scholarly journals POTENTIALLY INAPPROPRIATE MEDICATIONS AND DRUG-DRUG INTERACTIONS IN ELDERLY PATIENTS WITH MENTAL ILLNESS

2021 ◽  
pp. 34-34
Author(s):  
O.O. Kirilochev ◽  
V.S. Tarkhanov
Keyword(s):  
Mental Illness ◽  
Elderly Patients ◽  
Drug Interactions ◽  
Potentially Inappropriate Medications ◽  
Inappropriate Medications

scholarly journals Drug–Drug Interactions in Elderly Patients with Potentially Inappropriate Medications in Primary Care, Nursing Home and Hospital Settings: A Systematic Review and a Preliminary Study

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 266
Author(s):  
Mathilde Bories ◽  
Guillaume Bouzillé ◽  
Marc Cuggia ◽  
Pascal Le Corre
Keyword(s):  
Systematic Review ◽  
Primary Care ◽  
Nursing Home ◽  
Elderly Patients ◽  
Drug Interactions ◽  
Hospital Setting ◽  
Potentially Inappropriate Medications ◽  
Inappropriate Medications ◽  
Care Nursing ◽  
Primary Care Nursing

Drug–drug interactions (DDI) occurring with potentially inappropriate medications (PIM) are additional risk factors that may increase the inappropriate character of PIM. The aim of this study was (1) to describe the prevalence and severity of DDI in patients with PIM and (2) to evaluate the DDI specifically regarding PIM. This systematic review is based on a search carried out on PubMed and Web-of-Science from inception to June 30, 2020. We extracted data of original studies that assessed the prevalence of both DDI and PIM in elderly patients in primary care, nursing home and hospital settings. Four hundred and forty unique studies were identified: 91 were included in the qualitative analysis and 66 were included in the quantitative analysis. The prevalence of PIM in primary care, nursing home and hospital were 19.1% (95% confidence intervals (CI): 15.1–23.0%), 29.7% (95% CI: 27.8–31.6%) and 44.6% (95% CI: 28.3–60.9%), respectively. Clinically significant severe risk-rated DDI averaged 28.9% (95% CI: 17.2–40.6), in a hospital setting; and were approximately 7-to-9 lower in primary care and nursing home, respectively. Surprisingly, only four of these studies investigated DDI involving specifically PIM. Hence, given the high prevalence of severe DDI in patients with PIM, further investigations should be carried out on DDI involving specifically PIM which may increase their inappropriate character, and the risk of adverse drug reactions.

scholarly journals Prevalence of potentially inappropriate medications at admission and discharge among hospitalised elderly patients with acute medical illness at a single centre in Japan: a retrospective cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021152 ◽  
Author(s):  
Junpei Komagamine
Keyword(s):  
Elderly Patients ◽  
Cross Sectional Study ◽  
Medical Illness ◽  
Potentially Inappropriate Medications ◽  
Sectional Study ◽  
Single Centre ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Hospitalised Patients ◽  
Inappropriate Medications

ObjectiveTo determine the prevalence of potentially inappropriate medications (PIMs) at admission and discharge among hospitalised elderly patients with acute medical illness in Japan.DesignA retrospective single-centre cross-sectional study.ParticipantsHospitalised patients aged 65 years or older admitted for pneumonia, heart failure, ischaemic stroke, acute coronary syndrome, chronic obstructive pulmonary disease or asthma, gastrointestinal bleeding, urinary tract infection or epilepsy from September 2014 to June 2016 who were still alive at discharge.Main outcome measuresThe primary outcome was the proportion of patients taking at least one PIM at admission and discharge. PIMs were defined based on the 2015 American Geriatric Society Beers Criteria. Temporal changes in the proportion of patients taking at least one PIM from admission to discharge were also evaluated.ResultsDuring the study period, 689 eligible patients were identified. The median patient age was 82.0 years (IQR 76.0–88.0), 348 (50.5%) were men and the median number of medications at admission was 5.0 (IQR 3.0–8.0). The proportions of patients taking any PIMs at admission and discharge were 47.9% (95% CI 44.2% to 51.6%) and 25.1% (95% CI 21.9% to 28.4%), respectively. The proportion of patients taking any PIMs was significantly lower at discharge than at admission (reduction rate 0.48, 95%, CI 0.41 to 0.53).ConclusionsA substantial proportion of hospitalised elderly patients with acute medical illness took PIMs at admission and discharge. These findings should be confirmed at other hospitals in Japan.

Vigilance of Drug-Drug interactions to Mitigate ADRs: Front and Center for Pharmacists

2020 ◽  
Vol 35 (8) ◽  
pp. 336-337
Author(s):  
Manju T Beier
Keyword(s):  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Potentially Inappropriate Medications ◽  
Drug Reactions ◽  
Inappropriate Medications

As the number of people taking multiple medications increases, differing approaches to address drug-drug interactions and adverse drug reactions have been debated—but not solved—despite excellent criteria to stop the use of potentially inappropriate medications.

Potentially inappropriate medications in elderly patients with heart failure: Beers Criteria‐based study

2020 ◽  
Vol 28 (6) ◽  
pp. 652-659 ◽  
Author(s):  
Mariam Zahwe ◽  
Hadi Skouri ◽  
Samar Rachidi ◽  
Maurice Khoury ◽  
Samar Noureddine ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
Beers Criteria ◽  
Potentially Inappropriate Medications ◽  
Patients With Heart Failure ◽  
Inappropriate Medications

A Closer Look at the 2015 Beers Criteria

2016 ◽  
Vol 30 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Rebecca L. Salbu ◽  
Judith Feuer
Keyword(s):  
Elderly Patients ◽  
Health Care Providers ◽  
Clinical Judgment ◽  
The Elderly ◽  
Specific Information ◽  
Beers Criteria ◽  
Potentially Inappropriate Medications ◽  
Care Providers ◽  
Inappropriate Medications ◽  
Made In

The Beers Criteria identifies potentially inappropriate medications for patients who are 65 years of age and older. Initially published in 1991, the criteria have been updated multiple times, most recently in 2015. The Beers Criteria is a tool designed to alert health-care providers to the potential harms of specific medications so they may better tailor therapeutic regimens for their elderly patients. The expert panel of the 2015 update made changes to a number of previous recommendations and provided 2 new tables on select drug interactions and select medications requiring renal dose adjustments. The purpose of this review is to provide additional details and rationale behind selected noteworthy changes within the 2015 criteria. Specific information is provided on the changes in recommendations for the use of nitrofurantoin, antiarrhythmics, nonbenzodiazepine receptor agonist hypnotics, antipsychotics, and proton pump inhibitors in the elderly. Additional comparisons are made between the 2012 recommendations and newer recommendations made in the 2015 update, along with rationale for the change. This review will allow practitioners to apply the 2015 Beers Criteria and integrate their clinical judgment when evaluating and selecting drug therapy for elderly patients.

scholarly journals Inappropriate prescribing in hospitalized elderly patients

2017 ◽  
Vol 6 (4) ◽  
pp. 701
Author(s):  
Lina K. Massoud ◽  
Hala Z. AlAgha ◽  
Mahmoud H. Taleb
Keyword(s):  
Elderly Patients ◽  
Elderly People ◽  
Inappropriate Prescribing ◽  
The Elderly ◽  
Potentially Inappropriate Medications ◽  
Hospitalized Elderly ◽  
Different Types ◽  
Elderly Inpatients ◽  
Hospitalized Elderly Patients ◽  
Inappropriate Medications

Inappropriate prescribing (IP) is a major healthcare problem in elderly patients. The risk of this problem increases during hospitalization. This is due to increase morbidity and thus increases the use of medications by the inpatients. This study will clarify the problem of IP for elderly people during hospitalization and will identify the different types of it. It also will highlight some tools that are used to assess the different types of IP and the prevalence of it in elderly patients during hospitalization. Finally, the study will address the consequences of IP in the elderly inpatients and the risks associated with the use of some potentially inappropriate medications (PIMs) in the elderly. 

Sign in / Sign up

Export Citation Format

Share Document