scholarly journals Polypharmacy and the risk of drug–drug interactions and potentially inappropriate medications in hospital psychiatry

2021 ◽  
Author(s):  
Jan Wolff ◽  
Gudrun Hefner ◽  
Claus Normann ◽  
Klaus Kaier ◽  
Harald Binder ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Potentially Inappropriate Medications ◽  
Inappropriate Medications ◽  
Hospital Psychiatry

Vigilance of Drug-Drug interactions to Mitigate ADRs: Front and Center for Pharmacists

2020 ◽  
Vol 35 (8) ◽  
pp. 336-337
Author(s):  
Manju T Beier
Keyword(s):  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Potentially Inappropriate Medications ◽  
Drug Reactions ◽  
Inappropriate Medications

As the number of people taking multiple medications increases, differing approaches to address drug-drug interactions and adverse drug reactions have been debated—but not solved—despite excellent criteria to stop the use of potentially inappropriate medications.

scholarly journals Drug therapy, potential interactions and iatrogenesis as factors related to frailty in the elderly

2018 ◽  
Vol 21 (5) ◽  
pp. 588-596 ◽  
Author(s):  
Andressa Rodrigues Pagno ◽  
Carolina Baldissera Gross ◽  
Daiana Meggiolaro Gewehr ◽  
Christiane de Fátima Colet ◽  
Evelise Moraes Berlezi
Keyword(s):  
Drug Therapy ◽  
Drug Interactions ◽  
Inappropriate Medication ◽  
The Elderly ◽  
Potentially Inappropriate Medication ◽  
Potentially Inappropriate Medications ◽  
Elderly Persons ◽  
Potential Drug ◽  
Increased Risk ◽  
Inappropriate Medications

Abstract Objective: to investigate the use of drugs, potential drug interactions and iatrogenesis, as factors associated with frailty. Method: an observational, cross-sectional, population-based study of elderly persons registered with the Family Health Strategies of the urban area of a municipal region in the south of Brazil was carried out. The sample was probabilistic and involved 554 elderly persons; and the proportional stratified sampling technique by FHS and gender was used. Data collection was performed in the home, with the gathering of information regarding sociodemographic characteristics and pharmacotherapeutic profile and the evaluation of frailty based on Fried et al. (2001). Results: medications were taken by 86.3% of the elderly and there was a prevalence of frailty of 63.0%. A total of 39.4% of the elderly were exposed to polypharmacy, 49.1% used potentially inappropriate medications and 52.2% were exposed to potential drug interactions, the most frequent being enalapril and metformin. An association between increased risk of frailty and the variables: polypharmacy; use of potentially inappropriate medications; potential drug interactions; more than two potential drug interactions with the presence or absence of potentially inappropriate medication was identified. Conclusion: an association was found between frailty and polypharmacy, the use of potentially inappropriate medication and the presence of drug interactions. The findings underscore the importance of the monitoring of drug therapy in this population group with a view to the early detection, prevention and resolution of iatrogenesis arising from the use of medicines.

scholarly journals Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

2018 ◽  
Vol 21 (2) ◽  
pp. 164-175
Author(s):  
Daniela Santos Tavares ◽  
Nayara Cândida Gomes ◽  
Leiner Resende Rodriguês ◽  
Darlene Mara dos Santos Tavares
Keyword(s):  
Metabolic Syndrome ◽  
Drug Interactions ◽  
Elderly People ◽  
Potentially Inappropriate Medications ◽  
Elderly Persons ◽  
Factors Associated ◽  
Chi Squared ◽  
Treatment Use ◽  
Age Range ◽  
Inappropriate Medications

Abstract Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis (p<0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range (p=0.005), polypharmacy (p<0.001) and use of potentially inappropriate medications (p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.

scholarly journals Drug-drug interactions and potentially inappropriate medications among elderly outpatients

2021 ◽  
Vol 57 ◽  
Author(s):  
Atrianfar Fatemeh ◽  
Rezaei Fatemeh ◽  
Heidari Kazem ◽  
Kargar Mona ◽  
Javadi Mohammad Reza ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Potentially Inappropriate Medications ◽  
Elderly Outpatients ◽  
Inappropriate Medications
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