scholarly journals Active Site Mutations in DNA Topoisomerase I Distinguish the Cytotoxic Activities of Camptothecin and the Indolocarbazole, Rebeccamycin

2001 ◽  
Vol 277 (6) ◽  
pp. 3813-3822 ◽  
Author(s):  
Michael H. Woo ◽  
John R. Vance ◽  
Ana R. Otero Marcos ◽  
Christian Bailly ◽  
Mary-Ann Bjornsti
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Cytotoxic Activities ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Active Site Mutations

Mutation of a Conserved Active Site Residue Converts Tyrosyl-DNA Phosphodiesterase I into a DNA Topoisomerase I-dependent Poison

2007 ◽  
Vol 372 (4) ◽  
pp. 1070-1081 ◽  
Author(s):  
Xiaoping He ◽  
Robert C.A.M. van Waardenburg ◽  
Kerim Babaoglu ◽  
Allen C. Price ◽  
Karin C. Nitiss ◽  
...  
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Active Site Residue ◽  
Dna Topoisomerase

scholarly journals Substitution of Conserved Residues within the Active Site Alters the Cleavage Religation Equilibrium of DNA Topoisomerase I

2004 ◽  
Vol 279 (52) ◽  
pp. 54069-54078 ◽  
Author(s):  
William C. Colley ◽  
Marie van der Merwe ◽  
John R. Vance ◽  
Alex B. Burgin ◽  
Mary-Ann Bjornsti
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Conserved Residues

scholarly journals Substitutions of Asn-726 in the Active Site of Yeast DNA Topoisomerase I Define Novel Mechanisms of Stabilizing the Covalent Enzyme-DNA Intermediate

2000 ◽  
Vol 275 (20) ◽  
pp. 15246-15253 ◽  
Author(s):  
Jolanta Fertala ◽  
John R. Vance ◽  
Philippe Pourquier ◽  
Yves Pommier ◽  
Mary-Ann Bjornsti
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase

scholarly journals The C-terminal domain but not the tyrosine 723 of human DNA topoisomerase I active site contributes to kinase activity

1998 ◽  
Vol 26 (12) ◽  
pp. 2963-2970 ◽  
Author(s):  
F. Rossi ◽  
E. Labourier ◽  
I.-e. Gallouzi ◽  
J. Derancourt ◽  
E. Allemand ◽  
...  
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Kinase Activity ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Terminal Domain ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Effects of Modification of the Active Site Tyrosine of Human DNA Topoisomerase I†

Biochemistry ◽  
2006 ◽  
Vol 45 (27) ◽  
pp. 8402-8410 ◽  
Author(s):  
Rong Gao ◽  
Yi Zhang ◽  
Larisa Dedkova ◽  
Ambar K. Choudhury ◽  
Nicolas J. Rahier ◽  
...  
Keyword(s):  
Active Site ◽  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Active Site Tyrosine ◽  
Human Dna Topoisomerase I
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