First trimester maternal serum inhibin A concentrations in smokers

2013 ◽  
Vol 33 (3) ◽  
pp. 296-297 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Kevin Spencer
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A

scholarly journals Potential screening strategies for early prediction of pre-eclampsia

2021 ◽  
Vol 10 (4) ◽  
pp. 1436
Author(s):  
Hymavathi K. ◽  
Sandhya Rani Davuluru ◽  
Sameera Shaik ◽  
Sahithi Kaviti
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Uterine Artery ◽  
Strong Association ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tools ◽  
Early Prediction ◽  
Inhibin A ◽  
Study Results

Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester

10.1002/pd.98 ◽  
2001 ◽  
Vol 21 (6) ◽  
pp. 441-444 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W. Liao ◽  
Charas Y. T. Ong ◽  
Lut Geerts ◽  
Kypros H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Serum Levels ◽  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A

scholarly journals Inhibin A and Activin A in the First Trimester of Human Pregnancy

1997 ◽  
Vol 82 (5) ◽  
pp. 1557-1560 ◽  
Author(s):  
Mary Birdsall ◽  
William Ledger ◽  
Nigel Groome ◽  
Hossam Abdalla ◽  
Shanthi Muttukrishna
Keyword(s):  
First Trimester ◽  
Activin A ◽  
Maternal Serum ◽  
Corpora Lutea ◽  
Specific Enzyme ◽  
Inhibin A ◽  
Human Pregnancy ◽  
First Trimester Of Pregnancy ◽  
Donor Egg ◽  
High Concentrations

Abstract Recent studies show that high concentrations of inhibin A and activin A are present in the maternal serum throughout human pregnancy. The aim of this study was to determine whether the corpus luteum produces significant quantities of inhibin A and activin A during the first trimester of pregnancy. This prospective study examined two groups of women who had blood samples taken from 5–12 weeks gestation. One group consisted of 14 women with donor egg pregnancies (8 singletons and 6 multiples) who did not have corpora lutea, and the other group consisted 5 women with spontaneous pregnancies who had corpora lutea. Inhibin A and activin A were measured at weekly intervals using specific enzyme immunoassays. All pregnancies progressed to term, with healthy babies being delivered. Maternal serum concentrations of inhibin A significantly increased throughout the study period in the donor egg pregnancies (P &lt; 0.001) and the control pregnancies (P &lt; 0.001). Circulating concentrations of activin A also increased significantly in both the spontaneous and donor egg pregnancies (P &lt; 0.001) during the study period. However, the concentrations of inhibin A and activin A in the first trimester of human pregnancy were not significantly different in the women with or without corpora lutea, suggesting a fetoplacental origin. Multiple donor egg pregnancies were found to have higher concentrations of inhibin A (P &lt; 0.001) and activin A (P &lt; 0.05) compared with singleton donor egg pregnancies, which also supports a placental source.

Predicting complications of pregnancy with first-trimester maternal serum free-?hCG, PAPP-A and inhibin-A

2003 ◽  
Vol 23 (12) ◽  
pp. 990-996 ◽  
Author(s):  
Nata?a Tul ◽  
Stanko Pu?enjak ◽  
Jo?ko Osredkar ◽  
Kevin Spencer ◽  
?iva Novak-Antoli?
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A ◽  
Serum Free

Evaluation of maternal serum dimeric inhibin a as a first-trimester marker of down's syndrome

1995 ◽  
Vol 15 (4) ◽  
pp. 359-362 ◽  
Author(s):  
E. M. Wallace ◽  
V. E. Grant ◽  
I. A. Swanston ◽  
N. P. Groome
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A

The distance between the embryo and yolk sac associated with inhibin A in the first-trimester pregnancy – which is the novelty?

2019 ◽  
Vol 1 (67) ◽  
pp. 13
Author(s):  
Carmen Elena Bucuri ◽  
Răzvan  Ciortea ◽  
Andrei Mihai Malutan ◽  
Cristian Iuhaș ◽  
Maria Rada ◽  
...  
Keyword(s):  
First Trimester ◽  
Yolk Sac ◽  
Inhibin A ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy
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