An efficient Synthesis of Acetylenic ?- and ?-Hydroxy Ketones, ?- and ?-keto acids, and ?- diketones via addition of 1-alkinyllithium compounds to ?- and ?-lactones

1993 ◽  
Vol 335 (5) ◽  
pp. 410-414 ◽  
Author(s):  
Christine Wedler ◽  
Hans Schick
Keyword(s):  
Efficient Synthesis ◽  
Keto Acids ◽  
Hydroxy Ketones

Open Gate of Corynebacterium glutamicum Threonine Deaminase for Efficient Synthesis of Bulky α-Keto Acids

ACS Catalysis ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 9994-10004
Author(s):  
Wei Song ◽  
Xin Xu ◽  
Cong Gao ◽  
Yuxuan Zhang ◽  
Jing Wu ◽  
...  
Keyword(s):  
Corynebacterium Glutamicum ◽  
Efficient Synthesis ◽  
Threonine Deaminase ◽  
Keto Acids

Yttrium triflate-catalyzed addition of lithium enolates to 1,2-epoxides. Efficient synthesis of γ-hydroxy ketones

1994 ◽  
Vol 35 (35) ◽  
pp. 6537-6540 ◽  
Author(s):  
Paolo Crotti ◽  
Valeria Di Bussolo ◽  
Lucilla Favero ◽  
Franco Macchia ◽  
Mauro Pineschi
Keyword(s):  
Efficient Synthesis ◽  
Lithium Enolates ◽  
Hydroxy Ketones

scholarly journals Sustainable synthesis of 3-substituted phthalides via a catalytic one-pot cascade strategy from 2-formylbenzoic acid with β-keto acids in glycerol

2017 ◽  
Vol 13 ◽  
pp. 1425-1429 ◽  
Author(s):  
Lina Jia ◽  
Fuzhong Han
Keyword(s):  
Natural Products ◽  
Cascade Reaction ◽  
Catalytic Process ◽  
Efficient Synthesis ◽  
One Pot ◽  
Keto Acids ◽  
Synthesis Strategy ◽  
Therapeutic Activities

Background: Phthalides are privileged constituents of numerous pharmaceuticals, natural products and agrochemicals and exhibit several biological and therapeutic activities. Therefore, the development of new, facile, and sustainable strategies for the construction of these moieties is highly desired. Results: A broad substrate scope for β-keto acids was found to be strongly compatible with this catalytic process, affording a wide variety of 3-substituted phthalides in good to excellent yields. Conclusion: A concise and efficient synthesis strategy of 3-substituted phthalides from 2-formylbenzoic acid and β-keto acids via a catalytic one-pot cascade reaction in glycerol has been accomplished.

An expedient synthesis of α,α-difluoro-β-hydroxy ketones via decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes

2017 ◽  
Vol 58 (34) ◽  
pp. 3394-3397 ◽  
Author(s):  
Da-Kang Huang ◽  
Zhong-Liang Lei ◽  
Yu-Jun Zhu ◽  
Zhen-Jiang Liu ◽  
Xiao-Jun Hu ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Keto Acids ◽  
Hydroxy Ketones

Efficient synthesis of tertiary α-hydroxy ketones through CO2-promoted regioselective hydration of propargylic alcohols

2014 ◽  
Vol 16 (8) ◽  
pp. 3729-3733 ◽  
Author(s):  
Haitao He ◽  
Chaorong Qi ◽  
Xiaohan Hu ◽  
Yuqi Guan ◽  
Huanfeng Jiang
Keyword(s):  
Efficient Synthesis ◽  
Propargylic Alcohols ◽  
Hydroxy Ketones

A CO2-promoted and silver-catalyzed hydration of propargylic alcohols for the efficient synthesis of α-hydroxy ketones has been developed.

scholarly journals Radical Carbonylative Synthesis of Heterocycles by Visible Light Photoredox Catalysis

Catalysts ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1054
Author(s):  
Xiao-Qiang Hu ◽  
Zi-Kui Liu ◽  
Wen-Jing Xiao
Keyword(s):  
Visible Light ◽  
Efficient Synthesis ◽  
Acyl Radical ◽  
Acyl Chlorides ◽  
Aryl Radicals ◽  
Keto Acids ◽  
Acyl Radicals ◽  
Different Types ◽  
The Impact ◽  
Visible Light Photocatalytic

Visible light photocatalytic radical carbonylation has been established as a robust tool for the efficient synthesis of carbonyl-containing compounds. Acyl radicals serve as the key intermediates in these useful transformations and can be generated from the addition of alkyl or aryl radicals to carbon monoxide (CO) or various acyl radical precursors such as aldehydes, carboxylic acids, anhydrides, acyl chlorides or α-keto acids. In this review, we aim to summarize the impact of visible light-induced acyl radical carbonylation reactions on the synthesis of oxygen and nitrogen heterocycles. The discussion is mainly categorized based on different types of acyl radical precursors.

Sign in / Sign up

Export Citation Format

Share Document