Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester

10.1002/pd.98 ◽  
2001 ◽  
Vol 21 (6) ◽  
pp. 441-444 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W. Liao ◽  
Charas Y. T. Ong ◽  
Lut Geerts ◽  
Kypros H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Serum Levels ◽  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A

Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies

10.1002/pd.53 ◽  
2001 ◽  
Vol 21 (4) ◽  
pp. 270-273 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W Liao ◽  
Hariklea Skentou ◽  
Charas YT Ong ◽  
Kypros H Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Serum Levels ◽  
First Trimester ◽  
Activin A ◽  
Maternal Serum

First-Trimester Contingent Screening for Trisomy 21 by Fetal Nuchal Translucency and Maternal Serum Biomarkers and Maternal Blood Cell-Free DNA Testing

2018 ◽  
Vol 5 (3) ◽  
pp. 139-143
Author(s):  
Sarang Younesi ◽  
Shahram Savad ◽  
Soudeh Ghafouri-Fard ◽  
Mohammad Mahdi Taheri-Amin ◽  
Pourandokht Saadati ◽  
...  
Keyword(s):  
Blood Cell ◽  
Trisomy 21 ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Serum Biomarkers ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

Vitamine D en het risico op ASS

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Huub F.J. Savelkoul
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
First Trimester ◽  
Autism Spectrum ◽  
Maternal Serum ◽  
Immune Reactivity ◽  
Anti Oxidant ◽  
First Trimester Of Pregnancy ◽  
Spectrum Disorders

Autism spectrum disorders (ASD) is a heterogeneous group of behavioral disorders in which a disturbed immune reactivity can contribute to the etiology. In retrospective research we found an association between the risk to develop ASD and the month of birth with a peak in July pointing at a possible decreased exposure to sunlight during the first two semesters of pregnancy. This could point to an important role of vitamin D which has important anti-inflammatory and anti-oxidant activities and thereby regulates the proper functioning of the immune system in these individuals. Maternal serum levels of vitamin D double during the first trimester of pregnancy and therefore decreased exposure to sunlight resulting in diminished levels of vitamin D production can be an important risk factor for the development of ASD. However, there is a need for more integrated multidisciplinary studies in families where all siblings are also studied to elucidate the contribution of their genetic risk factors.

scholarly journals M20. CYTOKINE LEVELS THROUGHOUT PREGNANCY AND RISK FOR PSYCHOSIS IN ADULT OFFSPRING: EARLY PREGNANCY MATTERS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S141-S141
Author(s):  
Dana Allswede ◽  
Robert Yolken ◽  
Stephen Buka ◽  
Tyrone Cannon
Keyword(s):  
Psychotic Disorder ◽  
Early Pregnancy ◽  
Serum Levels ◽  
First Trimester ◽  
Underlying Mechanism ◽  
Maternal Serum ◽  
Serum Samples ◽  
Birth Complications ◽  
Cytokine Levels ◽  
Pregnancy And Birth

Abstract Background Schizophrenia has been associated with pregnancy and birth complications, and fetal exposure to inflammation is thought to be a common underlying mechanism. However, it is unclear whether the risk associated with inflammation is specific to particular phases of pregnancy, as no prior studies have examined maternal serum samples across multiple assessments from the first trimester onward. This study examined differences in longitudinal patterns of maternal serum levels of TNFa, IL-1b, IL-5, IL-6, IL-8, IL-10, and IL-17a across pregnancy for offspring who were later ascertained as having a psychotic disorder diagnosis, non-psychotic siblings of these cases, and unrelated, non-psychotic individuals who served as controls. Methods Participants included 90 offspring, 79 siblings, and 273 matched controls from the Philadelphia cohort of the National Collaborative Perinatal Project. Psychotic disorder diagnoses in adulthood were assessed with review of medical records and were confirmed with a validation study. Cytokine levels were assessed using a multiplex bead assay in archived maternal serum samples collected across prenatal visits and birth. Results Levels of pro-inflammatory TNFa, IL-1b, and IL-6 were significantly higher in maternal serum of offspring who later developed psychosis relative to maternal serum of non-psychotic siblings and matched controls. These differences were maximal in first half of pregnancy (7–20 weeks), tapering to non-significant during the second half of pregnancy. Discussion These findings elucidate the importance of exposure to elevated maternal pro-inflammatory cytokine levels in early pregnancy to the etiology of psychosis.

Maternal serum ADAM12s in the late first trimester of pregnancies with Trisomy 21

2008 ◽  
Vol 28 (5) ◽  
pp. 422-424 ◽  
Author(s):  
Kevin Spencer ◽  
Nicholas J. Cowans ◽  
Anastasia Stamatopoulou
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Serum

Maternal serum inhibin-A and free beta-hCG concentrations in trisomy 21 pregnancies at 10 to 14 weeks of gestation

1997 ◽  
Vol 104 (3) ◽  
pp. 367-371 ◽  
Author(s):  
P. L. Noble ◽  
E. M. Wallace ◽  
R. J. M. Snijders ◽  
N. P. Groome ◽  
K. H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Maternal Serum ◽  
Inhibin A ◽  
Beta Hcg

First trimester maternal serum inhibin A concentrations in smokers

2013 ◽  
Vol 33 (3) ◽  
pp. 296-297 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Kevin Spencer
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A
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