Physiologically‐Based Pharmacokinetic Models for
            CYP
            1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam

Hannah Britz; Nina Hanke; Anke‐Katrin Volz; Olav Spigset; Matthias Schwab; Thomas Eissing; Thomas Wendl; Sebastian Frechen; Thorsten Lehr

doi:10.1002/psp4.12397

Physiologically‐Based Pharmacokinetic Models for CYP 1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12397 ◽

2019 ◽

Vol 8 (5) ◽

pp. 296-307 ◽

Cited By ~ 8

Author(s):

Hannah Britz ◽

Nina Hanke ◽

Anke‐Katrin Volz ◽

Olav Spigset ◽

Matthias Schwab ◽

...

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Models ◽

Interaction Prediction ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Cyp 1A2

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Optimization of Drug-Drug Interaction Study Design: Comparison of Minimal Physiologically Based Pharmacokinetic Models on Prediction of CYP3A Inhibition by Ketoconazole

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050732 ◽

2013 ◽

Vol 41 (7) ◽

pp. 1329-1338 ◽

Cited By ~ 24

Author(s):

Bing Han ◽

Jialin Mao ◽

Jenny Y. Chien ◽

Stephen D. Hall

Keyword(s):

Drug Interaction ◽

Study Design ◽

Pharmacokinetic Models ◽

Interaction Study ◽

Drug Interaction Study ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Design Comparison

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Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models

Drug Metabolism and Disposition ◽

10.1124/dmd.120.090928 ◽

2020 ◽

Vol 48 (9) ◽

pp. 769-777 ◽

Cited By ~ 1

Author(s):

Makiko Yamada ◽

Tomoko Ishizuka ◽

Shin-ichi Inoue ◽

Veronika Rozehnal ◽

Thomas Fischer ◽

...

Keyword(s):

Risk Assessment ◽

Drug Interaction ◽

In Vitro Studies ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interaction Potential of Vemurafenib Using R-Value and Physiologically-Based Pharmacokinetic Models

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.06.016 ◽

2021 ◽

Vol 110 (1) ◽

pp. 314-324

Author(s):

Ruhul Kayesh ◽

Taleah Farasyn ◽

Alexandra Crowe ◽

Qiang Liu ◽

Sonia Pahwa ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

R Value ◽

Drug Drug Interaction

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Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction

Clinical Pharmacokinetics ◽

10.1007/s40262-015-0352-5 ◽

2015 ◽

Vol 55 (6) ◽

pp. 735-749 ◽

Cited By ~ 12

Author(s):

Yuan Chen ◽

Fang Ma ◽

Tong Lu ◽

Nageshwar Budha ◽

Jin Yan Jin ◽

...

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic Model ◽

Interaction Prediction ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Cited By ~ 7

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

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Usage of In Vitro Metabolism Data for Drug‐Drug Interaction in Physiologically Based Pharmacokinetic Analysis Submissions to the US Food and Drug Administration

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1819 ◽

2021 ◽

Author(s):

Jieon Lee ◽

Yuching Yang ◽

Xinyuan Zhang ◽

Jianghong Fan ◽

Manuela Grimstein ◽

...

Keyword(s):

Drug Interaction ◽

Drug Administration ◽

Food And Drug Administration ◽

In Vitro Metabolism ◽

Pharmacokinetic Analysis ◽

Physiologically Based Pharmacokinetic ◽

The Us ◽

Physiologically Based ◽

Drug Drug Interaction

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Physiologically Based Pharmacokinetic Modeling of Fimasartan, Amlodipine, and Hydrochlorothiazide for the Investigation of Drug–Drug Interaction Potentials

Pharmaceutical Research ◽

10.1007/s11095-018-2511-5 ◽

2018 ◽

Vol 35 (12) ◽

Author(s):

Su-jin Rhee ◽

Hyun A. Lee ◽

Soyoung Lee ◽

Eunwoo Kim ◽

Inseung Jeon ◽

...

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Interaction Potentials ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Drug Drug Interaction

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Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Cited By ~ 5

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically‐based pharmacokinetic modelling to predict oprozomib CYP3A drug–drug interaction potential in patients with advanced malignancies

British Journal of Clinical Pharmacology ◽

10.1111/bcp.13817 ◽

2018 ◽

Vol 85 (3) ◽

pp. 530-539 ◽

Cited By ~ 1

Author(s):

Ying Ou ◽

Yang Xu ◽

Lia Gore ◽

R. Donald Harvey ◽

Alain Mita ◽

...

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based Pharmacokinetic Modelling ◽

Advanced Malignancies ◽

Physiologically Based ◽

Drug Drug Interaction

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In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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