Synthesis of chitosan-based thermo- and pH-responsive porous nanoparticles by temperature-dependent self-assembly method and their application in drug release

2009 ◽  
Vol 47 (19) ◽  
pp. 5126-5136 ◽  
Author(s):  
Chung-Yang Chuang ◽  
Trong-Ming Don ◽  
Wen-Yen Chiu
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Ph Responsive ◽  
Temperature Dependent ◽  
Assembly Method ◽  
Porous Nanoparticles

scholarly journals Carbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Release

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1208
Author(s):  
Narsimha Mamidi ◽  
Ramiro Velasco Delgadillo ◽  
Aldo Gonzáles Ortiz ◽  
Enrique Barrera
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Drug Release ◽  
Self Assembly ◽  
Critical Role ◽  
Layer By Layer ◽  
Film System ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Thin Film System

Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular π-π stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 ± 8.2 MPa of the tensile strength (σult), 43.2 ± 1.1 GPa of Young’s modulus (E), and 164.5 ± 1.7 Jg−1 of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.

Construction of multilayer films with bactericidal and long-term antitumor drug release properties as a non-vascular stent coating for therapy in obstruction

2019 ◽  
Vol 7 (32) ◽  
pp. 4963-4972 ◽  
Author(s):  
Xiao-yan Xu ◽  
Yan-fang Chen ◽  
Qing-gang Tan ◽  
Zhi-jie Chen ◽  
Yan Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Multilayer Films ◽  
Antitumor Drug ◽  
Layer By Layer ◽  
Vascular Stent ◽  
Assembly Method ◽  
Stent Coating

An antibacterial and antitumor coating for non-vascular stent was constructed via the layer-by-layer electrostatic self-assembly method.

Synthesis, self-assembly and drug release behaviors of pH-responsive copolymers ethyl cellulose-graft-PDEAEMA through ATRP

2011 ◽  
Vol 84 (1) ◽  
pp. 195-202 ◽  
Author(s):  
Deqian Wang ◽  
Junjun Tan ◽  
Hongliang Kang ◽  
Lin Ma ◽  
Xin Jin ◽  
...  
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Ethyl Cellulose ◽  
Ph Responsive

Synthesis, self-assembly, and pH-responsive drug release of PHMEMA-PEG-PHMEMA ABA triblock copolymers

2018 ◽  
Vol 55 (10) ◽  
pp. 691-697 ◽  
Author(s):  
Qingqing Pan ◽  
Zhihui Zong ◽  
Jingyi Shen ◽  
Hongbao Xue ◽  
Yuji Pu
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Ph Responsive

scholarly journals Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 346 ◽  
Author(s):  
Ana Barbosa ◽  
Sofia Costa Lima ◽  
Salette Reis
Keyword(s):  
Antioxidant Activity ◽  
Particle Size ◽  
Self Assembly ◽  
Functional Food ◽  
Polymeric Nanoparticles ◽  
Chitosan Nanoparticles ◽  
Weight Ratio ◽  
Ph Responsive ◽  
Assembly Method ◽  
Nm Range

Polymeric nanoparticles based on fucoidan and chitosan were developed to deliver quercetin as a novel functional food. Through the polyelectrolyte self-assembly method, fucoidan/chitosan (F/C) nanoparticles were obtained with three different weight ratios (1/1, 3/1, and 5/1). The content of quercetin in the fucoidan/chitosan nanoparticles was in the range 110 ± 3 to 335 ± 4 mg·mL−1, with the increase of weight ratio of fucoidan to chitosan in the nanoparticle. Physicochemically stable nanoparticles were obtained with a particle size within the 300–400 nm range and surface potential higher than +30 mV for the 1F/1C ratio nanoparticle and around −30 mV for the 3F/1C and 5F/1C ratios nanoparticles. The 1F/1C ratio nanoparticle became larger and more unstable as the pH increased from 2.5 to 7.4, while the 3F/1C and 5F/1C nanoparticles retained their initial characteristics. This result indicates that the latter nanoparticles were stable along the gastrointestinal tract. The quercetin-loaded fucoidan/chitosan nanoparticles showed strong antioxidant activity and controlled release under simulated gastrointestinal environments (in particular for the 3F/1C and 5F/1C ratios), preventing quercetin degradation and increasing its oral bioavailability.

scholarly journals Cationic amphiphilic drugs self-assemble to the core–shell interface of PEGylated phospholipid micelles and stabilize micellar structure

2013 ◽  
Vol 371 (2000) ◽  
pp. 20120309 ◽  
Author(s):  
Jing Wang ◽  
Xueqing Xing ◽  
Xiaocui Fang ◽  
Chang Zhou ◽  
Feng Huang ◽  
...  
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Preparation Method ◽  
Assembly Method ◽  
Phospholipid Micelles ◽  
Cationic Amphiphilic Drugs ◽  
Assembly Mechanism ◽  
Amphiphilic Drugs ◽  
Series Of Experiments

Since polymeric micelles are promising and have potential in drug delivery systems, people have become more interested in studying the compatibility of polymeric carriers and drugs, which might help them to simplify the preparation method and increase the micellar stability. In this article, we report that cationic amphiphilic drugs can be easily encapsulated into PEGylated phospholipid (PEG–PE) micelles by self-assembly method and that they show high encapsulation efficiency, controllable drug release and better micellar stability than empty micelles. The representative drugs are doxorubicin and vinorelbine. However, gemcitabine and topotecan are not suitable for PEG–PE micelles due to lack of positive charge or hydrophobicity. Using a series of experiments and molecular modelling, we figured out the assembly mechanism, structure and stability of drug-loaded micelles, and the location of drugs in micelles. Integrating the above information, we explain the effect of the predominant force between drugs and polymers on the assembly mechanism and drug release behaviour. Furthermore, we discuss the importance of p K a and to evaluate the compatibility of drugs with PEG–PE in self-assembly preparation method. In summary, this work provides a scientific understanding for the reasonable designing of PEG–PE micelle-based drug encapsulation and might enlighten the future study on drug–polymer compatibility for other polymeric micelles.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document