Behavioral, hormonal, and neurochemical outcomes of neonatal repeated shaking brain injury in male adult rats

2019 ◽  
Vol 199 ◽  
pp. 118-126 ◽  
Author(s):  
Hiromi Tanaka ◽  
Ayuka Ehara ◽  
Kazuhiko Nakadate ◽  
Kanji Yoshimoto ◽  
Kazutaka Shimoda ◽  
...  
Keyword(s):  
Brain Injury ◽  
Adult Rats ◽  
Male Adult

Gingko biloba Extract (EGb 761) Prevents Increase of Bad-Bcl-XL Interaction Following Cerebral Ischemia

2009 ◽  
Vol 37 (05) ◽  
pp. 867-876 ◽  
Author(s):  
Phil-Ok Koh
Keyword(s):  
Brain Injury ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neuroprotective Effect ◽  
Ischemic Brain Injury ◽  
Egb 761 ◽  
Adult Rats ◽  
Male Adult ◽  
Ischemic Brain ◽  
Gingko Biloba

A standardized extract of Gingko biloba, EGb 761, has been shown to exert a neuroprotective effect against permanent and transient focal cerebral ischemia. This study investigated whether EGb 761 modulates Bcl-2 family proteins in ischemic brain injury. Male adult rats were treated with EGb 761 (100 mg/kg) or vehicle prior to middle cerebral artery occlusion (MCAO), brain tissues were collected 24 hours after MCAO. EGb761 administration significantly decreased the number of TUNEL-positive cells in the cerebral cortex. Ischemic brain injury induced decrease of Bcl-2 and Bcl- X L levels. EGb 761 prevented not only the injury-induced decrease of Bcl-2 and Bcl- X L levels, but also the injury-induced increase of Bax. Moreover, in the presence of EGb 761, the interaction of Bad and Bcl- X L decreased compared to that of vehicle-treated animals. In addition, EGb 761 prevented the injury-induced increase of cleaved PARP. The finding suggests that EGb 761 prevents cell death against ischemic brain injury and EGb 761 neuroprotection is affected by preventing the injury-induced increase of Bad and Bcl- X L interaction.

scholarly journals Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats

2021 ◽  
Vol 219 ◽  
pp. 112323
Author(s):  
Xiang Zhou ◽  
Tongtong Zhang ◽  
Lebin Song ◽  
Yichun Wang ◽  
Qijie Zhang ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Prenatal Exposure ◽  
Adult Rats ◽  
Male Adult ◽  
Butyl Phthalate

Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats

2016 ◽  
Vol 106 ◽  
pp. 46-55 ◽  
Author(s):  
Bassem Sadek ◽  
Ali Saad ◽  
Dhanasekaran Subramanian ◽  
Mohamed Shafiullah ◽  
Dorota Łażewska ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Adult Rats ◽  
Male Adult ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Histamine H3

scholarly journals Astaxanthin reduces ischemic brain injury in adult rats

2009 ◽  
Vol 23 (6) ◽  
pp. 1958-1968 ◽  
Author(s):  
Hui Shen ◽  
Chi-Chung Kuo ◽  
Jenny Chou ◽  
Alice Delvolve ◽  
Shelley N. Jackson ◽  
...  
Keyword(s):  
Brain Injury ◽  
Ischemic Brain Injury ◽  
Adult Rats ◽  
Ischemic Brain

A comparison of different models with motor dysfunction after traumatic brain injury in adult rats

2014 ◽  
Vol 13 (04) ◽  
pp. 579-593 ◽  
Author(s):  
Meng Wang ◽  
Hongjian Pu ◽  
Yingchao Liu ◽  
Zengtao Wang ◽  
Bomin Wang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Motor Dysfunction ◽  
Adult Rats

scholarly journals Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsis

1999 ◽  
Vol 277 (3) ◽  
pp. H1036-H1044 ◽  
Author(s):  
Shaolong Yang ◽  
Mian Zhou ◽  
Douglas J. Koo ◽  
Irshad H. Chaudry ◽  
Ping Wang
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Cardiovascular Response ◽  
Cecal Ligation ◽  
Organ Blood Flow ◽  
Adult Rats ◽  
Male Adult ◽  
Morphological Alterations ◽  
Beneficial Effects ◽  
Renal Oxygen

The cardiovascular response to sepsis includes an early, hyperdynamic phase followed by a late, hypodynamic phase. Although administration of pentoxifylline (PTX) produces beneficial effects in sepsis, it remains unknown whether this agent prevents the transition from the hyperdynamic to the hypodynamic response during the progression of sepsis. To study this, male adult rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP). At 1 h after CLP, PTX (50 mg/kg body wt) or vehicle was infused intravenously over 30 min. At 20 h after CLP (i.e., the late stage of sepsis), cardiac output and organ blood flow were measured by radioactive microspheres. Systemic and regional (i.e., hepatic, intestinal, and renal) oxygen delivery (Do 2) and oxygen consumption (V˙o 2) were determined. Moreover, plasma levels of lactate and alanine aminotransferase (ALT) were measured, and histological examinations were performed. In additional animals, the necrotic cecum was excised at 20 h after CLP, and mortality was monitored for 10 days thereafter. The results indicate that cardiac output, organ blood flow, and systemic and regional Do 2decreased by 36–65% ( P < 0.05) at 20 h after CLP. Administration of PTX early after the onset of sepsis, however, prevented reduction in measured hemodynamic parameters and increased systemic and regional Do 2 andV˙o 2 by 50–264% ( P < 0.05). The elevated levels of lactate (by 173%, P < 0.05) and ALT (by 718%, P < 0.05), as well as the morphological alterations in the liver, small intestine, and kidneys during sepsis were attenuated by PTX treatment. In addition, PTX treatment decreased the mortality rate from 50 to 0% ( P < 0.05) after CLP and cecal excision. Because PTX prevents the occurrence of hypodynamic sepsis, this agent appears to be a useful adjunct for maintaining hemodynamic stability and preventing lethality from sepsis.

Cell Proliferation in the Brains of Adult Rats Exposed to Traumatic Brain Injury

2013 ◽  
pp. 27-38
Author(s):  
Sandra A. Acosta ◽  
Naoki Tajiri ◽  
Paula C. Bickford ◽  
Cesar V. Borlongan
Keyword(s):  
Traumatic Brain Injury ◽  
Cell Proliferation ◽  
Brain Injury ◽  
Adult Rats

Spatial and temporal dynamics of HDACs class IIa following mild traumatic brain injury in adult rats

2022 ◽  
Author(s):  
Swatabdi R. Kamal ◽  
Shreya Potukutchi ◽  
David J. Gelovani ◽  
Robin E. Bonomi ◽  
Srinivasu Kallakuri ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Temporal Dynamics ◽  
Adult Rats ◽  
Spatial And Temporal Dynamics

scholarly journals Differential effects in male adult rats of lifelong coconut oil exposure versus during early-life only

2019 ◽  
Vol 55 ◽  
pp. 17-27 ◽  
Author(s):  
Fernanda Torres Quitete ◽  
Egberto Gaspar de Moura ◽  
Geórgia Correa Atella ◽  
Patricia Cristina Lisboa ◽  
Elaine de Oliveira
Keyword(s):  
Early Life ◽  
Coconut Oil ◽  
Adult Rats ◽  
Male Adult ◽  
Differential Effects ◽  
Oil Exposure
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