scholarly journals Two‐Photon Detection of Organotin Schiff Base Complexes in Cancer Cells

2020 ◽  
Vol 5 (5) ◽  
pp. 1623-1627
Author(s):  
Jessica C. Berrones‐Reyes ◽  
Blanca M. Muñoz‐Flores ◽  
Ashanti Concepción Uscanga‐Palomeque ◽  
Rosa Santillán ◽  
Casiano Del Angel‐Mosqueda ◽  
...  
Keyword(s):  
Schiff Base ◽  
Cancer Cells ◽  
Schiff Base Complexes ◽  
Photon Detection ◽  
Two Photon

scholarly journals Use of a Zebrafish Model to Evaluate Toxicity of Schiff Base Complexes of Copper (II) and Zinc (II) as Possible Antineoplastic Agents

Proceedings ◽  
2019 ◽  
Vol 22 (1) ◽  
pp. 11
Author(s):  
Claudia Cardozo ◽  
Andreas Reiber ◽  
Veronica Akle
Keyword(s):  
Schiff Base ◽  
Cancer Cells ◽  
Antineoplastic Agents ◽  
Promising Result ◽  
Organometallic Complexes ◽  
Schiff Base Complexes ◽  
World Health ◽  
Proliferating Cells ◽  
Zebrafish Model ◽  
Toxic Activity

Cancer continues to be one of the leading causes of death, according to the World Health Organization, and chemotherapy is its principal treatment. Organometallic complexes with copper (II) and zinc (II) with Schiff bases as ligand, capable of interacting with cancer cells’ DNA under physiological conditions, may work as good chemotherapy agents because they are less toxic to healthy cells than to cancerous ones. In view of the above, this work focuses on obtaining new Schiff base ligands and their copper and zinc complexes and characterizing them by nuclear magnetic resonance, mass spectrometry, infrared spectroscopy, and other spectroscopic and spectrometric techniques. The objective is to evaluate the toxic activity of the new molecules using the fast proliferating cells of the zebrafish model during development. The toxicity test was performed in zebrafish embryos at 8, 24, 48 and 72 h post fertilization, and a survival and malformation index were registered. Preliminary results show a dose-related effect of the designed Schiff ligands and complexes on the toxicity of the zebrafish embryo and larvae. The survival and malformation index are more severe when exposure occurs during early developmental stages, when cell division is higher due to rapid organization and growth of the new organism. This is a promising result, as the molecules might be cytotoxic to highly proliferating cells, as it occurs in cancer cells. This work represents one of the very few examples that use the zebrafish model to evaluate the cytotoxic activity of Schiff base complexes. Developing the animal model to test the effect of Schiff ligands and their complexes is an important first step to assess the effectiveness of new molecules as antineoplastic agents.

Potential application of two cobalt (III) Schiff base complexes in cancer chemotherapy: Leads from a study using breast and lung cancer cells

2021 ◽  
pp. 105201
Author(s):  
Balakrishnan Gowdhami ◽  
Subramanian Ambika ◽  
Balakrishnan Karthiyayini ◽  
Venkatesan Ramya ◽  
Balamuthu Kadalmani ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Schiff Base ◽  
Cancer Cells ◽  
Cancer Chemotherapy ◽  
Potential Application ◽  
Schiff Base Complexes ◽  
Lung Cancer Cells

A new class of quadruplex DNA-binding nickel Schiff base complexes

2020 ◽  
Vol 49 (15) ◽  
pp. 4843-4860 ◽  
Author(s):  
Son Q. T. Pham ◽  
Nawal Assadawi ◽  
Jadon Wells ◽  
Reece A. Sophocleous ◽  
Kimberley J. Davis ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cells ◽  
Schiff Base Complex ◽  
Schiff Base Complexes ◽  
Selective Binding ◽  
Quadruplex Dna ◽  
Base Complex ◽  
New Class ◽  
Binding Behaviour

A new nickel Schiff base complex shows selective binding behaviour towards quadruplex DNA and cytotoxicity against cancer cells.

Two new POM-based compounds modified by lanthanide–Schiff base complexes with interesting NLO properties

2018 ◽  
Vol 74 (11) ◽  
pp. 1370-1377 ◽  
Author(s):  
Xi-Ming Luo ◽  
Chen-Hui Cui ◽  
Jia-Peng Cao ◽  
Qing-Fang Lin ◽  
Yan Xu
Keyword(s):  
Schiff Base ◽  
Nonlinear Optics ◽  
Three Dimensional ◽  
Schiff Base Complex ◽  
Schiff Base Complexes ◽  
Photon Absorption ◽  
X Ray Diffraction ◽  
Hydrothermal Conditions ◽  
X Ray ◽  
Two Photon

Two POM-based lanthanide derivatives, namely {triaqua[2,6-diacetylpyridine bis(semicarbazone)-κ5 O,N,N′,N′′,O′]terbium(III)}-μ-oxido-[tricosa-μ2-oxido-dodecaoxido-μ12-phosphato-dodecamolybdenum(VI)] pentahydrate (1), [Tb(C11H15N7O2)(H2O)3][PMo12O40]·5H2O, and the dysprosium(III) analogue (2), have been isolated successfully by the reaction of Keggin–POM [PMo12O40]3− (abbreviated as PMo12 ), the Ln3+ ion and the Schiff base 2,6-diacetylpyridine bis(semicarbazone) (DAPSC) ligand under hydrothermal conditions. [Ln(DAPSC)(H2O)3][PMo12O40]·5H2O is a PMo12 -supported cluster featuring a lanthanide–Schiff base complex [denoted Ln– L (Schiff base)]. Single-crystal X-ray diffraction analysis reveals that the LnIII ion is in a distorted tricapped trigonal prismatic arrangement, coordinated by six O atoms and three N atoms. Two O atoms and three N atoms are provided by one DAPSC ligand, while the additional O atoms originate from a PMo12 cluster and three water molecules. Hydrogen-bonding interactions between adjacent clusters form an interesting three-dimensional supramolecular structure. The identities of 1 and 2 were characterized by IR spectroscopy, thermogravimetric analysis and powder X-ray diffraction. Interestingly, both compounds possess excellent two-photon absorption (TPA) responses to the third-order nonlinear optics (NLO) (2264 GM for 1 and 941 GM for 2), suggesting that they have potential applications in the field of nonlinear optics (NLO). To our knowledge, 1 and 2 are the first POM-based Ln– L (Schiff base) complexes showing excellent two-photon responses. Meanwhile, the electrochemical properties of both compounds were studied in detail.

scholarly journals SYNTHESIS, SPECTRAL CHARACTERIZATION OF SCHIFF BASE COMPLEXES BASED ON PYRIMIDINE MOIETY WITH MOLECULAR DOCKING WITH BIOMOLECULES

2018 ◽  
Vol 11 (10) ◽  
pp. 93
Author(s):  
Mohanambal D ◽  
Arulantony S
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Cancer Cells ◽  
Elemental Analysis ◽  
Condensation Reaction ◽  
Spectral Characteristics ◽  
Schiff Base Complexes ◽  
Human Epidermis ◽  
Schiff Base Ligands ◽  
13C Nuclear Magnetic Resonance

Objective: Aim of this study is to synthesize new bidentate complexes of type MX2. nH2O with 4 amino antipyrine and ethyl 4-methyl-2-oxo-6- phenylhexahydropyrimidine-5-carboxylate (DHPM) and to characterize their properties, namely elemental analysis, conductivity measurements, and spectral characteristics and to establish the binding between the Schiff base ligands and complexes with human epidermis cancer cells (Hep-2) through molecular docking.Method: A new bidentate complexes were synthesized by condensation reaction of MX2·nH2O (M = Cu (II), Zn (II), Co (II)) with 4-aminoantipyrine (A) and DHPM in methanol under atmospheric pressure.Results: All the compounds have been characterized by elemental analysis, conductance measurements, magnetic moments, and spectroscopy techniques such as ultraviolet–visible, infrared (IR), 1H and 13C nuclear magnetic resonance, and electron spin resonance (ESR). The IR showed that nature of functional group present in the ligand (Lp) acts as neutral bidentate through the azomethane nitrogen atom and carbonyl oxygen moiety and its complexes formation. The ESR spectral data of copper complex provided information about their structure on the basis of Hamiltonian parameters and degree of covalency. The antimicrobial (Escherichia coli, Salmonella typhi, Bacillus subtilis, and aureus) and antifungal (Candida and Aspergillus niger) activities of the complexes were tested against various microorganism by disc diffusion method.Conclusion: The antimicrobial activity indicates that the metal complexes are more active than the ligand. Molecular docking was used to predict the binding between the Schiff base ligands and complexes with human epidermis cancer cells (Hep-2).

scholarly journals Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Ikechukwu P. Ejidike ◽  
Peter A. Ajibade
Keyword(s):  
Schiff Base ◽  
Cancer Cells ◽  
Metal Ion ◽  
Schiff Base Complexes ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Melanoma Cancer ◽  
Sulforhodamine B Assay ◽  
Mcf 7

Mononuclear Ru(III) complexes of the type [Ru(LL)Cl2(H2O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], andN-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes.In vitroanticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl2(H2O)] showed the highest activity with IC50valves of3.57±1.09,6.44±0.38, and9.06±1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl2(H2O)] > [Ru(HME)Cl2(H2O)] > [Ru(DAE)Cl2(H2O)] > [Ru(MBE)Cl2(H2O)].

Co(II) and Cu(II) Schiff base complexes of bis(N-(4-diethylamino-2-methylphenyl)-3,5-di-tert-butylsalicylaldimine): Electrochemical and X-ray structural study

2008 ◽  
Vol 19 (5) ◽  
pp. 749-755 ◽  
Author(s):  
Mahmut Ulusoy ◽  
Hasan Karabıyık ◽  
Rafet Kılınçarslan ◽  
Muhittin Aygün ◽  
Bekir Çetinkaya ◽  
...  
Keyword(s):  
Schiff Base ◽  
Structural Study ◽  
Schiff Base Complexes ◽  
X Ray

Functional substituted Cu(II) Schiff base complexes, syntheses, X-ray and theoretical characterizations, and investigations of their polyphenol oxidase- and peroxidase-like activities

2021 ◽  
Vol 1232 ◽  
pp. 129975
Author(s):  
Murat Tuna ◽  
Salih Zeki Yildiz ◽  
Gulnur Arabaci ◽  
Zeynep Denli ◽  
Nagihan Çaylak Delibaş ◽  
...  
Keyword(s):  
Schiff Base ◽  
Polyphenol Oxidase ◽  
Schiff Base Complexes ◽  
X Ray
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