Adsorption and Sustained‐Release Capacity of Glyphosate on Microporous Corn Starch

2021 ◽  
pp. 2000224
Author(s):  
Xiaoting Dong ◽  
Yifan Bai ◽  
Xian Ma ◽  
Pengli Xue ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Corn Starch ◽  
Release Capacity

Nanofibrous polylactide composite scaffolds with electroactivity and sustained release capacity for tissue engineering

2016 ◽  
Vol 4 (14) ◽  
pp. 2477-2485 ◽  
Author(s):  
Jing Chen ◽  
Juan Ge ◽  
Baolin Guo ◽  
Kun Gao ◽  
Peter X. Ma
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Sustained Release ◽  
Composite Scaffold ◽  
Myoblast Differentiation ◽  
Sustained Drug Release ◽  
Composite Scaffolds ◽  
Release System ◽  
Release Capacity ◽  
Drug Release System

A conveniently fabricated electroactive nanofibrous composite scaffold serves as a sustained drug release system and promotes myoblast differentiation.

scholarly journals High-Amylose Sodium Carboxymethyl Starch Matrices: Development and Characterization of Tramadol Hydrochloride Sustained-Release Tablets for Oral Administration

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Teresa Nabais ◽  
Grégoire Leclair
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Corn Starch ◽  
Water Soluble ◽  
Hydroxyl Groups ◽  
Sustained Drug Release ◽  
Tramadol Hydrochloride ◽  
Carboxymethyl Starch ◽  
High Amylose ◽  
Sodium Carboxymethyl Starch

Substituted amylose (SA) polymers were produced from high-amylose corn starch by etherification of its hydroxyl groups with chloroacetate. Amorphous high-amylose sodium carboxymethyl starch (HASCA), the resulting SA polymer, was spray-dried to obtain an excipient (SD HASCA) with optimal binding and sustained-release (SR) properties. Tablets containing different percentages of SD HASCA and tramadol hydrochloride were produced by direct compression and evaluated for dissolution. Once-daily and twice-daily SD HASCA tablets containing two common dosages of tramadol hydrochloride (100 mg and 200 mg), a freely water-soluble drug, were successfully developed. These SR formulations presented high crushing forces, which facilitate further tablet processing and handling. When exposed to both a pH gradient simulating the pH variations through the gastrointestinal tract and a 40% ethanol medium, a very rigid gel formed progressively at the surface of the tablets providing controlled drug-release properties. These properties indicated that SD HASCA was a promising and robust excipient for oral, sustained drug-release, which may possibly minimize the likelihood of dose dumping and consequent adverse effects, even in the case of coadministration with alcohol.

scholarly journals Bioactive Multilayer Polylactide Films with Controlled Release Capacity of Gallic Acid Accomplished by Incorporating Electrospun Nanostructured Coatings and Interlayers

2019 ◽  
Vol 9 (3) ◽  
pp. 533 ◽  
Author(s):  
Luis Quiles-Carrillo ◽  
Nestor Montanes ◽  
José Lagaron ◽  
Rafael Balart ◽  
Sergio Torres-Giner
Keyword(s):  
Sustained Release ◽  
Gallic Acid ◽  
In Vitro Release ◽  
The Other ◽  
High Transparency ◽  
Release Capacity ◽  
Release Studies ◽  
Vitro Release ◽  
Saline Medium

The present research reports on the development of bi- and multilayer polylactide (PLA) films by the incorporation of electrospun nanostructured PLA coatings and interlayers containing the antioxidant gallic acid (GA) at 40 wt% onto cast-extruded PLA films. To achieve the bilayer structures, submicron GA-loaded PLA fibers were applied on 200-µm cast PLA films in the form of coatings by electrospinning for 1, 2, and 3 h. For the multilayers, the cast PLA films were first coated on one side by electrospinning, then sandwiched with 10-µm PLA film on the other side, and the resultant whole structure was finally thermally post-treated at 150 °C without pressure. Whereas the bilayer PLA films easily delaminated and lacked transparency, the multilayers showed sufficient adhesion between layers and high transparency for deposition times during electrospinning of up to 2 h. The incorporation of GA positively contributed to delaying the thermal degradation of PLA for approximately 10 °C, as all films were thermally stable up to 345 °C. The in vitro release studies performed in saline medium indicated that the GA released from the bilayer PLA films rapidly increased during the first 5 h of immersion while it stabilized after 45–250 h. Interestingly, the PLA multilayers offered a high sustained release of GA, having the capacity to deliver the bioactive for over 1000 h. In addition, in the whole tested period, the GA released from the PLA films retained most of its antioxidant functionality. Thus, during the first days, the bilayer PLA films can perform as potent vehicles to deliver GA while the multilayer PLA films are able to show a sustained release of the natural antioxidant for extended periods.

Sustained release of tea polyphenols from a debranched corn starch–xanthan gum complex carrier

LWT ◽  
2019 ◽  
Vol 103 ◽  
pp. 325-332 ◽  
Author(s):  
Yan Hong ◽  
Jie Yang ◽  
Wei Liu ◽  
Zhengbiao Gu ◽  
Zhaofeng Li ◽  
...  
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Corn Starch ◽  
Tea Polyphenols

Preparation and evaluation of valnemulin hydrochloride taste-masking granules

2021 ◽  
Vol 18 ◽  
Author(s):  
Yongjie Liang ◽  
Danlei Hu ◽  
Yuanyuan Yan ◽  
Dongmei Chen ◽  
Shuyu Xie
Keyword(s):  
Sustained Release ◽  
Residence Time ◽  
Solid Dispersion ◽  
Corn Starch ◽  
The Body ◽  
Self Control ◽  
Angle Of Repose ◽  
Taste Masking ◽  
Wet Granulation ◽  
Valnemulin Hydrochloride

Background: The bitter taste and strong irritation of valnemulin hydrochloride limit its wide clinical application in pigs by oral. Method: In order to improve its palatability and residence time in the body, the valnemulin hydrochloride taste-masking granules with sustained-release were prepared by combining solid dispersion based on fatty acid with wet granulation. The formulation was screened by orthogonal test with content, yield, grain size and angle of repose as evaluation indexes. Result: The results showed that the optimal granules were composed of corn starch, sucrose, citric acid, valnemulin hydrochloride and myristic acid at a ratio of 40: 20: 20: 11: 19. The daily feed intake of pigs in the optimum taste-masking granule groups was similar to that of its self-control, and significantly higher than that in the valnemulin hydrochloride active ingredient group, suggesting that the optimum granules have satisfactory palatability. The prepared granules improved the oral bioavailability of valnemulin hydrochloride by 3.04 folds and extended its mean residence time (MRT) by 2.33 folds. Conclusion: The granules developed in this study could obviously improve the palatability and sustained release of valnemulin hydrochloride. The producing method of granules by combining solid dispersion powder with wet granulation can provide ideas for other drugs with poor palatability and a short half-life.

Preparation of Urea Slow Release Membrane Environment Friendly

2012 ◽  
Vol 482-484 ◽  
pp. 1618-1621 ◽  
Author(s):  
Shu Jiang Wang ◽  
Xing Quan Wang ◽  
Ming Hui Chen
Keyword(s):  
Lactic Acid ◽  
Sustained Release ◽  
Corn Starch ◽  
Slow Release ◽  
Urea Formaldehyde ◽  
Raw Material ◽  
Poly Lactic Acid ◽  
Dialdehyde Starch ◽  
Membrane Absorption ◽  
High Efficient

First, the corn starch was taken as raw material, and then it was broken down by enzymes and fermentation by lactic acid bacteria, and the poly lactic acid was obtained by chemical synthesis. Then the corn starch was taken as raw material again, the dialdehyde starch was obtained by high efficient light-catalytic reactor. Secondly, a certain percentage of dialdehyde starch and urea were mixed together to get urea-formaldehyde resin. Finally, a certain amount of polylactic acid, urea formaldehyde resins and dispersions were put together and mixed in a high-speed stirring to get urea slow release membrane materials. Experimental results showed that it needed 150-300 days degradate completely by 75% poly lactic acid sustained release membrane, while 85% needed 100 -120 days. Single thin membrane absorption test showed that per unit area of the sustained release membrane absorption ability would increase with the poly lactic acid increased, and the absorbent capacity of 85% poly lactic acid of sustained release membrane was 112 times higher than the mass of itself.

scholarly journals Optimization of the spherical integrity for sustained-release alginate microcarriers-encapsulated doxorubicin by the Taguchi method

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
C. T. Pan ◽  
S. T. Chien ◽  
T. C. Chiang ◽  
C. K. Yen ◽  
S. Y. Wang ◽  
...  
Keyword(s):  
Taguchi Method ◽  
Sustained Release ◽  
Sodium Alginate ◽  
Cell Lines ◽  
Calcium Alginate ◽  
Signal To Noise Ratio ◽  
Release Capacity ◽  
Average Size ◽  
Needle Diameter

AbstractThis study aimed to develop biodegradable calcium alginate microcarriers with uniform particle size and spherical integrity for sustained-release targeting transarterial chemoembolization. To determine related parameters including the ratio of cross-linking volume (sodium alginate: CaCl2), concentrations of sodium alginate and CaCl2 solutions, collection distance, flow rate, stirring speed, syringe needle diameter and hardening time to fabricate the microcarriers, the Taguchi method was applied. Using different conditions, a total of 18 groups were prepared. The average size of microspheres from different groups was estimated as ~ 2 mm (range 1.1 to 1.6 mm). Signal-to-noise ratio analysis showed the optimal spherical integrity (F1) achieved when the above parameters were designed as 0.1, 2.5 wt%, 6 wt%, 8 cm, 30 mL/h, 150 rpm, 0.25 mm and 2 h, respectively. The best (F1), middle (F2) and worst (F3) groups were used for further experiments. Fourier-transform infrared spectroscopy spectrum showed that F1, F2 and F3 conformations were distinct from original sodium alginate. Drug-loaded calcium alginate microcarriers demonstrated rougher surfaces compared to microspheres without drug under transmission electron microscopy. Compared to pH 7.4, swelling rates in PBS were decreased at pH 6.5. Encapsulation and loaded efficiencies of the Dox-loaded microcarriers were estimated as ~ 40.617% and ~ 3.517%. In vitro experiments indicated that the F1 Dox-loaded microcarriers provide a well sustained-release efficacy for about two weeks at 37 °C in PBS. Treatments of calcium alginate microcarriers without the Dox in two distinct hepatocellular carcinoma-derived cell lines, Huh-7 and Hep-3B, indicated that these microcarriers were non-toxic. The Dox-loaded microcarriers displayed sustained-release capacity and reduced cell viabilities to ~ 30% in both cell lines on Day 12.

1558: Local Injection of Sustained-Release Antiandrogen Formulation into a Target Prostatic Site: An Experimental Study

2007 ◽  
Vol 177 (4S) ◽  
pp. 515-515
Author(s):  
Nobuyuki Goya ◽  
Kotara Gotanda ◽  
Yasuko Tomizawa ◽  
Hiroshi Toma
Keyword(s):  
Experimental Study ◽  
Sustained Release ◽  
Local Injection
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