Spectrally Accurate Quantitative Analysis of Isotope Labeled Compounds

Author(s):  
Don Kuehl ◽  
Yongdong Wang ◽  
Peter L. Wang ◽  
Dawei Zhou
Author(s):  
V. V. Damiano ◽  
R. P. Daniele ◽  
H. T. Tucker ◽  
J. H. Dauber

An important example of intracellular particles is encountered in silicosis where alveolar macrophages ingest inspired silica particles. The quantitation of the silica uptake by these cells may be a potentially useful method for monitoring silica exposure. Accurate quantitative analysis of ingested silica by phagocytic cells is difficult because the particles are frequently small, irregularly shaped and cannot be visualized within the cells. Semiquantitative methods which make use of particles of known size, shape and composition as calibration standards may be the most direct and simplest approach to undertake. The present paper describes an empirical method in which glass microspheres were used as a model to show how the ratio of the silicon Kα peak X-ray intensity from the microspheres to that of a bulk sample of the same composition correlated to the mass of the microsphere contained within the cell. Irregular shaped silica particles were also analyzed and a calibration curve was generated from these data.


2017 ◽  
Vol 89 (20) ◽  
pp. 10850-10857 ◽  
Author(s):  
Águeda Molinero-Fernández ◽  
María Moreno-Guzmán ◽  
Miguel Ángel López ◽  
Alberto Escarpa

1986 ◽  
Vol 69 ◽  
Author(s):  
C. R. Helms

AbstractAlthough classical materials characterization methods have existed for many years, modern microanalytical techniques had their start just over twenty years ago. In this paper, I will discuss some of the common techniques available today including AES, XPS, or ESCA, RBS, SIMS, and EDAX. A comparison of the key capabilities and limitations will be given including sensitivity, spatial resolution, quantitative analysis, nondestructive testing, chemical state determination, and analysis speed. It is clear that the reason each of these techniques still exists as commercial instrumentation is that each provides a unique set of capabilities, but also a unique set of limitations. To become viable in the materials analysis arena, a new technique must offer a significant extension of the capabilities already available but not at the cost of too severe a set of limitations. Examples would be the development of tools that offer both high sensitivity with accurate quantitative analysis, or good spatial resolution with high sensitivity, or minimal damage but good spatial resolution, etc. A number of papers in this volume will describe the details of these emerging technologies which provide advances in these areas; and I will attempt here to put a number of these new developments in perspective with regard to the more commonplace techniques available.


Author(s):  
Matthew Pitt

This chapter focuses on the signals recorded with needle electromyography (EMG) and the measurement of their specific parameters. These parameters include duration, amplitude, number of phases, and stability. The concept of the electrophysiologic biopsy and the explanation of unusual findings seen on EMG are introduced. In relation to the interference pattern, discussions of the firing rate, recruitment order, and interference pattern are given. Moving from the theoretical explanation of the findings, the problems of the accurate quantitative analysis of the motor unit potential are discussed and measures to improve quantification, particularly in children, are highlighted. The importance of filter settings, the storage of signals, and the different ways of collecting and analysing the potentials are all covered. This section finishes with discussion of the normative range for motor unit duration, and concludes with the automatic analysis of the interference pattern, including turns/amplitude analysis, number of short segments measurement, and envelope analysis.


2015 ◽  
Vol 7 (16) ◽  
pp. 6804-6809 ◽  
Author(s):  
Cai-Xia Shi ◽  
Zeng-Ping Chen ◽  
Yao Chen ◽  
Ru-Qin Yu

Accurate quantitative analysis of hormones in cosmetics was achieved through the combination of an advanced model with LC-MS/MS, even when significant variations occur in the sensitivity and signal stability of LC-MS/MS.


1996 ◽  
Vol 06 (01n02) ◽  
pp. 367-373
Author(s):  
HUIYING YAO ◽  
CHENGZHI JIN ◽  
JINGXIA ZHANG ◽  
BENJIE WU

Application of PiXE On biology, medicine and environment has been successful in the last twenty years. However, with the development of science and technique, lower detectable limit, sub-ppm sensitivity, more accurate quantitative analysis and the element chemical state information were presented which can not be achieved by PIXE. The synchrotron radiation as an excitation source to induce X-ray emission (SXRF) is a very powerful method with all the above requirements. In this paper the advantages of SXRF were discussed and compared with PIXE. The article shows our work on biological field by PIXE and SXRF also.


2018 ◽  
Vol 90 (3) ◽  
pp. 1595-1600 ◽  
Author(s):  
Bertrand Plainchont ◽  
Daisy Pitoux ◽  
Mathieu Cyrille ◽  
Nicolas Giraud

2011 ◽  
Vol 103 ◽  
pp. 343-347
Author(s):  
Xin Bian ◽  
Xin Zhou ◽  
Hong Fang ◽  
Ke Liu ◽  
Xiao Chuan Gan ◽  
...  

Propagation of uncertainty is a key factor in uncertainty evaluation. We propose a method using data visualization and numerical analysis for evaluating propagation of uncertainty. In this paper, the main stages of the method are described. Then, the implementation of the method in linear and nonlinear model is illustrated through some examples. These examples show appropriate use of data visualization and numerical analysis can be helpful to provide a concise qualitative overview and accurate quantitative analysis for the uncertainty.


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