Predicting complications of pregnancy with first-trimester maternal serum free-?hCG, PAPP-A and inhibin-A

2003 ◽  
Vol 23 (12) ◽  
pp. 990-996 ◽  
Author(s):  
Nata?a Tul ◽  
Stanko Pu?enjak ◽  
Jo?ko Osredkar ◽  
Kevin Spencer ◽  
?iva Novak-Antoli?
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A ◽  
Serum Free

Stability of maternal serum free β-hCG following whole blood sample transit: First trimester Down’s syndrome screening in Scotland

2021 ◽  
pp. 000456322110452
Author(s):  
Angela Ballantyne ◽  
Lorna Rashid ◽  
Rebecca Pattenden
Keyword(s):  
Transit Time ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
First Trimester ◽  
Maternal Serum ◽  
Dependent Manner ◽  
Serum Free ◽  
Β Hcg ◽  
In Transit ◽  
The Impact

Background Maternal serum free beta human chorionic gonadotrophin (free β-hCG) is used as a biomarker in first trimester screening for fetal Down’s syndrome. Production of free β-hCG can occur in vitro in a time- and temperature-dependent manner; thus, the current Scottish screening protocol states samples must be received by the laboratory within 72 h. To assess the validity of the protocol, an audit was conducted to determine the impact of transit time on maternal serum free β-hCG multiple of median (MoM) values in the Scottish screened population. Methods Corrected MoM values from antenatal screening carried out over one year (April 2017 to March 2018) were stratified according to sample transit time and compared. To investigate possible environmental temperature effects, the data were split according to season and maternal serum free β-hCG concentrations from summer and winter compared. Results Of the 28,368 samples included in the study, 24,368 were received on the day of phlebotomy or after one day in transit. Only 1.5% of samples were received after 3 days in transit. The difference in maternal serum free β-hCG MoM values due to transit time was not significant. No statistical difference was found between maternal serum free β-hCG concentrations from samples collected in summer and winter months. Conclusion The current sample receipt protocol in use by the Scottish Down’s syndrome screening programme is fit for purpose.

scholarly journals P03.20: Association between first trimester maternal serum free hCG and PAPP-A and preterm delivery

2004 ◽  
Vol 24 (3) ◽  
pp. 287-287
Author(s):  
A. Ricciardulli ◽  
A. Di Iorio ◽  
M. Liberati ◽  
G. Ricciardulli ◽  
U. Bellati
Keyword(s):  
Preterm Delivery ◽  
First Trimester ◽  
Maternal Serum ◽  
Serum Free

First trimester maternal serum inhibin A concentrations in smokers

2013 ◽  
Vol 33 (3) ◽  
pp. 296-297 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Kevin Spencer
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A

scholarly journals Potential screening strategies for early prediction of pre-eclampsia

2021 ◽  
Vol 10 (4) ◽  
pp. 1436
Author(s):  
Hymavathi K. ◽  
Sandhya Rani Davuluru ◽  
Sameera Shaik ◽  
Sahithi Kaviti
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Uterine Artery ◽  
Strong Association ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tools ◽  
Early Prediction ◽  
Inhibin A ◽  
Study Results

Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester

10.1002/pd.98 ◽  
2001 ◽  
Vol 21 (6) ◽  
pp. 441-444 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W. Liao ◽  
Charas Y. T. Ong ◽  
Lut Geerts ◽  
Kypros H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
Serum Levels ◽  
First Trimester ◽  
Maternal Serum ◽  
Inhibin A
Sign in / Sign up

Export Citation Format

Share Document