Peptide sequencing and site-directed mutagenesis identify tyrosine-319 as the active site tyrosine ofEscherichia coli DNA topoisomerase I

1989 ◽  
Vol 6 (3) ◽  
pp. 231-239 ◽  
Author(s):  
Richard M. Lynn ◽  
James C. Wang
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Peptide Sequencing ◽  
Ofescherichia Coli ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Active Site Tyrosine

Effects of Modification of the Active Site Tyrosine of Human DNA Topoisomerase I†

Biochemistry ◽  
2006 ◽  
Vol 45 (27) ◽  
pp. 8402-8410 ◽  
Author(s):  
Rong Gao ◽  
Yi Zhang ◽  
Larisa Dedkova ◽  
Ambar K. Choudhury ◽  
Nicolas J. Rahier ◽  
...  
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Active Site Tyrosine ◽  
Human Dna Topoisomerase I

Analogues of Vaccinia Virus DNA Topoisomerase I Modified at the Active Site Tyrosine

2005 ◽  
Vol 127 (10) ◽  
pp. 3321-3331 ◽  
Author(s):  
Rong Gao ◽  
Yi Zhang ◽  
Ambar K. Choudhury ◽  
Larisa M. Dedkova ◽  
Sidney M. Hecht
Keyword(s):  
Vaccinia Virus ◽  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Active Site Tyrosine

scholarly journals Active Site Mutations in DNA Topoisomerase I Distinguish the Cytotoxic Activities of Camptothecin and the Indolocarbazole, Rebeccamycin

2001 ◽  
Vol 277 (6) ◽  
pp. 3813-3822 ◽  
Author(s):  
Michael H. Woo ◽  
John R. Vance ◽  
Ana R. Otero Marcos ◽  
Christian Bailly ◽  
Mary-Ann Bjornsti
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Cytotoxic Activities ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Active Site Mutations

scholarly journals Site-directed Mutagenesis of Conserved Aspartates, Glutamates and Arginines in the Active Site Region ofEscherichia coliDNA Topoisomerase I

1998 ◽  
Vol 273 (15) ◽  
pp. 8783-8789 ◽  
Author(s):  
Chang-Xi Zhu ◽  
Camille J. Roche ◽  
Nikolaos Papanicolaou ◽  
Anna DiPietrantonio ◽  
Yuk-Ching Tse-Dinh
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Active Site Region

Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison

2007 ◽  
Vol 372 (4) ◽  
pp. 1070-1081 ◽  
Author(s):  
Xiaoping He ◽  
Robert C.A.M. van Waardenburg ◽  
Kerim Babaoglu ◽  
Allen C. Price ◽  
Karin C. Nitiss ◽  
...  
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Active Site Residue ◽  
Dna Topoisomerase

scholarly journals Site-directed Mutagenesis of the Active Site Region in the Quinate/Shikimate 5-Dehydrogenase YdiB ofEscherichia coli

2004 ◽  
Vol 280 (8) ◽  
pp. 7162-7169 ◽  
Author(s):  
Holger A. Lindner ◽  
Guy Nadeau ◽  
Allan Matte ◽  
Gurvan Michel ◽  
Robert Ménard ◽  
...  
Keyword(s):  
Active Site ◽  
Ofescherichia Coli ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Active Site Region

scholarly journals Substitution of Conserved Residues within the Active Site Alters the Cleavage Religation Equilibrium of DNA Topoisomerase I

2004 ◽  
Vol 279 (52) ◽  
pp. 54069-54078 ◽  
Author(s):  
William C. Colley ◽  
Marie van der Merwe ◽  
John R. Vance ◽  
Alex B. Burgin ◽  
Mary-Ann Bjornsti
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Conserved Residues
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