Self-Assembly of Drug-Loaded Liposomes on Genetically Engineered Target-Recognizing M13 Phage: A Novel Nanocarrier for Targeted Drug Delivery

Small ◽  
2009 ◽  
Vol 5 (17) ◽  
pp. 1963-1969 ◽  
Author(s):  
Pascaline Ngweniform ◽  
Gopal Abbineni ◽  
Binrui Cao ◽  
Chuanbin Mao
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Genetically Engineered ◽  
Targeted Drug ◽  
M13 Phage

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

scholarly journals H2S gasotransmitter-responsive polymer vesicles

2016 ◽  
Vol 7 (3) ◽  
pp. 2100-2105 ◽  
Author(s):  
Qiang Yan ◽  
Wei Sang
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Cell Signaling ◽  
Diblock Copolymer ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Polymer Vesicles ◽  
Responsive Polymer ◽  
Targeted Drug

A type of new polymeric vesicle self-assembly byo-azidomethylbenzoate-containing diblock copolymer can respond to the cell signaling molecule hydrogen sulfide (H2S). The intracellular H2S gasotransmitter can trigger biomimetic polymersome disruption for targeted drug delivery.

scholarly journals Targeted drug delivery using genetically engineered diatom biosilica

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Bahman Delalat ◽  
Vonda C. Sheppard ◽  
Soraya Rasi Ghaemi ◽  
Shasha Rao ◽  
Clive A. Prestidge ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Genetically Engineered ◽  
Targeted Drug

Self-Assembly of Morphology-Tunable Architectures from Tetraarylmethane Derivatives for Targeted Drug Delivery

Langmuir ◽  
2013 ◽  
Vol 29 (10) ◽  
pp. 3223-3233 ◽  
Author(s):  
Xinhua Huang ◽  
Young-Il Jeong ◽  
Byeong Kyu Moon ◽  
Lidong Zhang ◽  
Dae Hwan Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeted Drug

scholarly journals Pillar[5]arene-based amphiphilic supramolecular brush copolymers: fabrication, controllable self-assembly and application in self-imaging targeted drug delivery

2016 ◽  
Vol 7 (40) ◽  
pp. 6178-6188 ◽  
Author(s):  
Guocan Yu ◽  
Run Zhao ◽  
Dan Wu ◽  
Fuwu Zhang ◽  
Li Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Targeted Drug

Here we construct the first pillararene-based amphiphilic supramolecular brush copolymer, which can be utilized as a targeting self-imaging drug delivery vehicle.

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