Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis

Russell J. Mortishire-Smith; Desmond O'Connor; Jose M. Castro-Perez; Jane Kirby

doi:10.1002/rcm.2111

Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2111 ◽

2005 ◽

Vol 19 (18) ◽

pp. 2659-2670 ◽

Cited By ~ 99

Author(s):

Russell J. Mortishire-Smith ◽

Desmond O'Connor ◽

Jose M. Castro-Perez ◽

Jane Kirby

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Data Analysis ◽

Drug Discovery ◽

High Resolution ◽

Time Of Flight ◽

Flight Mass Spectrometry ◽

Metabolic Route ◽

Automated Data Analysis ◽

Early Drug

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Characterization of eleutheroside B metabolites derived from an extract of Acanthopanax senticosus Harms by high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis

Biomedical Chromatography ◽

10.1002/bmc.2688 ◽

2012 ◽

Vol 26 (10) ◽

pp. 1269-1275 ◽

Cited By ~ 11

Author(s):

Fang Lu ◽

Qiang Sun ◽

Yun Bai ◽

Shunru Bao ◽

Xuzhao Li ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Data Analysis ◽

High Resolution ◽

Time Of Flight ◽

Acanthopanax Senticosus ◽

Flight Mass Spectrometry ◽

Eleutheroside B ◽

Automated Data Analysis

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Peak capacity optimisation for high resolution peptide profiling in complex mixtures by liquid chromatography coupled to time-of-flight mass spectrometry: Application to the Conus consors cone snail venom

Journal of Chromatography A ◽

10.1016/j.chroma.2012.05.033 ◽

2012 ◽

Vol 1259 ◽

pp. 187-199 ◽

Cited By ~ 27

Author(s):

Philippe J. Eugster ◽

Daniel Biass ◽

Davy Guillarme ◽

Philippe Favreau ◽

Reto Stöcklin ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Time Of Flight ◽

Complex Mixtures ◽

Peak Capacity ◽

Cone Snail ◽

Flight Mass Spectrometry ◽

Mass Spectrometry Application

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High-performance liquid chromatography–high-resolution time-of-flight mass spectrometry in the identification and determination of penicillin and tetracycline group antibiotics in food

Journal of Analytical Chemistry ◽

10.1134/s1061934815110027 ◽

2015 ◽

Vol 70 (11) ◽

pp. 1383-1389 ◽

Cited By ~ 11

Author(s):

V. G. Amelin ◽

A. I. Korotkov

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

High Performance ◽

Time Of Flight ◽

Resolution Time ◽

Flight Mass Spectrometry ◽

Tetracycline Group

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Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry

Analytica Chimica Acta ◽

10.1016/j.aca.2006.09.058 ◽

2007 ◽

Vol 586 (1-2) ◽

pp. 137-146 ◽

Cited By ~ 73

Author(s):

M.E. Touber ◽

M.C. van Engelen ◽

C. Georgakopoulus ◽

J.A. van Rhijn ◽

M.W.F. Nielen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Time Of Flight ◽

Flight Mass Spectrometry ◽

Sports Doping

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Evaluation of the Composition of Vine Shoots and Oak Chips for Oenological Purposes by Superheated Liquid Extraction and High-Resolution Liquid Chromatography–Time-of-Flight/Mass Spectrometry Analysis

Journal of Agricultural and Food Chemistry ◽

10.1021/jf205337a ◽

2012 ◽

Vol 60 (13) ◽

pp. 3409-3417 ◽

Cited By ~ 12

Author(s):

M. Pilar Delgado de la Torre ◽

Feliciano Priego-Capote ◽

María Dolores Luque de Castro

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Time Of Flight ◽

Liquid Extraction ◽

Mass Spectrometry Analysis ◽

Superheated Liquid ◽

Spectrometry Analysis ◽

Oak Chips ◽

Flight Mass Spectrometry

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High-resolution separations of protein isoforms with liquid chromatography time-of-flight mass spectrometry using polymer monolithic capillary columns

Journal of Chromatography A ◽

10.1016/j.chroma.2011.06.049 ◽

2011 ◽

Vol 1218 (32) ◽

pp. 5504-5511 ◽

Cited By ~ 36

Author(s):

Sebastiaan Eeltink ◽

Bert Wouters ◽

Gert Desmet ◽

Mario Ursem ◽

David Blinco ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Time Of Flight ◽

Capillary Columns ◽

Protein Isoforms ◽

Flight Mass Spectrometry ◽

Monolithic Capillary Columns

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Comparison between drug screening by immunoassay and ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry in post-mortem urine

Drug Testing and Analysis ◽

10.1002/dta.1683 ◽

2014 ◽

Vol 7 (5) ◽

pp. 420-427 ◽

Cited By ~ 19

Author(s):

Mira Sundström ◽

Anna Pelander ◽

Ilkka Ojanperä

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

Drug Screening ◽

High Performance ◽

Time Of Flight ◽

Post Mortem ◽

Resolution Time ◽

Flight Mass Spectrometry

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Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4554 ◽

2010 ◽

Vol 24 (11) ◽

pp. 1595-1609 ◽

Cited By ~ 69

Author(s):

A. Vonaparti ◽

E. Lyris ◽

Y. S. Angelis ◽

I. Panderi ◽

M. Koupparis ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Human Urine ◽

Time Of Flight ◽

Doping Control ◽

Resolution Time ◽

Screening Analysis ◽

Rapid Resolution ◽

Flight Mass Spectrometry

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Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry

Journal of Chromatography A ◽

10.1016/j.chroma.2009.04.027 ◽

2009 ◽

Vol 1216 (46) ◽

pp. 8206-8216 ◽

Cited By ~ 159

Author(s):

R.J.B. Peters ◽

Y.J.C. Bolck ◽

P. Rutgers ◽

A.A.M. Stolker ◽

M.W.F. Nielen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

Time Of Flight ◽

Veterinary Drugs ◽

Accurate Mass ◽

Flight Mass Spectrometry

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A metabolomics approach to characterize raw, pasteurized, and ultra-high temperature milk using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry and multivariate data analysis

Journal of Dairy Science ◽

10.3168/jds.2018-14441 ◽

2018 ◽

Vol 101 (11) ◽

pp. 9630-9636 ◽

Cited By ~ 6

Author(s):

Y.D. Zhang ◽

P. Li ◽

N. Zheng ◽

Z.W. Jia ◽

N. Meruva ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Data Analysis ◽

High Temperature ◽

Multivariate Data Analysis ◽

Multivariate Data ◽

Time Of Flight ◽

Ultra Performance Liquid Chromatography ◽

Flight Mass Spectrometry ◽

Ultra High Temperature

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