scholarly journals Polypharmacy, Drug-Drug Interactions, and Potentially Inappropriate Medications in Older Adults with Human Immunodeficiency Virus Infection

2014 ◽  
Vol 62 (3) ◽  
pp. 447-453 ◽  
Author(s):  
Meredith Greene ◽  
Michael A. Steinman ◽  
Ian R. McNicholl ◽  
Victor Valcour
Keyword(s):  
Older Adults ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Drug Interactions ◽  
Potentially Inappropriate Medications ◽  
Immunodeficiency Virus ◽  
Inappropriate Medications

scholarly journals Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population

2016 ◽  
Vol Volume 11 ◽  
pp. 1149-1157 ◽  
Author(s):  
Mercedes Gimeno-Gracia ◽  
Maria Jose Crusells-Canales ◽  
Francisco Javier Armesto-Gomez ◽  
Vicente Compaired-Turlan ◽  
Maria Jose Rabanaque-Hernandez
Keyword(s):  
Older Adults ◽  
Human Immunodeficiency Virus ◽  
General Population ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus

scholarly journals Clarithromycin lowers plasma zidovudine levels in persons with human immunodeficiency virus infection.

1997 ◽  
Vol 41 (8) ◽  
pp. 1709-1714 ◽  
Author(s):  
M A Polis ◽  
S C Piscitelli ◽  
S Vogel ◽  
F G Witebsky ◽  
P S Conville ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Drug Interactions ◽  
Maximum Concentration ◽  
Opportunistic Infections ◽  
Simultaneous Administration ◽  
Time Curve ◽  
Antiretroviral Agents ◽  
Immunodeficiency Virus

The use of antiretroviral agents and drugs for the treatment and prophylaxis of opportunistic infections has lengthened the survival of persons with AIDS. In the era of multidrug therapy, drug interactions are important considerations in designing effective and tolerable regimens. Clarithromycin has had a significant impact on the treatment of disseminated Mycobacterium avium complex infection, and zidovudine is the best-studied and one of the most widely used antiretroviral agents in this population. We conducted a study to determine the maximally tolerated dose of clarithromycin and the pharmacokinetics of clarithromycin and zidovudine individually and in combination. Mixing studies were conducted to simulate potential interaction in the gastric environment. The simultaneous administration of zidovudine and clarithromycin had little impact on the pharmacokinetics of clarithromycin or of its major metabolite. However, coadministration of zidovudine and clarithromycin at three doses (500 mg orally [p.o.] twice daily [b.i.d.], 1,000 mg p.o. b.i.d., and 2,000 mg p.o. b.i.d.) reduced the maximum concentration of zidovudine by 41% (P < 0.005) and the area under the concentration-time curve from 0 to 4 h for zidovudine by 25% (P < 0.05) and increased the time to maximum concentration of zidovudine by 84% (P < 0.05), compared with zidovudine administered alone. Mixing studies did not detect the formation of insoluble complexes due to chelation, suggesting that the decrease in zidovudine concentrations results from some other mechanism. Simultaneous administration of zidovudine and clarithromycin appears to decrease the levels of zidovudine in serum, and it may be advisable that these drugs not be given at the same time. Drug interactions should be carefully evaluated in persons with advanced human immunodeficiency virus infection who are receiving multiple pharmacologic agents.

PS-022 Polypharmacy and drug-drug interactions in adults with human immunodeficiency virus infection

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A144.2-A145
Author(s):  
P Lopez-Sanchez ◽  
JM Martínez-Sesmero ◽  
AR Rubio Salvador ◽  
M García Palomo ◽  
P Moya-Gomez
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Drug Interactions ◽  
Immunodeficiency Virus

scholarly journals Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection

2013 ◽  
Vol 115 (4) ◽  
pp. 505-514 ◽  
Author(s):  
Mahnaz Fatahzadeh ◽  
Nicolas F. Schlecht ◽  
Zigui Chen ◽  
Danielle Bottalico ◽  
Sharod McKinney ◽  
...  
Keyword(s):  
Older Adults ◽  
Human Immunodeficiency Virus ◽  
Human Papillomavirus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus

Rapid diameter expansion of aortic aneurysm after human immunodeficiency virus infection

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 387-390
Author(s):  
Thomas Kotsis ◽  
Louizos-Alexandros Louizos ◽  
Spyridon Mylonas ◽  
Evangelos Pappas ◽  
Karandrea Despoina ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Aortic Aneurysm ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Immunodeficiency Virus
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