽  
Body Weight Loss ◽  
The Body ◽  
Prooxidant Effect ◽  
High Exposure ◽  
Abdominal Organs ◽  
Metabolic Imbalance ◽  
Hematological Changes

The resorptive effects of 0.01 M cerium nanodioxide sol upon single intraperitoneal administration to rats have been studied. The acute exposure to nanoparticles was found to have a dose-dependent general toxic effect on the body (weight loss, inflammatory changes in the abdominal organs, modification of individual behavior, hematological changes, metabolic imbalance), which develops on the background of POL activation. The prooxidant effect of cerium dioxide nanoparticles is demonstratively manifested at relatively high exposure levels (80–8 mg / kg). The threshold dose for the general toxic effect (Limch integr) is equal to 0.8 mg / kg.

ROLE OF THE STROMAL CELLULAR COMPONENT IN COMPENSATORY PROCESSES IN DIFFUSE LIVER DAMAGE

2018 ◽  
pp. 32-37 ◽  
Author(s):  
Z. A. Shafigullina ◽  
S. Yu. Medvedeva ◽  
I. G. Danilova
Keyword(s):  
Toxic Hepatitis ◽  
Intraperitoneal Administration ◽  
Sharp Decrease ◽  
Cellular Component ◽  
Ki 67 ◽  
Sinusoidal Cells ◽  
Toxic Damage ◽  
Stromal Component ◽  
Regeneration Processes

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

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