Zein-based ultrathin fibers containing ceramic nanofillers obtained by electrospinning. II. Mechanical properties, gas barrier, and sustained release capacity of biocide thymol in multilayer polylactide films

2014 ◽  
Vol 131 (18) ◽  
pp. n/a-n/a ◽  
Author(s):  
Sergio Torres-Giner ◽  
Antonio Martinez-Abad ◽  
Jose Maria Lagaron
Keyword(s):  
Mechanical Properties ◽  
Sustained Release ◽  
Gas Barrier ◽  
Release Capacity ◽  
Ultrathin Fibers

Nanofibrous polylactide composite scaffolds with electroactivity and sustained release capacity for tissue engineering

2016 ◽  
Vol 4 (14) ◽  
pp. 2477-2485 ◽  
Author(s):  
Jing Chen ◽  
Juan Ge ◽  
Baolin Guo ◽  
Kun Gao ◽  
Peter X. Ma
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Sustained Release ◽  
Composite Scaffold ◽  
Myoblast Differentiation ◽  
Sustained Drug Release ◽  
Composite Scaffolds ◽  
Release System ◽  
Release Capacity ◽  
Drug Release System

A conveniently fabricated electroactive nanofibrous composite scaffold serves as a sustained drug release system and promotes myoblast differentiation.

scholarly journals Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 982
Author(s):  
Gustavo Carreño ◽  
Adolfo Marican ◽  
Sekar Vijayakumar ◽  
Oscar Valdés ◽  
Gustavo Cabrera-Barjas ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Polyvinyl Alcohol ◽  
Sustained Release ◽  
Release Kinetics ◽  
Dicarboxylic Acids ◽  
Release Profile ◽  
Significant Activity ◽  
Crosslinking Degree ◽  
Aliphatic Dicarboxylic Acids

A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.

scholarly journals Fabrication Of Glimepiride Datura Stramonium Leaves Mucilage And Poly Vinyl Pyrrolidone Sustained Release Matrix Tablets: In Vitro Evaluation

1970 ◽  
Vol 8 (1) ◽  
pp. 63-72
Author(s):  
Abdul Ahad Hindustan ◽  
U Anand Babu ◽  
K Nagesh ◽  
D Sai Kiran ◽  
K Bindu Madhavi
Keyword(s):  
Mechanical Properties ◽  
Sustained Release ◽  
Datura Stramonium ◽  
Matrix Tablets ◽  
Vinyl Pyrrolidone ◽  
Stability Studies ◽  
Swelling Properties ◽  
Accelerated Stability ◽  
Poly Vinyl Pyrrolidone

The main purpose of the present work was to develop matrix tablets of Glimepiride with Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from Datura stramonium leaves was extracted, isolated, purified and characterized. Physicochemical properties of the dried powdered mucilage of Datura stramonium leaves were studied. Various formulations of Glimepiride Datura stramonium leave mucilage and Poly Vinyl Pyrrolidone were prepared. The formulated tablets were tested for mechanical properties, friability, swelling behavior, in vitro drug release pattern and the dissolution data was treated with mathematical modeling and the optimized formulation was tested for accelerated stability studies. The formulated tablets were found to have good mechanical properties, good swelling properties. The in vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that the dried Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone combination can be used as a matrix forming material for making sustained release matrix tablets. DOI: http://dx.doi.org/10.3126/kuset.v8i1.6044 KUSET 2012; 8(1): 63-72

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