scholarly journals UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway

Stem Cells ◽  
2017 ◽  
Vol 35 (11) ◽  
pp. 2267-2279 ◽  
Author(s):  
Jiahui Mao ◽  
Zhaofeng Liang ◽  
Bin Zhang ◽  
Huan Yang ◽  
Xia Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cancer Progression ◽  
Mouse Bone Marrow ◽  
Deficient Mouse ◽  
Gastric Cancer Progression

scholarly journals USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33329-33342 ◽  
Author(s):  
Yue Ma ◽  
Hua-Lin Fu ◽  
Zhen Wang ◽  
Hai Huang ◽  
Jian Ni ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Progression ◽  
Gastric Cancer Progression

scholarly journals Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

2018 ◽  
Author(s):  
Guozong Wang ◽  
Zhentao Man ◽  
Nianping Zhang ◽  
Hua Xin ◽  
Yi Li ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cyclic Peptides ◽  
Mouse Bone Marrow ◽  
Cell Affinity

scholarly journals Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli

2020 ◽  
Vol 21 (22) ◽  
pp. 8561
Author(s):  
Donghyun Nam ◽  
Aran Park ◽  
Maria Jose Dubon ◽  
Jinyeong Yu ◽  
Wootak Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mouse Bone Marrow ◽  
Functional Interactions ◽  
Combination Treatments

Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or interact with each other during BM-MSC mobilization. This study used mouse bone marrow-derived mesenchymal stem cell-like ST2 cells and human BM-MSCs to evaluate whether SP, TGF-β, and SDF-1 mutually regulate their respective effects on the mobilization of BM-MSCs. SP pretreatment of ST2 and BM-MSCs impaired their response to TGF-β while the introduction of SP receptor antagonist restored the mobilization of ST2 and BM-MSCs in response to TGF-β. TGF-β pretreatment did not affect the migration of ST2 and BM-MSCs in response to SP, but downregulated their migration in response to SDF-1. SP pretreatment modulated the activation of TGF-β noncanonical pathways in ST2 cells and BM-MSCs, but not canonical pathways. These results suggest that the migration of mesenchymal stem cells is regulated by complex functional interactions between SP, TGF-β, and SDF-1. Thus, understanding the complex functional interactions of these chemotactic stimuli would contribute to ensuring the development of safe and effective combination treatments for the mobilization of BM-MSCs.

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