A new class of quadruplex DNA-binding nickel Schiff base complexes

2020 ◽  
Vol 49 (15) ◽  
pp. 4843-4860 ◽  
Author(s):  
Son Q. T. Pham ◽  
Nawal Assadawi ◽  
Jadon Wells ◽  
Reece A. Sophocleous ◽  
Kimberley J. Davis ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cells ◽  
Schiff Base Complex ◽  
Schiff Base Complexes ◽  
Selective Binding ◽  
Quadruplex Dna ◽  
Base Complex ◽  
New Class ◽  
Binding Behaviour

A new nickel Schiff base complex shows selective binding behaviour towards quadruplex DNA and cytotoxicity against cancer cells.

The effect of isomerism and other structural variations on the G-quadruplex DNA-binding properties of some nickel Schiff base complexes

2020 ◽  
Vol 49 (30) ◽  
pp. 10360-10379 ◽  
Author(s):  
Son Q. T. Pham ◽  
Christopher Richardson ◽  
Celine Kelso ◽  
Anthony C. Willis ◽  
Stephen F. Ralph
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Structural Variations ◽  
Binding Properties ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Properties ◽  
Binding Behaviour

Changing the position of pendant groups on nickel Schiff base complexes can alter their binding behaviour towards quadruplex DNA.

Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes

2018 ◽  
Vol 47 (38) ◽  
pp. 13573-13591 ◽  
Author(s):  
Kimberley J. Davis ◽  
Nawal M. O. Assadawi ◽  
Son Q. T. Pham ◽  
Monica L. Birrento ◽  
Christopher Richardson ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Nickel Complexes ◽  
Schiff Base Complexes ◽  
Binding Ability ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Effect Of Structure

The synthesis of two new series of nickel complexes is described, along with their ability to bind to duplex and quadruplex DNA structures.

scholarly journals DNA binding and cleavage activity by a mononuclear iron(II)Schiff base complex: Synthesis and structural characterization

2013 ◽  
Vol 125 (5) ◽  
pp. 1161-1168 ◽  
Author(s):  
ABHIJIT PAL ◽  
BHASKAR BISWAS ◽  
MERRY MITRA ◽  
SUBRAMANIYAM RAJALAKSHMI ◽  
CHANDRA SHEKHAR PUROHIT ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Structural Characterization ◽  
Schiff Base Complex ◽  
Base Complex ◽  
Mononuclear Iron ◽  
Cleavage Activity ◽  
Dna Binding And Cleavage

Synthesis, Characterization, and Antimicrobial Activities of New Organic-Inorganic Hybird Compound Based on Polyoxovanadate and Metal-Schiff-Base Complex

2015 ◽  
Vol 1105 ◽  
pp. 215-219
Author(s):  
Qiong Wu ◽  
Xiao Lin Ji ◽  
Lu Jing ◽  
Hong Ping Ju ◽  
Hai Wang
Keyword(s):  
Schiff Base ◽  
Human Cancer ◽  
Synergetic Effect ◽  
Schiff Base Complex ◽  
Antimicrobial Activities ◽  
Schiff Base Complexes ◽  
X Ray Diffraction ◽  
Base Complex ◽  
X Ray ◽  
Vis Spectroscopy

The reaction of polyoxovanadate and metal-Schiff base complex resulted in the formation of a new organic-inorganic hybrid compounds with the formula Na2[Mn (Salen)(H2O)2]4[V10O28]·9H2O (1) (salen=N,N’-ethylene-bis (salicylideneiminate). Compound 1 have been structurally characterized by IR, UV-vis spectroscopy and single crystal X-ray diffraction. Crystal data for 1: Triclinic, P-1, a=14.1123(3)Å, b=13.9397(7) Å, c=14.2564(5)Å, α=65.4160(9)°, β=81.3920(6)°, γ=89.5740(7) °. Structural analyses revealed that compound 1 represent a rare example of isopolyoxovanadate based metal-Schiff-base complexes, moreover, this is the first POM based metal Schiff-base complex isolated in aqueous solution medium, which may also propose a green chemical way to the synthesis of POM based hybrid. Compare with isopolyoxovanadate precusor Na6 [V10O28], compound 1 exhibit higher antimicrobial activities against human cancer cell, the phenomenon can be explained by the synergetic effect between POM and Schiff-base complex.

Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy

2019 ◽  
Vol 55 (54) ◽  
pp. 7852-7855 ◽  
Author(s):  
Qian Cao ◽  
Jing Yang ◽  
Hang Zhang ◽  
Liang Hao ◽  
Gang-Gang Yang ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complex ◽  
Schiff Base Complexes ◽  
Specific Therapy ◽  
Base Complex ◽  
Cell Synthesis

A facile and cheap strategy based on visualized in-cell synthesis of theranostic Zn Schiff base complexes realizes cancer-specific therapy.

Cytotoxicity activity, in silico molecular docking, protein- and DNA-binding study of a new Ni(II) Schiff base complex

2018 ◽  
Vol 71 (16-18) ◽  
pp. 2740-2766 ◽  
Author(s):  
Niladri Biswas ◽  
Sumit Khanra ◽  
Arnab Sarkar ◽  
Shamee Bhattacharjee ◽  
Deba Prasad Mandal ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Dna Binding ◽  
In Silico ◽  
Schiff Base Complex ◽  
Binding Study ◽  
Base Complex ◽  
Cytotoxicity Activity ◽  
In Silico Molecular Docking ◽  
Docking Protein

Flexible Ru II Schiff Base Complexes: G‐Quadruplex DNA Binding and Photo‐Induced Cancer Cell Death

2020 ◽  
Vol 26 (61) ◽  
pp. 13849-13860
Author(s):  
Martin Gillard ◽  
Justin Weynand ◽  
Hugues Bonnet ◽  
Frédérique Loiseau ◽  
Anabelle Decottignies ◽  
...  
Keyword(s):  
Cell Death ◽  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cell ◽  
Schiff Base Complexes ◽  
Quadruplex Dna ◽  
Cancer Cell Death ◽  
G Quadruplex
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