Fluorophore Tagged Mixed Ligand Copper(II) Complexes: Synthesis, Structural Characterization, Protein Binding, DNA Cleavage and Anticancer Activity

2021 ◽  
Vol 6 (45) ◽  
pp. 12666-12676
Author(s):  
Sabiha A. Shaikh ◽  
Satish S. Bhat ◽  
Vidyanand K. Revankar ◽  
Badarinath D. Kulkarni ◽  
Karthik Kumara ◽  
...  
Keyword(s):  
Protein Binding ◽  
Anticancer Activity ◽  
Structural Characterization ◽  
Dna Cleavage ◽  
Mixed Ligand

Mixed-Ligand Copper(II)-phenolate Complexes:  Effect of Coligand on Enhanced DNA and Protein Binding, DNA Cleavage, and Anticancer Activity

2007 ◽  
Vol 46 (20) ◽  
pp. 8208-8221 ◽  
Author(s):  
Venugopal Rajendiran ◽  
Ramasamy Karthik ◽  
Mallayan Palaniandavar ◽  
Helen Stoeckli-Evans ◽  
Vaiyapuri Subbarayan Periasamy ◽  
...  
Keyword(s):  
Protein Binding ◽  
Anticancer Activity ◽  
Dna Cleavage ◽  
Mixed Ligand

Synthesis, Structural Characterization, Protein Binding, DNA Cleavage and Anticancer Activity of Fluorophore Labelled Copper(II) Complexes Based on 1,8-Naphthalimide Conjugate

2021 ◽  
Author(s):  
Sabiha Shaikh ◽  
Satish Shantaram Bhat ◽  
Vidyanand K Revankar ◽  
Pooja Lokesh Hedge ◽  
Anup N. Kate ◽  
...  
Keyword(s):  
Protein Binding ◽  
Anticancer Activity ◽  
Structural Characterization ◽  
Dna Cleavage

The two novel fluorophore labelled copper(II) complexes [Cu(L)2(DMF)Cl2] (1) and [Cu(phen)(L)Cl2] (2), (Where, L = N-(3-pyridyl)-1, 8-naphthalimide, phen = 1,10- phenanthroline, DMF = dimethylformamide) incorporating fluorophore N-(3-pyridyl)-1, 8-naphthalimide and 1,10-phenanthroline...

Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel(ii) bis(thiosemicarbazone) complexes

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46031-46049 ◽  
Author(s):  
Jebiti Haribabu ◽  
Kumaramangalam Jeyalakshmi ◽  
Yuvaraj Arun ◽  
Nattamai S. P. Bhuvanesh ◽  
Paramasivan Thirumalai Perumal ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Protein Binding ◽  
Anticancer Activity ◽  
Dna Cleavage ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Thiosemicarbazone Complexes ◽  
Ct Dna

Cytotoxic nickel(ii) complexes with an N-substituted isatin thiosemicarbazone were synthesized and their interaction with CT DNA and BSA protein was investigated, which was supported by molecular docking studies.

Mixed-ligand copper(ii)–sulfonamide complexes: effect of the sulfonamide derivative on DNA binding, DNA cleavage, genotoxicity and anticancer activity

2013 ◽  
Vol 42 (28) ◽  
pp. 10244 ◽  
Author(s):  
Marta González-Álvarez ◽  
Alejandro Pascual-Álvarez ◽  
Lucas del Castillo Agudo ◽  
Alfonso Castiñeiras ◽  
Malva Liu-González ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Sulfonamide Derivative

Mixed-ligand copper(ii) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity

2016 ◽  
Vol 45 (22) ◽  
pp. 9073-9087 ◽  
Author(s):  
Wen-Jing Lian ◽  
Xin-Tian Wang ◽  
Cheng-Zhi Xie ◽  
He Tian ◽  
Xue-Qing Song ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Protein Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Schiff Base Complexes ◽  
Biological Features

Four novel mixed-ligand copper(ii) Schiff base complexes were synthesized and characterized. The biological features of the complexes and how acetic auxiliary ligands manipulate these features were investigated.

DNA and protein binding, double-strand DNA cleavage and cytotoxicity of mixed ligand copper(II) complexes of the antibacterial drug nalidixic acid

2017 ◽  
Vol 174 ◽  
pp. 1-13 ◽  
Author(s):  
Rangasamy Loganathan ◽  
Mani Ganeshpandian ◽  
Nattamai S.P. Bhuvanesh ◽  
Mallayan Palaniandavar ◽  
Amsaveni Muruganantham ◽  
...  
Keyword(s):  
Protein Binding ◽  
Nalidixic Acid ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Antibacterial Drug ◽  
Double Strand Dna
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