scholarly journals Sustainable synthesis of 3-substituted phthalides via a catalytic one-pot cascade strategy from 2-formylbenzoic acid with β-keto acids in glycerol

2017 ◽  
Vol 13 ◽  
pp. 1425-1429 ◽  
Author(s):  
Lina Jia ◽  
Fuzhong Han
Keyword(s):  
Natural Products ◽  
Cascade Reaction ◽  
Catalytic Process ◽  
Efficient Synthesis ◽  
One Pot ◽  
Keto Acids ◽  
Synthesis Strategy ◽  
Therapeutic Activities

Background: Phthalides are privileged constituents of numerous pharmaceuticals, natural products and agrochemicals and exhibit several biological and therapeutic activities. Therefore, the development of new, facile, and sustainable strategies for the construction of these moieties is highly desired. Results: A broad substrate scope for β-keto acids was found to be strongly compatible with this catalytic process, affording a wide variety of 3-substituted phthalides in good to excellent yields. Conclusion: A concise and efficient synthesis strategy of 3-substituted phthalides from 2-formylbenzoic acid and β-keto acids via a catalytic one-pot cascade reaction in glycerol has been accomplished.

New efficient synthesis of benzofuro[2,3-b]pyrroles utilizing a reactive nitrilium trapping approach by an acid-promoted cascade addition/cyclization sequence

2020 ◽  
Vol 44 (9) ◽  
pp. 3632-3636
Author(s):  
Sandip Gangadhar Balwe ◽  
Yeon Tae Jeong
Keyword(s):  
Cascade Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
Highly Efficient

The first p-TSA·H2O-catalyzed highly efficient one-pot cascade reaction for the synthesis of novel fused tricyclic benzofuro[2,3-b]pyrroles has been discovered.

Visible-Light Photoredox-Catalyzed Cascade Reaction for the Synthesis of Pyrrolo[2,1-a]isoquinoline-Substituted Phosphonates

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 522-529 ◽  
Author(s):  
Deqing Shi ◽  
Lingna Wang ◽  
Tiancong Ma ◽  
Mingming Qiao ◽  
Qiangxian Wu ◽  
...  
Keyword(s):  
Visible Light ◽  
Visible Light Irradiation ◽  
Room Temperature ◽  
Cascade Reaction ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Oxidative Aromatization ◽  
Activated Olefins ◽  
Catalyzed Oxidation

A visible-light photoredox-catalyzed oxidation/[3+2] cycloaddition/oxidative aromatization cascade reaction of [(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phosphonates and activated olefins or alkynes for the efficient synthesis of potentially biological active pyrrolo[2,1-a]isoquinoline-substituted phosphonates was developed. This transformation features mild reaction conditions (i.e., visible light irradiation, room temperature), molecular oxygen (O2) as a green oxidant, simple ‘one-pot’ operation.

Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp3)–H functionalization of 2-alkylazaarenes

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103091-103094 ◽  
Author(s):  
Santosh S. Chavan ◽  
Mohsinkhan Y. Pathan ◽  
Shafeek A. R. Mulla
Keyword(s):  
Michael Addition ◽  
Cascade Reaction ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
One Pot

A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the efficient synthesis of β-azaarene substituted ketones via an aldol–Michael addition/C(sp3)–H functionalization of 2-alkylazaarenes has been developed.

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

scholarly journals Gold(I)-Catalyzed Domino Reaction for Furopyrans Synthesis

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4976
Author(s):  
Marie Ruch ◽  
Nicolas Brach ◽  
Roméric Galéa ◽  
Patrick Wagner ◽  
Gaëlle Blond
Keyword(s):  
Cascade Reaction ◽  
Diels Alder ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
Quaternary Center ◽  
Stereogenic Centers

We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center are formed.

Novel and efficient synthesis of fused spiro piperidone-cyclopropanes from cascade reaction of 1-acylcyclopropanecarboxamides and polarized olefin

2021 ◽  
Author(s):  
Xiao Dan Han ◽  
Gao Liang Peng ◽  
Hui Bin Wang ◽  
lei wu ◽  
Jian Ping Fu ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Single Step ◽  
Efficient Synthesis ◽  
One Pot ◽  
The One ◽  
Cyclopropane Derivatives

We report here that a series of O-bridged ring fused spiro piperidone-cyclopropane derivatives 3 can be constructed in a single step by the one-pot reaction of 1-acylcyclopropanecarboxamides 1 with polarized...

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