scholarly journals Enhancing case ascertainment of Parkinson's disease using Medicare claims data in a population-based cohort: the Cardiovascular Health Study

2013 ◽  
Vol 23 (2) ◽  
pp. 119-127 ◽  
Author(s):  
Thanh G. N. Ton ◽  
Mary Lou Biggs ◽  
Diane Comer ◽  
Lesley Curtis ◽  
Shu-Ching Hu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Claims Data ◽  
Population Based ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Medicare Claims ◽  
Case Ascertainment ◽  
Medicare Claims Data

CONCURRENCE OF FRAILTY AND PARKINSON’S DISEASE

2012 ◽  
pp. 1-5
Author(s):  
K.P. ROLAND ◽  
K.M.D. CORNETT ◽  
O. THEOU ◽  
J.M. JAKOBI ◽  
G.R. JONES
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Levodopa Dose ◽  
Frailty Phenotype ◽  
Age Related

Background: Females with Parkinson’s disease (PD) are at greater risk of frailty than males. Little is known about how age and disease-related characteristics influence frailty in females with PD because frailty studies often exclude persons with underlying neurological pathologies. Objective: To determine age and diseaserelated characteristics that best explain physical frailty in community-dwelling females with and without PD. Design & Measurement: Correlation coefficients described relationships between PD-related characteristics and physical frailty phenotype criteria (Cardiovascular Health Study). Regression analysis identified associations between disease-related characteristics and frailty in non-PD and PD females. Setting: Community-dwelling. Participants: Females with mild to moderate PD (n = 17, mean age = 66 ± 8.5 years) and non-PD (n = 18, mean age = 72 ± 13.2 years) participated. Results: Daily carbidopa-levodopa dose best explained frailty in PD females (β = 0.5), whereas in non-PD females, age (β = 0.7) and comorbidity (β = 0.5) were most associated with frailty. Conclusions: Dopaminergic medication explained frailty in PD and not measures of disease progression (i.e. severity, duration). In females without PD age-related accumulation of comorbidities resulted in greater risk of frailty. This indicates dopaminergic management of PD symptoms may better reflect frailty in females with PD than disease severity or duration. These data suggest the influence of underlying frailty should be considered when managing neurological conditions. Understanding how frailty concurrently exists with PD and how these conditions progress within the aging female will facilitate future care management.

scholarly journals Post Hoc Parkinson’s Disease: Identifying an Uncommon Disease in the Cardiovascular Health Study

2010 ◽  
Vol 35 (4) ◽  
pp. 241-249 ◽  
Author(s):  
T.G. Ton ◽  
S. Jain ◽  
R. Boudreau ◽  
E.L. Thacker ◽  
E.S. Strotmeyer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Uncommon Disease ◽  
Post Hoc

scholarly journals Markers of inflammation in prevalent and incident Parkinson’s disease in the Cardiovascular Health Study

2012 ◽  
Vol 18 (3) ◽  
pp. 274-278 ◽  
Author(s):  
Thanh G.N. Ton ◽  
Samay Jain ◽  
Mary L. Biggs ◽  
Evan L. Thacker ◽  
Elsa S. Strotmeyer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Markers Of Inflammation

scholarly journals Competing risk of mortality in association studies of non-fatal events

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255313
Author(s):  
Petra Buzkova
Keyword(s):  
Cardiovascular Health ◽  
Association Studies ◽  
Population Based ◽  
Competing Risk ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Subdistribution Hazard ◽  
Hazard Regression ◽  
Risk Of Mortality

In geriatric research of non-fatal events, participants often die during the study follow-up without having the non-fatal event of interest. Cause-specific (CS) hazard regression and Fine-Gray (FG) subdistribution hazard regression are the two most common estimation approaches addressing such competing risk. We explain how the conventional CS approach and the FG approach differ and why many FG estimates of associations are counter-intuitive. Additionally, we clarify the indirect link between models for hazard and models for cumulative incidence. The methodologies are contrasted on data from the Cardiovascular Health Study, a population-based study in adults aged 65 years and older.

Abstract P353: Paradoxical Secular Trends in Stroke and Hypertension Incidences among Men and Women in Rural Areas of China: Results from Two Population-based Cohorts

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Liqiang Zheng ◽  
Yingxian Sun
Keyword(s):  
Rural Areas ◽  
Cardiovascular Health ◽  
Reference Group ◽  
Population Based ◽  
Secular Trends ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Chinese Adults ◽  
Men And Women ◽  
Adjusted Incidence

Background: Stroke has been the leading cause of death in China and hypertension accounts for about one-third of deaths due to stroke in Chinese adults. The current study aimed to examine the secular trends of stroke and hypertension in two population-based samples. Methods: The study included three cohorts (2004-2008, n=38,949; 2008-2010, n=38,264; and 2013-2016, n=8,880) from two population-based studies: Fuxin Cardiovascular Cohort Study (FCCS) and Northeast China Rural Cardiovascular Health Study (NCRCHS). Results: There was a significant increasing trend for incidence of stroke in both men and women ( P for trend <0.001). The age-adjusted incidence of stroke (per 100,000 person-years) among the 3 Cohorts was 575.3, 893.0, and 1382.7 in men and 358.9, 456.5, and 1046.2 in women, respectively. With the 2004 Cohort as the reference group, we observed a 52.9% increase in 2008-2010 and a 169.9% increase in 2013-2016 among men. However, hypertension incidence decreased steeply in both sexes from 2004-2008 (15.2 in men and 12.6 in women per 100 person-years) to 2013-2016 (9.6 in men and 7.1 in women per 100 person-years) ( P for trend <0.0001). Conclusions: Incidence of stroke has increased and incidence of hypertension decreased since 2004, which has implications for prevention of both diseases in China.

scholarly journals Risk Factors for Incident Carotid Artery Revascularization among Older Adults: The Cardiovascular Health Study

2016 ◽  
Vol 6 (3) ◽  
pp. 129-139 ◽  
Author(s):  
Parveen K. Garg ◽  
Willam J.H. Koh ◽  
Joseph A. Delaney ◽  
Ethan A. Halm ◽  
Calvin H. Hirsch ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Carotid Artery ◽  
Cardiovascular Health ◽  
Multivariable Analysis ◽  
Population Based ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Increased Risk

Background: Population-based risk factors for carotid artery revascularization are not known. We investigated the association between demographic and clinical characteristics and incident carotid artery revascularization in a cohort of older adults. Methods: Among Cardiovascular Health Study participants, a population-based cohort of 5,888 adults aged 65 years or older enrolled in two waves (1989-1990 and 1992-1993), 5,107 participants without a prior history of carotid endarterectomy (CEA) or cerebrovascular disease had a carotid ultrasound at baseline and were included in these analyses. Cox proportional hazards multivariable analysis was used to determine independent risk factors for incident carotid artery revascularization. Results: Over a mean follow-up of 13.5 years, 141 participants underwent carotid artery revascularization, 97% were CEA. Baseline degree of stenosis and incident ischemic cerebral events occurring during follow-up were the strongest predictors of incident revascularization. After adjustment for these, factors independently associated with an increased risk of incident revascularization were: hypertension (HR 1.53; 95% CI: 1.05-2.23), peripheral arterial disease (HR 2.57; 95% CI: 1.34-4.93), and low-density lipoprotein cholesterol (HR 1.23 per standard deviation [SD] increment [35.4 mg/dL]; 95% CI: 1.04-1.46). Factors independently associated with a lower risk of incident revascularization were: female gender (HR 0.51; 95% CI: 0.34-0.77) and older age (HR 0.69 per SD increment [5.5 years]; 95% CI: 0.56-0.86). Conclusions: Even after accounting for carotid stenosis and incident cerebral ischemic events, carotid revascularization is related to age, gender, and cardiovascular risk factors. Further study of these demographic disparities and the role of risk factor control is warranted.

Abstract MP07: Racial Differences in Incident CHD in Observational Population-based Studies

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Lisandro D Colantonio ◽  
Christopher M Gamboa ◽  
Joshua S Richman ◽  
Emily B Levitan ◽  
Elsayed Z Soliman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Black Men ◽  
Racial Differences ◽  
Cardiovascular Health ◽  
White Men ◽  
Population Based ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Adjusted Risk ◽  
Similar Risk

Background: In the modern era, black men have twice the risk for fatal CHD versus white men, with similar incidence of total CHD. To examine secular trends in these findings, we compared the risk for incident fatal, nonfatal and total CHD by race across three US cohorts from different time periods. Methods: We analyzed data from blacks and whites in the Atherosclerosis Risk In Communities (ARIC) study (n=14,967, all 45-64 years of age, baseline 1987-1989), the Cardiovascular Health Study (CHS, n=4,626, all ≥65 years of age, baseline 1989-1993) and the REasons for Geographic and Racial Differences in Stroke (REGARDS) study (13,115 participants 45-64 years of age, 7,493 participants ≥65 years of age, baseline 2003-2007) who were free of CHD at baseline. Participants were followed for up to 10 years for fatal or nonfatal CHD. Analyses were stratified by age and gender and adjusted for similar risk factors across cohorts. Results: After age adjustment, black men 45-64 years of age in ARIC and REGARDS had higher risk for fatal CHD and similar risk for nonfatal and total CHD compared with their white counterparts (Table). After further adjustment for risk factors, blacks had similar risk for fatal CHD and lower risk for nonfatal and total CHD. A higher age-adjusted risk for fatal CHD and lower multivariable-adjusted risk for nonfatal CHD was also found among black versus white men ≥65 years of age in REGARDS; however, these associations were attenuated/absent in CHS. Among women 45-64 years of age in ARIC and REGARDS, blacks had higher age-adjusted risk for fatal, nonfatal and total CHD which were attenuated after adjustment for risk factors. There was no association between black race and CHD among women ≥65 years of age. Conclusion: Black-white disparities in the incidence of fatal CHD have remained similar for many years, particularly among those <65 years of age, and are explained by risk factors. The higher risk for fatal CHD is more striking among black men who consistently shown similar risk for total CHD compared with white men across cohorts.

The Sensitivity of Medicare Claims Data for Case Ascertainment of Six Common Cancers

Medical Care ◽  
1999 ◽  
Vol 37 (5) ◽  
pp. 436-444 ◽  
Author(s):  
Gregory S. Cooper ◽  
Zhong Yuan ◽  
Kurt C. Stange ◽  
Leslie K. Dennis ◽  
Saeid B. Amini ◽  
...  
Keyword(s):  
Claims Data ◽  
Medicare Claims ◽  
Case Ascertainment ◽  
Medicare Claims Data

scholarly journals Parkinson’s disease case ascertainment in a large prospective cohort

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251852
Author(s):  
Srishti Shrestha ◽  
Christine G. Parks ◽  
Marie Richards-Barber ◽  
Honglei Chen ◽  
Dale P. Sandler
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Medical Records ◽  
Epidemiologic Studies ◽  
Self Report ◽  
Health Study ◽  
Motor Symptoms ◽  
Case Ascertainment ◽  
Disease Case ◽  
Treatment Data

Background In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson’s disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study (AHS). Methods Doctor-diagnosed PD was self-reported on all cohort-wide surveys; potential cases were also identified from death certificates. Follow-up surveys asked about PD-related motor and non-motor symptoms. For PD confirmation, we collected additional diagnosis, symptom, and treatment data from 510 potential PD cases or their proxy (65% of those contacted) in a supplemental screener and obtained medical records for a subset (n = 65). We classified PD cases using established criteria and screener data. Results Of 510 potential PD cases, 75% were considered “probable” or “possible”; this proportion increased among participants diagnosed by a specialist (81.2%), taking PD medication (85.2%), or reporting ≥5 motor symptoms (86.8%) in a regular AHS survey. Of those with medical records, 93% (57 of 61) of probable or possible PD was confirmed. Never-smoking and non-motor and motor symptoms reported in prior AHS surveys were more common with probable/possible PD than unconfirmed PD. Conclusion In this retrospective PD case ascertainment effort, we found that PD self-report with information on motor symptoms or medications may be a reasonable alternative for identifying PD cases when physician exam is not feasible. Because of intervening mortality, screeners could not be obtained from about one-third of those contacted. Thus, findings warrant replication.

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