Mouse bone marrow-derived mesenchymal stem cell response to nanostructured titanium substrates produced by high-pressure torsion

2012 ◽  
Vol 45 (2) ◽  
pp. 619-627 ◽  
Author(s):  
Mana Novin ◽  
Shahab Faghihi
Keyword(s):  
Bone Marrow ◽  
High Pressure ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Response ◽  
High Pressure Torsion ◽  
Mouse Bone Marrow ◽  
Nanostructured Titanium ◽  
Titanium Substrates

Investigation of magnesium–zinc–calcium alloys and bone marrow derived mesenchymal stem cell response in direct culture

2015 ◽  
Vol 12 ◽  
pp. 298-321 ◽  
Author(s):  
Aaron F. Cipriano ◽  
Amy Sallee ◽  
Ren-Guo Guan ◽  
Zhan-Yong Zhao ◽  
Myla Tayoba ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Response

Bone marrow mesenchymal stem cell response to nano-structured oxidized and turned titanium surfaces

2011 ◽  
Vol 23 (6) ◽  
pp. 733-740 ◽  
Author(s):  
Marco Annunziata ◽  
Adriana Oliva ◽  
Antonietta Buosciolo ◽  
Michele Giordano ◽  
Agostino Guida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Response ◽  
Titanium Surfaces

scholarly journals Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

2018 ◽  
Author(s):  
Guozong Wang ◽  
Zhentao Man ◽  
Nianping Zhang ◽  
Hua Xin ◽  
Yi Li ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cyclic Peptides ◽  
Mouse Bone Marrow ◽  
Cell Affinity

scholarly journals Coordinated Regulation of Mesenchymal Stem Cell Migration by Various Chemotactic Stimuli

2020 ◽  
Vol 21 (22) ◽  
pp. 8561
Author(s):  
Donghyun Nam ◽  
Aran Park ◽  
Maria Jose Dubon ◽  
Jinyeong Yu ◽  
Wootak Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mouse Bone Marrow ◽  
Functional Interactions ◽  
Combination Treatments

Endogenous bone marrow-derived mesenchymal stem cells are mobilized to peripheral blood and injured tissues in response to changes in the expression of various growth factors and cytokines in the injured tissues, including substance P (SP), transforming growth factor-beta (TGF-β), and stromal cell-derived factor-1 (SDF-1). SP, TGF-β, and SDF-1 are all known to induce the migration of bone marrow-derived mesenchymal stem cells (BM-MSCs). However, it is not yet clear how these stimuli influence or interact with each other during BM-MSC mobilization. This study used mouse bone marrow-derived mesenchymal stem cell-like ST2 cells and human BM-MSCs to evaluate whether SP, TGF-β, and SDF-1 mutually regulate their respective effects on the mobilization of BM-MSCs. SP pretreatment of ST2 and BM-MSCs impaired their response to TGF-β while the introduction of SP receptor antagonist restored the mobilization of ST2 and BM-MSCs in response to TGF-β. TGF-β pretreatment did not affect the migration of ST2 and BM-MSCs in response to SP, but downregulated their migration in response to SDF-1. SP pretreatment modulated the activation of TGF-β noncanonical pathways in ST2 cells and BM-MSCs, but not canonical pathways. These results suggest that the migration of mesenchymal stem cells is regulated by complex functional interactions between SP, TGF-β, and SDF-1. Thus, understanding the complex functional interactions of these chemotactic stimuli would contribute to ensuring the development of safe and effective combination treatments for the mobilization of BM-MSCs.

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