CONCURRENCE OF FRAILTY AND PARKINSON’S DISEASE

2012 ◽  
pp. 1-5
Author(s):  
K.P. ROLAND ◽  
K.M.D. CORNETT ◽  
O. THEOU ◽  
J.M. JAKOBI ◽  
G.R. JONES
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Levodopa Dose ◽  
Frailty Phenotype ◽  
Age Related

Background: Females with Parkinson’s disease (PD) are at greater risk of frailty than males. Little is known about how age and disease-related characteristics influence frailty in females with PD because frailty studies often exclude persons with underlying neurological pathologies. Objective: To determine age and diseaserelated characteristics that best explain physical frailty in community-dwelling females with and without PD. Design & Measurement: Correlation coefficients described relationships between PD-related characteristics and physical frailty phenotype criteria (Cardiovascular Health Study). Regression analysis identified associations between disease-related characteristics and frailty in non-PD and PD females. Setting: Community-dwelling. Participants: Females with mild to moderate PD (n = 17, mean age = 66 ± 8.5 years) and non-PD (n = 18, mean age = 72 ± 13.2 years) participated. Results: Daily carbidopa-levodopa dose best explained frailty in PD females (β = 0.5), whereas in non-PD females, age (β = 0.7) and comorbidity (β = 0.5) were most associated with frailty. Conclusions: Dopaminergic medication explained frailty in PD and not measures of disease progression (i.e. severity, duration). In females without PD age-related accumulation of comorbidities resulted in greater risk of frailty. This indicates dopaminergic management of PD symptoms may better reflect frailty in females with PD than disease severity or duration. These data suggest the influence of underlying frailty should be considered when managing neurological conditions. Understanding how frailty concurrently exists with PD and how these conditions progress within the aging female will facilitate future care management.

scholarly journals METABOLITES ASSOCIATED WITH HIGH VERSUS LOW WALKING ABILITY AMONG COMMUNITY-DWELLING OLDER MEN AND WOMEN

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S641-S642
Author(s):  
Megan M Marron ◽  
Stacy G Wendell ◽  
George C Tseng ◽  
Robert M Boudreau ◽  
Adam J Santanasto ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cardiovascular Health ◽  
Monounsaturated Fatty Acids ◽  
Community Dwelling ◽  
Dietary Lipids ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Walking Ability ◽  
Omega 3 ◽  
Age Related

Abstract Low walking ability is highly prevalent with advanced age and associated with a higher risk of major adverse health outcomes. Metabolomics may help better characterize differences among older adults with vastly different walking abilities and provide insight into altered metabolic processes underlying age-related declines in physical functioning. Here, we sought to identify metabolites associated with high versus low walking ability using a nested case-control study of 120 community-dwelling adults ages 79-95 (40% men, 10% black) from the Cardiovascular Health Study (CHS) All Stars study. Participants with high versus low walking ability were matched one-to-one on age, gender, race, and fasting time. Using liquid chromatography-mass spectrometry, 569 metabolites were identified in overnight-fasting plasma. High versus low walking ability was defined as the best versus worst tertile of gait speed (≥0.9 versus <0.7 meters/second) and Walking Ability Index scores (7-9 versus 0-1). Ninety-six metabolites were associated with walking ability extremes (p<0.05, false discovery rate<30%), where 24% were triacylglycerols. Triacylglycerols containing mostly polyunsaturated fatty acids (e.g., omega-3) were higher, whereas those containing mostly saturated/monounsaturated fatty acids were lower among those with high versus low walking ability. Arginine and proline metabolism was a top pathway identified. Body mass index partly explained the association between a subset of metabolites and walking ability extremes. These findings may partly reflect pathways implicating modifiable risk factors including excess dietary lipids and lack of physical activity, which contribute to obesity and cause further alterations in metabolic pathways, potentially leading to age-related declines in walking ability in this cohort.

scholarly journals Post Hoc Parkinson’s Disease: Identifying an Uncommon Disease in the Cardiovascular Health Study

2010 ◽  
Vol 35 (4) ◽  
pp. 241-249 ◽  
Author(s):  
T.G. Ton ◽  
S. Jain ◽  
R. Boudreau ◽  
E.L. Thacker ◽  
E.S. Strotmeyer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Uncommon Disease ◽  
Post Hoc

scholarly journals Discrepancy in Frailty Identification: Move Beyond Predictive Validity

2019 ◽  
Vol 75 (2) ◽  
pp. 387-393 ◽  
Author(s):  
Qian-Li Xue ◽  
Jing Tian ◽  
Jeremy D Walston ◽  
Paulo H M Chaves ◽  
Anne B Newman ◽  
...  
Keyword(s):  
Disease Burden ◽  
Prospective Observational Study ◽  
Cardiovascular Health ◽  
A Priori ◽  
Frailty Index ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Frailty Phenotype ◽  
Individual Level

Abstract Background To evaluate the discordance in frailty classification between the frailty index (FI) and the physical frailty phenotype (PFP) and identify factors discriminating those with discordant frailty classification from each other and from those for whom the assessments agree. Methods A prospective observational study of older adults aged 65 and older selected from Medicare eligibility lists in four U.S. communities (n = 5,362). The PFP was measured by the Cardiovascular Health Study PFP. Participants meeting three or more of the five criteria were deemed frail. The FI was calculated as the proportion of deficits in an a priori selected set of 48 measures, and participants were classified as frail if FI is greater than 0.35. Results The prevalence of frailty was 7.0% by the PFP and 8.3% by the FI. Of the 730 deemed frail by either instrument, only 12% were in agreement, whereas 39% were classified as frail by the PFP, but not the FI, and 48% were classified as frail by the FI, but not the PFP. Participants aged 65–72 years or with greater disease burden were most likely to be characterized as being FI-frail, but not PFP-frail. The associations of frailty with age and mortality were stronger when frailty was measured by the PFP rather than the FI. Conclusions Despite comparable frailty prevalence between the PFP and the FI, there was substantial discordance in individual-level classification, with highest agreement existing only in the most vulnerable subset. These findings suggest that there are clinically important contexts in which the PFP and the FI cannot be used interchangeably.

scholarly journals Markers of inflammation in prevalent and incident Parkinson’s disease in the Cardiovascular Health Study

2012 ◽  
Vol 18 (3) ◽  
pp. 274-278 ◽  
Author(s):  
Thanh G.N. Ton ◽  
Samay Jain ◽  
Mary L. Biggs ◽  
Evan L. Thacker ◽  
Elsa S. Strotmeyer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Markers Of Inflammation

Influence of Physical Activity on Age-Related Weight Loss in the Elderly

2010 ◽  
Vol 7 (1) ◽  
pp. 78-86 ◽  
Author(s):  
Wendy C. Stephen ◽  
Ian Janssen
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Body Weight ◽  
Cardiovascular Health ◽  
Disease Status ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Age Related

Background:Little is known about the effects of physical activity on weight loss in older adults.Methods:Participants included 4512 community-dwelling older (≥65 yr) men and women from the Cardiovascular Health Study. Physical activity (PA) was determined from a questionnaire at baseline and subjects were divided into sex-specific PA quartiles. Weight was measured at baseline and annually over the 8 years of follow-up. The influence of PA on longitudinal changes in body weight was examined using mixed models while adjusting for lifestyle variables, sociodemographic characteristics, and disease status.Results:Body weight declined in a curvilinear manner over time with accelerated weight loss occurring in the final years. Over the 8 yr follow-up period, the least active PA quartile lost 2.72 kg. Weight loss was attenuated by 0.55 kg (20%, P = .057), 0.80 kg (29%, P = .05), and 0.69 kg (25%, P = .016) within the second through fourth PA quartiles. The effects of PA did not differ by gender, but increased with advancing age.Conclusion:Participation in modest amounts of PA attenuated age-related weight loss by approximately 25% with little additional benefit observed at higher PA levels. This finding adds to the growing number of health outcomes that are positively affected by PA.

scholarly journals Higher frailty burden in older adults with chronic constipation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jihye Lim ◽  
Hyungchul Park ◽  
Heayon Lee ◽  
Eunju Lee ◽  
Danbi Lee ◽  
...  
Keyword(s):  
Older Adults ◽  
Chronic Constipation ◽  
Cardiovascular Health ◽  
Functional Constipation ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Geriatric Syndrome ◽  
Frailty Phenotype ◽  
Cross Sectional

Abstract Background Despite constipation being a common clinical condition in older adults, the clinical relevance of constipation related to frailty is less studied. Hence, we aimed to investigate the association between chronic constipation (CC) and frailty in older adults. Methods This is a cross-sectional analysis of a population-based, prospective cohort study of 1278 community-dwelling older adults in South Korea. We used the Rome criteria to identify patients with irritable bowel syndrome with predominant constipation (IBS-C) and functional constipation (FC). We investigated whether participants consistent with the criteria for IBS-C and FC had CC. Frailty was assessed using the Cardiovascular Health Study (CHS) frailty phenotype. Results In the study population with a mean age of 75.3 ± 6.3 years, 136 (10.7%) had CC. The participants with CC were older, had higher medication burdens, and had worse physical performances compared to those without CC (All P < .05). By association analysis, the prevalence of CC was associated with frailty by the CHS criteria (P < .001). The CHS frailty score was associated with the presence of CC by the univariate logistic regression analysis and the multivariate analysis adjusted for age, sex, and multimorbidity. Conclusions Frailty was associated with CC in community-dwelling older people, suggesting that constipation should be considered as an important geriatric syndrome in clinical practice concerning frail older adults.

scholarly journals Association between Physical Frailty Subdomains and Oral Frailty in Community-Dwelling Older Adults

2021 ◽  
Vol 18 (6) ◽  
pp. 2931
Author(s):  
Ryo Komatsu ◽  
Koutatsu Nagai ◽  
Yoko Hasegawa ◽  
Kazuki Okuda ◽  
Yuto Okinaka ◽  
...  
Keyword(s):  
Older Adults ◽  
Gait Speed ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Physical Frailty ◽  
Cross Sectional ◽  
Important Indicator ◽  
Community Dwelling Older Adults ◽  
Oral Frailty

This cross-sectional study aimed to demonstrate the association between physical frailty subdomains and oral frailty. This study involved community-dwelling older adults (aged ≥65 years). Physical frailty was assessed with the Japanese version of the Cardiovascular Health Study criteria. Oral frailty was defined as limitations in at least three of six domains. Logistic regression analysis was used to analyze the association between physical frailty risk and oral frailty. In addition, we examined the association between physical frailty subdomains (gait speed, grip strength, exhaustion, low physical activity, and weight loss) and oral frailty. A total of 380 participants were recruited for this study. Overall, 18% and 14% of the participants were at risk of physical frailty and had oral frailty, respectively. Physical frailty risk (odds ratio (OR) = 2.40, 95% confidence interval (CI): 1.22–4.75, p = 0.012) was associated with oral frailty in multivariate analysis. In secondary analysis, among physical frailty subdomains, gait speed (OR = 0.85, 95% CI: 0.73–0.97, p = 0.019) was associated with oral frailty. The present findings suggest that physical frailty is closely related to oral frailty. Among physical frailty subdomains, decreased gait speed in particular is an important indicator related to the development of oral frailty.

scholarly journals Left atrial diameter and vascular brain injury on MRI

Neurology ◽  
2018 ◽  
Vol 91 (13) ◽  
pp. e1237-e1244 ◽  
Author(s):  
Shadi Yaghi ◽  
Traci M. Bartz ◽  
Richard Kronmal ◽  
Hooman Kamel ◽  
John Gottdiener ◽  
...  
Keyword(s):  
Brain Injury ◽  
Left Atrial ◽  
Cardiovascular Health ◽  
Brain Mri ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Linear Regression Models ◽  
Left Atrial Diameter ◽  
Brain Infarcts

ObjectiveTo determine the association left atrial diameter (LAD) and vascular brain injury on brain MRI.MethodsWe analyzed data from the Cardiovascular Health Study (CHS), a prospective cohort of community-dwelling adults ≥65 years old. LAD was measured from 2-dimensional transthoracic echocardiograms. Among CHS participants who underwent brain MRI, we examined associations of LAD with brain infarcts and leukoaraiosis. Primary outcomes (number for analysis) were prevalent infarcts (2,327) and degree of leukoaraiosis on initial MRI (2,315). Secondary outcomes were prevalent nonlacunar infarcts (2,327), incident infarcts (939), incident nonlacunar infarcts (1,185), and degree of leukoaraiosis on follow-up MRI adjusted for initial MRI (1,158). Relative risk (RR) and linear regression models were adjusted for demographics, vascular risk factors, and potential confounders.ResultsMean age of the 2,335 participants with initial brain MRI was 72.0 ± 4.8 years; 38.7% were men; and 29.0% participants had prevalent infarcts. In multivariable, fully adjusted models, LAD was associated with prevalent infarcts (RR 1.20, 95% confidence interval [CI] 1.08–1.34) and prevalent nonlacunar infarcts (RR 1.28, 95% CI 1.06–1.54) but not with leukoaraiosis (−0.08, 95% CI −0.17 to 0.07), incident infarcts (RR 1.00, 95% CI 0.78–1.29), nonlacunar infarcts (RR 0.98, 95% CI 0.67–1.42), or worsening leukoaraiosis (−0.04, 95% CI −0.10 to 0.02).ConclusionLAD is independently associated with prevalent brain infarcts, particularly nonlacunar infarcts, but not leukoaraiosis. Larger studies are needed to determine associations with incident infarct risk and whether this risk in patients with left atrial enlargement can be reduced with anticoagulant agents.

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