Thereapeutic response ofTribulus terrestris (gokhru) aqueous extract on hyperoxaluria in male adult rats

1993 ◽  
Vol 7 (2) ◽  
pp. 116-119 ◽  
Author(s):  
D. Sangeeta ◽  
H. Sidhu ◽  
S. K. Thind ◽  
R. Nath ◽  
S. Vaidyanathan
Keyword(s):  
Aqueous Extract ◽  
Adult Rats ◽  
Male Adult

scholarly journals Effects of the Aqueous Extract ofEremomastax speciosa(Acanthaceae) on Sexual Behavior in Normal Male Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
B. Nchegang ◽  
C. Mezui ◽  
F. Longo ◽  
Z. E. Nkwengoua ◽  
A. P. Amang ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Aqueous Extract ◽  
Male Rats ◽  
Normal Male ◽  
Adult Rats ◽  
Male Adult ◽  
Positive Effects ◽  
Posttreatment Period ◽  
And Performance ◽  
Behavior Of Rats

Objective. We studied prosexual effects ofEremomastax speciosaaqueous extract in male adult rats.Materials and Methods. 100 and 500 mg/kg of extract were administered orally (days 0, 1, 4, 7, 14, and 28 (posttreatment)). The sexual behavior of rats receiving a single dose (500 mg/kg) was also evaluated after pretreatment with Lω-NAME (10 mg/kg), haloperidol (1 mg/kg), or atropine (5 mg/kg). Controls received distilled water or testosterone enanthate (20 mg/kg/day/3 days(s.c.)before the test).Results. The extract (days 1–14) had no significant effect on mount, intromission, and ejaculation frequencies but on day 28 (14 days after treatment), it increased frequency of mounts and intromissions at 500 mg/kg. Mount, intromission, and ejaculation latencies reduced and postejaculatory intervals decreased but the effect did not persist 2 weeks after treatment. Extract prosex effects were greatly reduced by atropine and completely abolished by haloperidol, while Lω-NAME increased mount latency and potentiated extract effect on intromission and ejaculation latencies.Conclusion. In summary,E. speciosaextract can have positive effects on male sexual motivation and performance when administered for two weeks at the dose of 500 mg/kg. The effects (dopaminergic and/or cholinergic dependent) tend to appear during the posttreatment period.

scholarly journals Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats

2021 ◽  
Vol 219 ◽  
pp. 112323
Author(s):  
Xiang Zhou ◽  
Tongtong Zhang ◽  
Lebin Song ◽  
Yichun Wang ◽  
Qijie Zhang ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Prenatal Exposure ◽  
Adult Rats ◽  
Male Adult ◽  
Butyl Phthalate

Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats

2016 ◽  
Vol 106 ◽  
pp. 46-55 ◽  
Author(s):  
Bassem Sadek ◽  
Ali Saad ◽  
Dhanasekaran Subramanian ◽  
Mohamed Shafiullah ◽  
Dorota Łażewska ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Adult Rats ◽  
Male Adult ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Histamine H3

Behavioral, hormonal, and neurochemical outcomes of neonatal repeated shaking brain injury in male adult rats

2019 ◽  
Vol 199 ◽  
pp. 118-126 ◽  
Author(s):  
Hiromi Tanaka ◽  
Ayuka Ehara ◽  
Kazuhiko Nakadate ◽  
Kanji Yoshimoto ◽  
Kazutaka Shimoda ◽  
...  
Keyword(s):  
Brain Injury ◽  
Adult Rats ◽  
Male Adult

scholarly journals Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsis

1999 ◽  
Vol 277 (3) ◽  
pp. H1036-H1044 ◽  
Author(s):  
Shaolong Yang ◽  
Mian Zhou ◽  
Douglas J. Koo ◽  
Irshad H. Chaudry ◽  
Ping Wang
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Cardiovascular Response ◽  
Cecal Ligation ◽  
Organ Blood Flow ◽  
Adult Rats ◽  
Male Adult ◽  
Morphological Alterations ◽  
Beneficial Effects ◽  
Renal Oxygen

The cardiovascular response to sepsis includes an early, hyperdynamic phase followed by a late, hypodynamic phase. Although administration of pentoxifylline (PTX) produces beneficial effects in sepsis, it remains unknown whether this agent prevents the transition from the hyperdynamic to the hypodynamic response during the progression of sepsis. To study this, male adult rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP). At 1 h after CLP, PTX (50 mg/kg body wt) or vehicle was infused intravenously over 30 min. At 20 h after CLP (i.e., the late stage of sepsis), cardiac output and organ blood flow were measured by radioactive microspheres. Systemic and regional (i.e., hepatic, intestinal, and renal) oxygen delivery (Do 2) and oxygen consumption (V˙o 2) were determined. Moreover, plasma levels of lactate and alanine aminotransferase (ALT) were measured, and histological examinations were performed. In additional animals, the necrotic cecum was excised at 20 h after CLP, and mortality was monitored for 10 days thereafter. The results indicate that cardiac output, organ blood flow, and systemic and regional Do 2decreased by 36–65% ( P < 0.05) at 20 h after CLP. Administration of PTX early after the onset of sepsis, however, prevented reduction in measured hemodynamic parameters and increased systemic and regional Do 2 andV˙o 2 by 50–264% ( P < 0.05). The elevated levels of lactate (by 173%, P < 0.05) and ALT (by 718%, P < 0.05), as well as the morphological alterations in the liver, small intestine, and kidneys during sepsis were attenuated by PTX treatment. In addition, PTX treatment decreased the mortality rate from 50 to 0% ( P < 0.05) after CLP and cecal excision. Because PTX prevents the occurrence of hypodynamic sepsis, this agent appears to be a useful adjunct for maintaining hemodynamic stability and preventing lethality from sepsis.

scholarly journals Differential effects in male adult rats of lifelong coconut oil exposure versus during early-life only

2019 ◽  
Vol 55 ◽  
pp. 17-27 ◽  
Author(s):  
Fernanda Torres Quitete ◽  
Egberto Gaspar de Moura ◽  
Geórgia Correa Atella ◽  
Patricia Cristina Lisboa ◽  
Elaine de Oliveira
Keyword(s):  
Early Life ◽  
Coconut Oil ◽  
Adult Rats ◽  
Male Adult ◽  
Differential Effects ◽  
Oil Exposure

Mechanical and metabolic alterations in rat diaphragm during electrical stimulation

1989 ◽  
Vol 67 (1) ◽  
pp. 210-220 ◽  
Author(s):  
P. S. Massarelli ◽  
H. J. Green ◽  
R. L. Hughson ◽  
M. T. Sharratt
Keyword(s):  
Duty Cycle ◽  
Adenine Nucleotide ◽  
Isometric Force ◽  
Low Frequency ◽  
Maximal Velocity ◽  
Force Output ◽  
Experimental Conditions ◽  
Adult Rats ◽  
Male Adult ◽  
Fatigue Development

To investigate the hypothesis that the rate of fatigue development is not influenced by the absolute duration of contraction (train duration) and relaxation (off-phase of duty cycle) at constant duty cycle, strips of the diaphragm from 36 male adult rats (mean +/- SD wt 152 +/- 21 g) were stimulated directly for periods of 180, 250, and 320 ms at a constant duty cycle of 50%. The frequency of stimulation was adjusted to produce 40% of maximal tetanic tension at supramaximal voltages. After 30 min of stimulation, analysis of twitch characteristics between control and experimental groups indicated a prolongation of contraction time of 9% (P less than 0.05), an increase in relaxation time of 75% (P less than 0.05), and a decrease in twitch tension by 78% (P less than 0.05). Similarly, reductions (P less than 0.05) in isometric force output at high stimulation frequency (100 Hz) of 58% and at low frequency (20 Hz) of 67% were also noted. These changes were accompanied by an approximately 60% reduction in the maximal velocity of shortening. No difference was observed for any of the mechanical measures between experimental conditions. After 30-min stimulation, decreases of between 43 and 46% were noted for ATP (P less than 0.05) and increases of between three- and fourfold noted for IMP (P less than 0.05). No changes were found for either ADP or AMP. Total adenine nucleotide concentrations declined (P less than 0.05) an average of 24%. As with the mechanical data, no differences were found between the different stimulation conditions. It is concluded that for the conditions studied, fatigue mechanisms become manifest early in the stimulation period and are only minimally altered by the duration of specific contractions provided the relaxation period is of equal duration.

Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation

2020 ◽  
Vol 83 (15-16) ◽  
pp. 559-572 ◽  
Author(s):  
Mariana Gazoli Barbosa ◽  
Bárbara Campos Jorge ◽  
Julia Stein ◽  
Dayana Agnes Santos Ferreira ◽  
Ana Carolina da Silva Barreto ◽  
...  
Keyword(s):  
Sperm Parameters ◽  
Next Generation ◽  
Adult Rats ◽  
Male Adult

scholarly journals Effects of 220 MHz Pulsed Modulated Radiofrequency Field on the Sperm Quality in Rats

2019 ◽  
Vol 16 (7) ◽  
pp. 1286 ◽  
Author(s):  
Ling Guo ◽  
Jia-Jin Lin ◽  
Yi-Zhe Xue ◽  
Guang-Zhou An ◽  
Jun-Ping Zhang ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Caspase 3 ◽  
Sperm Quality ◽  
Enzyme Linked Immunosorbent Assay ◽  
Experimental Conditions ◽  
Adult Rats ◽  
Male Adult ◽  
Rf Exposure ◽  
Apoptosis Related Protein ◽  
Hematoxylin Eosin

Under some occupational conditions, workers are inevitably exposed to high-intensity radiofrequency (RF) fields. In this study, we investigated the effects of one-month exposure to a 220 MHz pulsed modulated RF field at the power density of 50 W/m2 on the sperm quality in male adult rats. The sperm quality was evaluated by measuring the number, abnormality and survival rate of sperm cells. The morphology of testis was examined by hematoxylin–eosin (HE) staining. The levels of secreting factors by Sertoli cells (SCs) and Leydig cells (LCs) were determined by enzyme linked immunosorbent assay (ELISA). The level of cleaved caspase 3 in the testis was detected by immunofluorescence staining. Finally, the expression levels of the apoptosis-related protein (caspase 3, BAX and BCL2) in the testis were assessed by Western blotting. Compared with the sham group, the sperm quality in the RF group decreased significantly. The levels of secreting factors of SCs and the morphology of the testis showed an obvious change after RF exposure. The level of the secreting factor of LCs decreased significantly after RF exposure. The levels of cleaved caspase 3, caspase 3, and the BAX/BCL2 ratio in the testis increased markedly after RF exposure. These data collectively suggested that under the present experimental conditions, 220 MHz pulsed modulated RF exposure could impair sperm quality in rats, and the disruption of the secreting function of LCs and increased apoptosis of testis cells induced by the RF field might be accounted for by this damaging effect.

scholarly journals Age-Dependent Regulation of Lipogenesis in Human and Rat Adipocytes

2004 ◽  
Vol 89 (9) ◽  
pp. 4601-4606 ◽  
Author(s):  
Ashraf F. Kamel ◽  
Svante Norgren ◽  
Karin Strigård ◽  
Anders Thörne ◽  
Hossein Fakhrai-Rad ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucose Transport ◽  
Glucose Transporter ◽  
Age Groups ◽  
Tissue Growth ◽  
Adult Rats ◽  
Male Adult ◽  
Rat Adipocytes ◽  
Transporter Protein ◽  
Age Dependent

The regulation of adipocyte metabolism is of importance for adipose tissue growth and therefore also for the development of obesity. This study was designed to investigate the regulation of basal and insulin-induced lipogenesis, glucose transport, and glucose transporter protein expression in human and rat adipocytes from different age groups. The study included 21 infants, 21 children, nine adults, and 80 male weaned and 20 male adult Fischer rats. The lipogenesis experiments were performed under conditions at which glucose transport is rate limiting. Basal lipogenesis was approximately three times higher in infants and children than in adults, whereas insulin-induced lipogenesis was two times higher in infants than in children and adults. In rats, basal lipogenesis, insulin-induced lipogenesis, and insulin sensitivity were two times higher in weaned than in adult animals. Moreover, basal and insulin-induced glucose transport were two times higher in weaned than in adult rats. No differences were detected in GLUT1 or GLUT4 content between any of the age groups in human or in rat adipocytes. In conclusion, basal and insulin-stimulated lipogenesis are increased in adipocytes early in life. This may promote adipose tissue growth in early age. The data indicate that age-dependent variation in basal and insulin-stimulated lipogenesis is differently regulated.

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