Rational Design of Polypeptide-Based Block Copolymer for Nonviral Gene Delivery

2017 ◽  
Vol 2 (36) ◽  
pp. 12006-12013 ◽  
Author(s):  
Radostina Kalinova ◽  
Jordan A. Doumanov ◽  
Kirilka Mladenova ◽  
Dushica Janevska ◽  
Milena Georgieva ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Rational Design ◽  
Nonviral Gene Delivery

scholarly journals Glucose-Responsive Gene Delivery at Physiological pH through Tertiary-Amine Stabilized Boronate-PVA Particles Synthesized by One-Pot Reaction

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 62
Author(s):  
Mangesh Morey ◽  
Akshay Srivastava ◽  
Abhay Pandit
Keyword(s):  
Gene Delivery ◽  
Fold Increase ◽  
Nonviral Gene Delivery ◽  
Luciferase Reporter ◽  
Hydrodynamic Diameter ◽  
Luciferase Reporter Gene ◽  
One Pot ◽  
Gaussia Luciferase ◽  
Nih3t3 Cells ◽  
The Stability

We report a physiologically stable and cytocompatible glucose-responsive nonviral gene delivery system made up of boronate functionalized polymeric material. Herein, we utilize boronate cis-diol interactions to develop a glucose-responsive submicron particle (SMP) system. The stability of the boronate interaction at a physiological pH was achieved by copolymerization of dimethyl aminoethyl methacrylate (DMAEMA) with acrylamidophenylboronic acid (AAPBA) and the formation of a complex with polyvinylalcohol (PVA) which is governed by cis-diol interactions. The shift in hydrodynamic diameter of SMPs was observed and correlated with increasing glucose concentrations at a physiological pH. Optimal transfection was observed for a 5 µg dose of the gaussia luciferase reporter gene in NIH3T3 cells without any adverse effect on cellular viability. The destabilization of the AAPBA–PVA complex by interacting with glucose allowed the release of encapsulated bovine serum albumin (BSA) in a glucose-responsive manner. In total, 95% of BSA was released from SMPs at a 50 mM glucose concentration after 72 h. A two-fold increase in transfection was observed in 50 mM glucose compared to that of 10 mM glucose.

Rational Design and Modification of High-k Bis(double-stranded) Block Copolymer for High Electrical Energy Storage Capability

2018 ◽  
Vol 30 (3) ◽  
pp. 1102-1112 ◽  
Author(s):  
Jie Chen ◽  
Yuxin Wang ◽  
Hongfei Li ◽  
Huijing Han ◽  
Xiaojuan Liao ◽  
...  
Keyword(s):  
Energy Storage ◽  
Block Copolymer ◽  
Rational Design ◽  
Electrical Energy ◽  
Electrical Energy Storage ◽  
High K

Effect of Polymer Ionization on the Interaction with DNA in Nonviral Gene Delivery Systems

2003 ◽  
Vol 4 (3) ◽  
pp. 683-690 ◽  
Author(s):  
Uracha Rungsardthong ◽  
Touraj Ehtezazi ◽  
Lindsey Bailey ◽  
Steven P. Armes ◽  
Martin C. Garnett ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Nonviral Gene Delivery

Photodegradable Neutral-Cationic Brush Block Copolymers for Nonviral Gene Delivery

2014 ◽  
Vol 9 (8) ◽  
pp. 2148-2155 ◽  
Author(s):  
Xianglong Hu ◽  
Yang Li ◽  
Tao Liu ◽  
Guoying Zhang ◽  
Shiyong Liu
Keyword(s):  
Block Copolymers ◽  
Gene Delivery ◽  
Nonviral Gene Delivery

Structure−Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Nonviral Gene Delivery

2006 ◽  
Vol 49 (22) ◽  
pp. 6522-6531 ◽  
Author(s):  
Jianjun Cheng ◽  
Ryan Zeidan ◽  
Swaroop Mishra ◽  
Aijie Liu ◽  
Suzie H. Pun ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Function ◽  
Transgene Expression ◽  
Nonviral Gene Delivery ◽  
Function Correlation

scholarly journals An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives

2014 ◽  
pp. 419 ◽  
Author(s):  
Liqun Yang ◽  
Xuan Liang ◽  
Xianyue Ren ◽  
Zhenzhen Liu ◽  
Yingliang Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector

scholarly journals Breaking up the correlation between efficacy and toxicity for nonviral gene delivery

2007 ◽  
Vol 104 (36) ◽  
pp. 14454-14459 ◽  
Author(s):  
M. Breunig ◽  
U. Lungwitz ◽  
R. Liebl ◽  
A. Goepferich
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery

Layer-by-Layer Biomimetic Microgels for 3D Cell Culture and Nonviral Gene Delivery

2021 ◽  
Author(s):  
Bruna G. Carvalho ◽  
Franciele F. Vit ◽  
Hernandes F. Carvalho ◽  
Sang W. Han ◽  
Lucimara G. de la Torre
Keyword(s):  
Cell Culture ◽  
Gene Delivery ◽  
3D Cell Culture ◽  
Nonviral Gene Delivery ◽  
Layer By Layer

scholarly journals Nonviral gene delivery of erythropoietin by mesenchymal stromal cells

Gene Therapy ◽  
2011 ◽  
Vol 19 (5) ◽  
pp. 550-560 ◽  
Author(s):  
F Scheibe ◽  
N Gladow ◽  
P Mergenthaler ◽  
A H Tucker ◽  
A Meisel ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Nonviral Gene Delivery
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